Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"HERVS"”.
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Characterization of Human Endogenous Retrovirus sequences identifed in the human genome using the RetroTector software
Human Endogenous Retroviruses (HERVs) represent the inheritance of ancient germ-line cell infections by exogenous retroviruses and the subsequent transmission of the proviral integrated elements to the descendants. Actually, no replication-competent HERV sequence is recognizable in the human …
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Novel factors in the pathogenesis of cutaneous T cell lymphomas
… the activity of human endogenous retroviruses (HERVs) in CTCLs. HERVs are retroviral sequences comprising about 8% of the human genome and are derived from ancient retrovirus infections of germ line cells. HERVs have their own promoter areas and genes, some of which encode functional proteins. …
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The Detection and Role of Human Endogenous Retrovirus K (HML-2) In Rheumatoid Arthritis
… controls. In order to elucidate a clear role for HERVs in RA pathogenesis, autoantigens implicated in disease pathogenesis were scanned for sequence homology to retroviral genes. Such epitopes would induce antibodies cross reactive with host proteins, resulting in disease. Short peptides mimicking …
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Investigation of Endogenous Retroviruses in the Pathogenesis of Sporadic Amyotrophic Lateral Sclerosis (ALS) by
Human Endogenous Retroviruses (HERVs) are remnants of ancient retroviral infections that have become incorporated into the human genome over the course of our evolution as a species. These fossil viruses have been co-opted by our genome as regulators of cellular gene expression amongst various …
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The detection and role of human endogenous retroviruses in multiple sclerosis and other neurological diseases
Human endogenous retroviruses (HERVs) are estimated to form approximately 5% of the human genome. While the majority of sequences are defective, containing premature stop mutations and frameshift mutations, a number encode fully functional proteins. HERVs have been proposed as aetiological agents …
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Characterization of the human endogenous retrovirus HERV-‐K(HML-‐6) and HERV-‐K(HML-‐10) sequences and analysis of their expression
… and are termed human endogenous retroviruses (HERVs). After germ line infection, the retroviral DNA was integrated into the genome and transmitted through vertical transmission in the progeny by Mendelian laws. ERVs have been found in all vertebrates, indicating that the process of …
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
… options. Human endogenous retroviruses (HERVs) are retroviruses that have been incorporated into the human genome during evolution, now comprising 5% of it. The majority of HERVs are defective except for a few groups, including type K (HERV-K) which kept full-intact open reading frames. …
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Characterization of The Role(S) of Env Protein of Human Endogenous Retrovirus-K In Multiple Human Cancers
<p>Human endogenous retroviruses (HERVs) are remnants from ancient retroviral infections, and most of them are inactive in normal tissues. One family of HERV, HERV-K, is found to be associated with multiple human cancers including breast cancer, pancreatic cancer and melanoma, but the causal …
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Human Endogenous Retrovirus K As A Novel Tumor-Associated Antigen For Development of An Ovarian Cancer Vaccine
… that human endogenous retrovirus sequences (HERVs) may play a role in the etiology of certain cancers. In a previous study, we showed that HERV-K envelope (env) proteins are widely expressed in human invasive breast cancer (BC) and ductal carcinoma in situ (DCIS), and elicit both serologic …
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Avian leukosis virus as a risk factor for ovarian adenocarcinoma in layer hens
… Recently, human endogenous retroviruses (HERVs) have been shown to be associated with ovarian cancer in women. Hens also have endogenous retroviruses, notably Avian Leukosis Virus E (ALV-E). The link between ALV-E and OAC in hens has not been adequately investigated. ALV infection in hens …
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From Fossils to Function: Exploring the Evolutionary And Functional Diversity Of HERV Envelope Proteins Across Primate Lineages
… from ancestral proteins of Class I, II, and III HERVs and analyzed them using similarity searches, phylogenetic analysis, and recombination studies across 43 primate species in the Catarrhini and Platyrrhini parvorders. The findings indicate that ERVs are widely distributed throughout the primate …
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Contributions of viral and cellular gene products to the pathogenesis and prognosis of aggressive lymphomas
High grade aggressive lymphomas have high mortality. By their nature, more than 40% of patients die from these diseases even with the improved treatment strategies currently available for oncology patients. The characteristic feature is that they are functionally heterogeneous and therefore have …