Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"HFpEF"”.
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PRESERVE HFpEF: Designing a blended lifestyle intervention to improve physical function, dietary intake, and quality of life in multi-morbid older people who have Heart Failure with preserved Ejection Fraction (HFpEF)
… Heart Failure with preserved Ejection Fraction (HFpEF), a type of heart failure, has been described as a ‘stealth syndrome’ and ‘the greatest unmet need in cardiology.’ These labels have arisen because of the increasing number of people receiving a diagnosis and the growing body of evidence …
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Investigation and analysis of heart failure with preserved ejection fraction (HFpEF) with Magnetic resonance
Heart Failure with preserved Ejection fraction (HFpEF) is a cardiovascular condition which is steadily on the rise. It is a major affliction in the elderly with higher incident rates in females and the obese. Exercise intolerance even to submaximal exercise is the cardinal symptom of this disease. …
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Comparing Healthcare Resource Utilization and Costs in HFPEF patients using SGLT2-inhibitor Combination Treatments: A Retrospective Claims Analysis
… Heart failure with preserved ejection fraction (HFpEF) represents an increasingly significant clinical burden. Recent treatment guidelines recommend sodium-glucose cotransporter-2 inhibitors (SGLT2i) as foundational therapy, with the addition of either mineralocorticoid receptor antagonists …
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The pathophysiology of heart failure with preserved ejection fraction
Our studies demonstrate that patients with HfpEF have impaired myocardial energetics as indicated by the diminished in vivo myocardial PCr/ATP ratio. Data acquired during semi-supine cycling exercise indicates that patients with HfpEF had a dynamic impairment of LV active relaxation. In addition, …
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Exploring the role of Wnt signalling in heart failure with preserved ejection fraction.
… heart failure with preserved ejection fraction (HFpEF) accounts for approximately 16% of heart failure cases, with survival rates failing to improve due to the lack of effective treatments and the increasing prevalence of co-morbidities. It has been widely documented throughout the literature …
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Chronotropic Incompetence in Patients with Heart Failure and a Preserved Ejection Fraction: Prevalence and Impact on Exercise Tolerance
… only one small study has examined this in HFpEF subjects. Furthermore, there are no published studies that have evaluated the effects of a pharmacologic or exercise intervention on the prevalence of CI in the HFpEF population. OBJECTIVE: The primary objective of this study was to determine …
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Ávísun lyfjameðferða eftir mismunandi svipgerðum hjartabilunar við útskrift á hjartadeild Landspítala: Eru íslenskir hjartabilunarsjúklingar að fá meðferð í samræmi við klínískar leiðbeiningar Evrópsku hjartalæknasamtakanna?
… skert (HFrEF), vægt skert (HFmrEF) og varðveitt (HFpEF). Klínískar leiðbeiningar ráðleggja HFrEF sjúklingum beta blokkara (BB), saltstera/aldósterón viðtakablokkara (MRA), samflutningspróteins natríumglúkósa-2 hemla (SGLT2i), auk annars af eftirfarandi angíótensín breytihvatahemlum (ACEI): …
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Modulation of Cardiac Titin Stiffness in Physiological and Pathophysiological States
… Heart Failure with Preserved Ejection Fraction (HFpEF) which is marked by increased diastolic stiffness. Here, I investigated the effects of titin phosphorylation by two kinases, ERK2 and CaMKIIδ, at the level of the protein and the myocardium. Additionally, I used mouse models of HFpEF to test …
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Investigating the impact of non-alcoholic fatty liver disease on the pathogenesis and progression of heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction (HFpEF) is a growing public health concern due to its increasing incidence alongside a lack of effective therapeutics. Understanding how this condition develops is therefore of the utmost importance in order to develop preventative strategies. As such, …
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The prevalence, profile, and prognosis of heart failure with preserved ejection fraction: A South African tertiary hospital experience
… heart failure with preserved ejection fraction (HFpEF) in Sub-Saharan Africa. We therefore aimed to describe the prevalence, profile and outcomes of HFpEF patients admitted to a South African tertiary hospital. Methods. We retrospectively reviewed all consecutive de novo heart failure admissions …
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The Role of Metabolic Inflexibility in Heart Failure
… a type of HF with preserved ejection fraction (HFpEF) ensues. HFpEF is distinct from HF with reduced ejection fraction (HFrEF) and diabetes in clinical presentation and physiology, necessitating alternative treatments. Understanding metabolic alterations which contribute to the development and …
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Soft Robotic Platforms for the Simulation of Cardiovascular Disease and Device Development
… heart failure with preserved ejection fraction (HFpEF), affecting over 40 million people worldwide. This work first describes the development of a tunable and biomimetic soft robotic aortic sleeve that can re-create the anatomy and hemodynamics of AS with high fidelity. In a preclinical swine …
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OBJECTIVELY MEASURED PHYSICAL ACTIVITY LEVELS AND THEIR RELATIONSHIP TO PHYSICAL FITNESS/FUNCTION IN HEART FAILURE PATIENTS
… heart failure and a preserved ejection fraction (HFpEF), examine the relationship of PA levels to other physical fitness/functional measures, and determine if there are significant differences between objectively measured PA levels and well-established prognostic measures in this population.
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THE ROLE OF EXTRACELLULAR VESICLES IN HEART DISEASES
… (HFrEF) and preserved ejection fractions (HFpEF), focusing on their potential utility in phenotypic refinement, and comparison with healthy controls. By analyzing these two pathologically distinct cardiac conditions, this project also seeks to determine whether differences in EV …
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FUNCTIONAL, STRUCTURAL, CELLULAR, AND MOLECULAR CARDIAC RESPONSES IN NONHUMAN PRIMATE MODELS OF MENOPAUSE AND RADIATION EXPOSURE
… heart failure with preserved ejection fraction (HFpEF). Myocardial fibrosis appears to be a shared pathologic feature of both conditions, but the underlying mechanism(s) and end stage results on cardiac function are currently unclear.
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Artificial neural network models utilize chamber-specific predictors of cardiac fibrosis in ovariectomized and aortic-banded Yucatan mini-swine
… Heart failure with preserved ejection fraction (HFpEF) is a disease associated with significant clinical pathophysiological heterogeneity in which maladaptive cardiac fibrosis, in both the right and left ventricles of the heart, plays a unique role in the manifestation of disease. Fibrotic …
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Sex dimorphism in the cardiometabolic effects of the smoothelin-like 1 protein deletion in an ageing mouse model
… heart failure with preserved ejection fraction (HFpEF) condition and represents a novel preclinical model with comorbidities to study the etiology of the HFpEF clinical phenotype.
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A Pilot Study: Observations of Patients Participating in Heart Failure Shared Medical Appointments while Receiveing Nutrition Education
… of HF with preserved ejection fraction (HFpEF). Average weights of the participants ranged from 171.4 lbs to 339.6lbs. Quality of life (QOL) for this group of patients was diverse, average MLHF scores ranging from 0.4-78.3. The 3 lowest scores on the MLHF questionnaire and the 3 lowest …
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Improving Mass Spectrometry-Based Metabolite Identification and Quantification and Application to Cardiovascular Disease
… heart failure with preserved ejection fraction (HFpEF) as a model to demonstrate the power of targeted metabolomic profiling in testing existing hypotheses of CVD biomarkers and mechanisms. In a second study, we used incident CVD events as a model to 1) apply the refined methods from the first …
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Identifying Observational and Causal Factors for Cardiovascular Diseases through Large-scale Cohorts
… subtypes of heart failure, defined by preserved (HFpEF) or reduced (HFrEF) ejection fraction, Conclusions The emergence of large-scale data sources, with and without genetics, has allowed for analyses that require immense power, leading to novel insights into cardiovascular diseases.
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