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Showing 1 to 3 of 3 for “"HDQ"”.
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Inhibition of the Toxoplasma gondii replication by inhibition of the mitochondrial respiratory chain
… Die Substanz 1-Hydroxy-2-Dodecyl-4(1)-Quinolon (HDQ) ist in Enzymassays als hoch affiner Inhibitor der alternativen NADH-Dehydrogenase des Hefepilzes Yarrowia lipolytica beschrieben worden. HDQ ist außerdem in der Lage, das Wachstum von P. falciparum und Genotyp-I-Parasiten von T. gondii in der …
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Biochemical Characterization of <i>Toxoplasma gondii</i> Type II NADH Dehydrogenases - Physiological Impact on Mitochondrial Functions and Energy Metabolism
… compound 1-hydroxy-2-alkyl-4(1)quinolone (HDQ), known as a high affinity inhibitor for Yarrowia lipolytica NDH2, has been shown to effectively inhibit the replication of T. gondii. To obtain biochemical evidence that TgNDH2s are the targets for HDQ, both TgNDH2 isoforms were heterologously …
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Characterization of alternative NADH dehydrogenases in the respiratory chain of Toxoplasma gondii as a novel drug targets
… Verbindung 1-hydroxy-2-dodecyl-4(1)quinolone (HDQ) wurde vor kurzem als hoch-affiner Inhibitor Alternativer NADH Dehydrogenasen in Pilzen beschrieben. Die Hemmung durch HDQ konnte in enzymatischen Assays gezeigt werden, wobei der Inhibitor wahrscheinlich mit der Ubiquinol Bindungsstelle des …