Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 124 for “"HFD"”.
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The impact of NOX4 deficiency on sexually dimorphic lipid handling in HFD-challenged mice
Dietary excess promotes metabolic dysfunction through nutrient overload. If sustained, it can impair physiological metabolic processes necessary for the proper handling of nutrients. Proper handling of nutrients depends on the capacity of an organism to properly sense, regulate, respond, and adapt …
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Linking Inflammation to Tumorigenesis In A Mouse Model of High-Fat Diet-Enhanced Colon Cancer: Does Fat Type Matter?
… suggest an association between high-fat diet (HFD) and colon cancer risk. However, the lack of controlled experimental studies that examine this relationship and the mechanisms involved weaken the basis for inferring a causal relationship. Inflammation plays a role in colon cancer progression …
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The Effect of Early Dietary Intervention on Alzheimer's Disease-Related Pathology and Cognitive Function in Mice
… AD, it might be predicted that a high fat diet (HFD) would worsen AD pathology. However, modeling HFD-induced obesity in animal models of AD has yielded inconclusive results. Some studies report a deleterious effect of HFD on Aβ accumulation, neuroinflammation, and cognitive function, while …
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Effects of diet on behavioural domains relevant to schizophrenia- a preclinical perspective
… thesis, I examined the effect of high fat diet (HFD) in two mutant mouse models for the genetic risk factor neuregulin 1 (NRG1), the transmembrane domain Nrg1 (Nrg1 TM HET) and the Nrg1 type III (Nrg1 III tg) models, and how HFD in a maternal obesity model in C57BL/6J mice can modify …
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Investigation of the metabolic phenotype and metformin response of <i>ATM</i> heterozygous mice
… in C57BL/6J (WT) male mice fed high fat diet (HFD) and B6.129S6-ATMtm1Awb/J heterozygous (ATM+/-) male mice fed HFD through the use of metabolic phenotyping techniques such as body composition analysis, glucose tolerance test, insulin tolerance test and calorimetric monitoring. This study …
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Modulation of bio-behaviors and diabesity by dietary factors
… mice were fed a 60% fat diet (high fat diet; HFD) or a 10% fat (low fat diet; LFD) for 1 or 3 weeks post-weaning, after which mice were subjected to behavioral testing. HFD-fed mice had increased anxietal-like and reward seeking behavior and decreased performance in spatial and non-spatial …
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Immunological and behavioral consequences of high-fat diet feeding in mice
… we show that obese mice fed a high-fat diet (HFD), fail to exhibit an interest in saccharin (27% vs 74%) compared to mice fed a low-fat diet (LFD) (p < 0.007). When HFD mice undergo a fasting period of 24 hours, saccharin preferences equilibrate to water consumption (51% saccharin vs 49% …
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Protective effects of regular exercise and Korea red ginseng against high-fat diet-increased renal injury in ᴅ-galactose-induced aging rats
… process. Obesity induced by a high-fat diet (HFD) may reduce renal function. However, the impact of obese on the age-related renal disease is not well understood. Exercise reduces oxidative stress. Korean red ginseng (KRG) has been reported to ameliorate oxidative tissue injury and has an …
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High Saturated Fat Diet Induces Gestational Diabetes, Perinatal Skeletal Malformation and Adult-Onset Chronic Diseases
Adult exposure to high fat diet (HFD) has been linked to increased risk of musculoskeletal, cardiovascular, and metabolic diseases; however, the contribution of gestational HFD to elevated oxidative stress (OS), perinatal cardiovascular, skeletal, and metabolic dysfunction as well as long-term …
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Determining the role of the LPI/GPR55 system in the development of obesity and associated cardiovascular consequences.
… mouse when challenged with a high fat diet (HFD) intervention, 2) elucidate any effect of the GPR55 knockout and HFD intervention on the myocardial infarct size sustained following a period of ischaemia/reperfusion (I/R) and 3) make use of an in vitro model to elucidate the mechanisms by …
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Maternal High Fat Feeding: Impact of Female Offspring Body Composition and Bone Health
High fat diet (HFD) consumption in rodents alters body composition and weakens bones. Whether female offspring of mothers consuming a HFD are similarly affected at weaning and early adulthood is unclear. This research determined whether maternal HFD contributes to long-lasting alterations in body …
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The Effect of Aberrant Inflammation During Pregnancy on Subsequent Risk of Maternal Metabolic Disease Development
… source of inflammation, such as a high fat diet (HFD). This led to the hypothesis that an inflammatory pregnancy complication followed by a HFD leads to the increased development of maternal metabolic disease. Also, that exposure to inflammation in utero followed by a HFD results in development of …
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Skeletal muscle metabolic adaptations in response to an acute high fat diet
… of an acute, five-day, isocaloric high fat diet (HFD) on skeletal muscle substrate metabolism in healthy non-obese humans. An additional purpose was to determine the effects of a HFD on gut permeability and blood endotoxins on healthy, non-obese, sedentary humans. Thirteen college age males were …
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Systemic Leptin Modulates the Expression of E-cadherin, β-catenin in the Ovary of Dietary-Induced Obese Infertile Rats
… regular chow diet (RCD) (n=6) or high fat diet (HFD) (n=14). Oestrus cycles were monitored daily until their cycles became irregular. 100 ug/ml of leptin was given intraperitoneally to HFD-fed rats (n=5) with irregular cycles. The control rats HFD (n=9) and RCD received saline. Leptin treatment …
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The impact of whey protein isolate on energy balance regulation
… whey protein isolate (WPI) enriched high fat (HFD) or low-fat diets (LFD), this study tested the hypothesis that WPI directly impacts on adiposity by influencing lipid metabolism. WPI suppressed HFD-induced body fat and increased lean mass at 8 weeks of dietary challenge despite elevated plasma …
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Circadian Flux of Extravascular Polymorphonuclear Leukocytes in the Mouse Limbus
… syndrome resulting from the consumption of a HFD is associated with circadian disturbances. The studies outlined in this thesis were designed to test the hypothesis that the circadian accumulation of PMNs at the limbus is depressed by consumption of a HFD. Aim 1 will determine if there is a …
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Impacts of dietary obesity on muscle stem cell behaviors
… mice normal chow (NC, control) or high-fat diet (HFD) for 10 wks and performed SC proliferation and differentiation assays in vitro. SCs from HFD mice formed colonies with smaller numbers (P < 0.001) compared to those isolated from NC mice, and this observation was confirmed (P < 0.05) by BrdU …
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High fat diet causes hepatic lipid accumulation by programming lipid synthesizing genes via gene body methylation
A high-fat diet (HFD) has been shown to cause more hepatic lipid accumulation as compared to a low-fat control (C) diet. However, it is still unclear what role epigenetic mechanisms play in hepatic lipid accumulation. We hypothesize that a HFD will cause greater hepatic lipid accumulation through …
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An investigation into the factors affecting the behaviour of Highway Filter Drains, with a particular emphasis on the Scottish Trunk Road Network
… asset takes the form of Highway Filter Drains (HFDs). However, despite their popularity, they are prone to clogging, therefore they have an estimated operational life-cycle of ten-years.This research was undertaken to investigate the complex inter-relationship between catchment characteristics, …
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Effects of diet and loss of ovarian hormone production on adiposity, inflammation, cecal integrity, and gut microbial communities of rodent models
… C57BL/6J mice in response to a high-fat diet (HFD). Forty 10-wk-old female C57BL/6J mice were fed either a high-fat diet (HFD; 60% kcal from fat) or a low-fat diet (LFD; 10% kcal from fat). After a 2-wk acclimation period, mice underwent surgical intervention (OVX or SHM). As expected, OVX mice …
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