Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"HFE"”.
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Studies at the hemochromatosis (HFE) locus : gene conversions, haplotypes, and association analysis
… gene responsible for hereditary hemochromatosis (HFE) to investigate the impact of meiotic recombination events upon haplotype structure in this region. First we identified crossover hotspots in order to define the boundaries of haplotype blocks in this locus. We then found that gene conversion …
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Characterization of the degradation of wild-type and mutant HFE proteins during stress signalling in the endoplasmic reticulum
HFE is a transmembrane protein that becomes N-glycosylated during transport to the cell membrane. It acts to regulate cellular iron uptake by interacting with the Type 1 transferrin receptor and interfering with its ability to bind iron-loaded transferrin. There is also evidence that HFE regulates …
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Untersuchungen zur immunologische Rolle von HFE, einem HLA Klasse I homologen Gen, das bei der hereditären Hämochromatose Punktmutationen zeigt
… Hämochromatose vom Typ 1 ursächliche Gen, <br>HFE, liegt telomerisch vom HLA-A-Lokus auf dem menschlichen Chromosom 6. Während <br>die Assoziation des HFE-Proteins mit dem Transferrinrezeptor die Grundlage für seine Rolle <br>im Eisenstoffwechsel bildet, konnte trotz seiner Homologie zu den …
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Genetic and environmental modifiers of iron overload disease. Why do only some patients get serious health outcomes?
… is most commonly caused by homozygosity for the HFE C282Y variant and to a far lesser extent other HFE C282Y and H63D genotypes. Haemochromatosis is one of the most common genetic conditions in populations of Northern European ancestry, with approximately 1 in 150 individuals carrying the …
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The effects of horizontal fiscal equalization on the expenditures of local governments: the case of Seoul, Korea
… possible with Horizontal Fiscal Equalization (HFE), a transfer between units at the same level of government, but there is little empirical evidence to validate this. In particular, there is scarcer research on how the expenditure decisions of local governments respond to HFE implementation. …
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Modular Human-in-the-loop Design Framework Based on Human Factors
… (DHM) to incorporate Human Factors Engineering (HFE) design principles early in design process. It embodies scientific methods (e.g., mathematics) and artistic approaches (e.g., visualization) to assess human well-being and overall system performance. This framework focuses not only on ergonomics …
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Systems Theoretic Process Analysis of Sociotechnical Systems
… expertise in human factors engineering (HFE), they may be unable to thoroughly and rigorously identify critical unsafe interactions. This thesis presents a process for utilizing HFE to improve the results of STPA analyses on sociotechnical systems. In particular, the process focuses on …
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Heterozygote Hämochromatose-Genmutationen als genetische Progressionsfaktoren bei chronischer Hepatitis C
… our aim was to assess associations between HFE mutations and hepatic inflammation and stage of fibrosis in German hepatitis C patients. Methods: Liver biopsies from 166 patients were scored for inflammatory activity (A0 - 4) and hepatic fibrosis (F0 - 4). Gene mutations were determined by …
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Molecular responses of iron regulatory proteins to iron overload in human liver
… despite knowledge of the causative mutations in HFE. In an attempt to gain an insight into the complexity of HH, transcript and protein levels of key iron-related molecules were investigated in liver specimens from patients with HFE-related HH. Protein levels of iron regulatory protein 1 (IRP1), …
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Development of nano composite coatings for enhanced performance in non-conventional lubricants under sliding contact.
… various operating conditions. Hydrofluoroethers (HFEs) are within the family of newly developed environmentally friendly refrigerants with a wide range of application areas. HFE-7000 is a replacement solution for the existing harmful refrigerants and thermo-fluids having a broad range of …
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A multi-functional electrolyte for lithium-ion batteries
… positive electrode of the cell. The inert fluid HFE-7000 is investigated as the volatile co-solvent in the MFE (1 M LiTFSI in 1:1 HFE-7000/ethyl methyl carbonate by volume) for the proposed TMS. In the first phase of the study, the baseline electrochemical performance of the MFE is determined by …
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Using object process methodology to develop interfaces and smart electronic procedures for simulated telerobotic operations
… traditionally used in human factors engineering (HFE)? A NASA sponsored EP development project provided the opportunity to investigate. HFE traditionally supports analysis and design by using multiple Task Analysis (TA) methods, including Hierarchical TA (HTA), Tabular TA (TTA), and Abstraction …
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Metabolic Syndrome In Obese African American Adolescents
… nutrition knowledge, home food environment (HFE), and serum calcium, leptin, 1,25-dihydroxy vitamin D (1, 25 D3) levels. One hundred and fifty one OAAA (mean age: 14.3 ± 1.4 years, 65.6% girls, mean BMI: 37.4±7.2 kg/m2) in a metropolitan area took part in this study. Anthropometric data and …
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Geochemistry of the Sabie River Basalt Formation in the central Lebombo, Karoo Igneous Province
… (LFE) group and a high-Fe "enriched" group (HFE). The LFE-group basalts, which predominate at the base of the stratigraphic sections, are considered to be equivalent to basalts occurring in the N. Lebombo. In the central Lebombo N-group basalts predominate in the mid- and upper portions of …
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Incorporation of cyanide ligands into models of [FeFe]- and [NiFe]-hydrogenase
… boranes to the Fe-CN of the [NiFe]-H2ase model [HFe(CO)3(CN)2]‒ was explored in Chapter 3. The compound [HFe(CO)3(CN)2]‒ is a possible synthon for a one-pot synthesis of [NiFe]-H2ase models as the Fe center is coordinated by carbonyl, cyanide, and a hydride ligands. Reactions of [HFe(CO)3(CN)2]‒ …
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Molecular and cellular insights into iron regulation
… of the previously unknown CHO-gene sequences of Hfe, Slc40-a1 and Irp2, was achieved. To determine the effect of intracellular iron overload on hepcidin expression, recombinant transferrin receptor 1 (rec-TfR1) HepG2 cells were created which express modified TfR1 to maximise iron uptake. Upon …
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Characterization of Emulsion Aggregate Mixtures
… and open-graded aggregates treated with HFE-300 and CSS-1 emulsions are evaluated. Shear strength, repeated loading response (resilient modulus, permanent deformation), tensile strength, Dynamic Cone Penetrometer (DCP) and curing effects are evaluated in the laboratory. In-service EAM …
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Development and characterization of next generation batteries
… and the effect of adding hydrofluoroether (HFE) cosolvent on the cycling performance of Li−S battery is discussed. In order to evaluate interactions that might change Li−S battery properties, four different HFEs with varying degrees of fluorination were examined as cosolvents in the …
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Surface structure enhanced microchannel flow boiling of low surface tension fluids
… for electronics cooling, and hydrofluoroether (HFE) 7000, an environmentally friendly dielectric fluid. Though there are benefits to using these alternative working fluids, several of their thermophysical properties involved in generating capillary flows are significantly less than that of …
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