Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"HER3"”.
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Identifikation signaltransduktionsrelevanter Gene in Melanom-zelllinien durch Entwicklung und Anwendung eines Verfahrens zur Analyse von Daten aus cDNA-Hybridisierungsarrays
… wurde gefunden, dass bei ADAM-9, ADAM-10, HER3, FAK, SHC und dem IGF-1-Rezeptor die Unterschiede der Expression zwischen Melanomzelllinien und Melanozyten besonders ausgeprägt waren. Bei weiteren Genen wurden schwächer ausgeprägte, jedoch ebenfalls interessante Expressionsmuster beobachtet. …
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An optical proteomic profile of the HER2 family in breast tumours and the effect of exposure to tyrosine kinase inhibitors
… inevitably develops to both drugs. HER2:HER3 dimerisation is vital to the translation of extracellular signals, via intracellular signaling cascades, to promote cancer cell proliferation, invasion and metastasis, and is studied herein. Regulation of the amplitude and kinetics of signal …
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Modulating cell behavior with engineered HER-receptor ligands
… growth factor receptor (EGFR or HERI), HER2, HER3 and HER4 - influence processes as diverse as development, wound healing, migration, and tissue homeostasis and family members are expressed by almost every cell type. All HER receptors require either homodimerization or heterodimerization with …
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The role of EGFR, HER 2-4, heregulin and downstream signalling in prostate adenocarcinoma
… of the HER tyrosine kinase family - EGFR, HER2, HER3 and HER4 - during disease progression in prostate adenocarcinoma is conflicting – both poor prognosis and no influence on outcome are reported. A small cohort pilot study of paired hormone sensitive (HSPC) and refractory (HRPC) specimens …
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Development of novel RNA- and protein-based cancer therapeutics by either silencing of potential oncogenes or active restoration of a tumor suppressor gene
… also used A30, a novel RNA aptamer that binds to HER3 expressed on MCF-7 cells. This is the first study demonstrating the specific binding of A30 to HER3-expressing MCF-7, cells as well as its subsequent internalization. In agreement with the results obtained by McNamara et al., this thesis …
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Integrin-Mediated Mechanotransduction Controls Activation of Yap and Invasive Growth of Breast Cancer
… of HER2+ breast cancer cells. Engagement of HER2/HER3 with neuregulin impinges on SFKs to amplify activation of YAP in HER2+ breast cancer cells, suggesting that integrin-mediated mechanotransduction functions as a rheostat to regulate HER2 oncogenic signaling. Finally, administration of Dasatinib …
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Identification of novel determinants of primary and acquired resistance to EGFR-targeted therapies in colorectal cancer
… allowed us to establish a potential role for the HER3 RTK in cetuximab resistance within this cell line. This role of HER3 was further confirmed when siRNA silencing of the receptor was determined to abrogate the reactivation of ERK1/2 phosphorylation mediated by cetuximab treatment. We therefore …
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Design and development of novel tools for the screening and identification of inhibitors of HER receptor family and NFR2 for ovarian cancer therapy
… resulted in the repression of HER1, HER2, HER3 and HER4 expression, inhibition of NRF2, elevation of ROS, depletion of glutathione and enhanced cytotoxicity in PEO1, OVCAR3, SKOV3 and MCF7-AREc32 cell lines. This explained the crosstalk mechanism between HER receptor family and NRF2 and the …
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Expression of Epidermal Growth Factor Receptor in hypopharyngeal cancer and Effect of EGF in Progression of hypopharyngeal cancer
… proteins, which also includes HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4). High levels of EGFR expression are correlated with poor prognosis and resistance to radiation therapy in a variety of cancers, mostly in head and neck squamous cell carcinoma (HNSCC). So we examined the expression of …
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Rational design, characterization and in vivo studies of antibody mimics against HER2
… inhibit the dimerization between HER2 and HER3 to block phosphorylation of Akt pathway in a similar way as Pertuzumab. In addition, in vivo studies on tumor bearing nude mice were carried out to investigate the distribution and binding specificity of antibody mimics towards HER2 positive …
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Development and Evaluation of Novel Anti-HER2 Theranostics Against HER2-Positive Breast Cancer
… itself or other HER family members (HER1/EGFR, HER3 and HER4), initiating downstream signalling pathways that regulate the proliferation, differentiation and growth of cancer cells. In the past 20 years, remarkable advancements have been achieved in developing treatments against HER2-positive …
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Διερεύνηση μοριακών προγνωστικών παραγόντων στον καρκίνο του παχέος εντέρου
Ο καρκίνος του παχέος εντέρου αποτελεί ένα από τα συχνότερα κακοήθη νεοπλάσματα παγκοσμίως, προκαλώντας σημαντική νοσηρότητα και θνητότητα. Η συστηματική διερεύνηση της παθογένειας συντελεί σημαντικά στην πρόληψη, έγκαιρη διάγνωση, θεραπεία και πρόγνωση της νόσου. Στην εποχή της μοριακής ιατρικής, …