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Showing 1 to 17 of 17 for “"HERV-K"”.
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Characterization of the human endogenous retrovirus HERV-‐K(HML-‐6) and HERV-‐K(HML-‐10) sequences and analysis of their expression
… and are termed human endogenous retroviruses (HERVs). After germ line infection, the retroviral DNA was integrated into the genome and transmitted through vertical transmission in the progeny by Mendelian laws. ERVs have been found in all vertebrates, indicating that the process of …
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Expression and Immunological Characterization of Herv-K Transmembrane Envelope Protein In Human Breast Cancer
<p>The human endogenous retrovirus K (HERV-K) <em>env</em> gene encodes envelope protein comprising surface (SU) and transmembrane (TM) domains. Having shown the exclusive expression of SU in human breast cancer and the stimulation of SU-specific immune responses in patients with breast cancer, our …
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Aktivität endogener Retroviren in Tumorgeweben von Primaten
Die humanen endogenen Retroviren der Familie K (HERV-K) sind eine evolutionär junge Gruppe von retroviralen Sequenzen. Im Gegensatz zu anderen endogenen Retroviren sind einige der HERV-K Proviren replikationskompetent und besitzen komplette offene Leserahmen für retrovirale strukturelle und …
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Targeting An Ancient Retrovirus During Melanoma Using Adoptive T Cells Therapy
… TAA derived from human endogenous retroviruses (HERV), whose genome stably integrated into humans millions of years ago. During oncogenesis, biologically active variants of HERV, such as the envelope (env) protein of HERV-K, are expressed on the surface of melanoma, but not normal cells. To …
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
… options. Human endogenous retroviruses (HERVs) are retroviruses that have been incorporated into the human genome during evolution, now comprising 5% of it. The majority of HERVs are defective except for a few groups, including type K (HERV-K) which kept full-intact open reading frames. …
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Human Endogenous Retrovirus K As A Novel Tumor-Associated Antigen For Development of An Ovarian Cancer Vaccine
… that human endogenous retrovirus sequences (HERVs) may play a role in the etiology of certain cancers. In a previous study, we showed that HERV-K envelope (env) proteins are widely expressed in human invasive breast cancer (BC) and ductal carcinoma in situ (DCIS), and elicit both serologic …
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Transcriptional Heterogeneity in ALS: Patients with Retrovirus-mediated Disease and Potential Cell-type Specific Therapeutic Approaches
… associated with human endogenous retrovirus K (HERV-K), a type of transposable element (TE), as well as other non-TE features were dysregulated in patient samples compared to controls. In both the CTX and SC, around 20% of ALS patients had higher overall HERV-K expression than other patients and …
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Characterization of The Role(S) of Env Protein of Human Endogenous Retrovirus-K In Multiple Human Cancers
<p>Human endogenous retroviruses (HERVs) are remnants from ancient retroviral infections, and most of them are inactive in normal tissues. One family of HERV, HERV-K, is found to be associated with multiple human cancers including breast cancer, pancreatic cancer and melanoma, but the causal …
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Insertionally polymorphic human endogenous retroviruses and their potential role in cancer
… this study a family of endogenous retroviruses, HERV-K(HML-2) was investigated. The family is the youngest endogenous retrovirus family known in humans, with some of its members being insertionally polymorphic in modern human populations. There have been numerous reports of HERV-K(HML-2) members …
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Evidence of Human Endogenous Retrovirus K Involvement In Human Cancer
… the presence of human endogenous retrovirus K (HERV-K) Env viral RNA (vRNA), protein, and viral particles. We hypothesize that HERV-K proteins are tumor-associated antigens and as such can be profiled and targeted in patients for diagnostic and therapeutic purposes. To test this hypothesis, we …
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The Detection and Role of Human Endogenous Retrovirus K (HML-2) In Rheumatoid Arthritis
… which has been associated with an increase in HERV expression, compared to controls. In order to elucidate a clear role for HERVs in RA pathogenesis, autoantigens implicated in disease pathogenesis were scanned for sequence homology to retroviral genes. Such epitopes would induce antibodies …
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Reconstitution and Characterization of Human Endogenous Retrovirus-K
… there is no known replication competent HERV, as most proviruses are filled with deletions and premature stop codons. However, one family of Class II HERV, HERV-K(HML-2), seems to have been replicating until recently. The HERV-K(HML-2) family includes human specific members and elements …
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Investigation of Endogenous Retroviruses in the Pathogenesis of Sporadic Amyotrophic Lateral Sclerosis (ALS) by
Human Endogenous Retroviruses (HERVs) are remnants of ancient retroviral infections that have become incorporated into the human genome over the course of our evolution as a species. These fossil viruses have been co-opted by our genome as regulators of cellular gene expression amongst various …
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THE EFFECT OF INDOOR TOTAL SUSPENDED PARTICLES (TSP) ON THE HUMAN UPPER RESPIRATORY SYSTEM: FROM THE MICROBIOME TO HERV METHYLATION
… elements integrated in our genome, the HERV genes. These genes regulate essential processes, and their dysregulation is associated with various inflammatory and immune-related diseases. The aim of this project is to investigate the effects of indoor Total Suspended Particles (TSP) on the …
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From Fossils to Function: Exploring the Evolutionary And Functional Diversity Of HERV Envelope Proteins Across Primate Lineages
… investigate the tropism of ancestral and current HERV Env proteins. The first part of the project focused on the HERVK(HML2) group, which is significant due to its recent integration into the human genome and its functional conservation. While ERVs are found in all vertebrates, HERV-K is specific …
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HUMAN GENOME VARIATIONS AND EVOLUTION WITH A FOCUS ON THE ANALYSIS OF TRANSPOSABLE ELEMENTS
… in some families, e.g., L1, Alu, SVA, and HERV-K, remaining active for transposition. Along with other types of genomic variants, retrotransponson-derived variants contribute to the whole spectrum of genome variants in humans. With the advancement of sequencing techniques, many human …
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Bioinformatic methods in mammalian genomics: applications towards conservation and health
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms