Global ETD Search
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Showing 1 to 2 of 2 for “"HEAT repeats"”.
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Structural and Biochmical Studies of Nuclear Import Factor Karyopherin Beta-2
… divided into three major segments. Two of them (HEAT repeats 9- 13 and 14-18), which constitute the substrate binding site, are rigid elements that rotate relative to each other about a flexible hinge. The third (HEAT repeats 1-8), which constitute the Ran binding site, exhibits conformational …
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Structure-Function Analysis of Human Integrator Subunit-4
… function for Symplekin due to the presence of HEAT repeat motifs in its N-terminus. Based upon the structural similarity between IntS4 and Symplekin, <strong><em>we hypothesized that Integrator subunit 4 may be behaving as a Symplekin-like scaffold molecule that facilitates the interaction …