Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"HDPs"”.
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Host Defence Peptides (HDPs): investigating the structure-to-function relationship through bio-physical techniques
… a vast range of both natural and synthetic HDPs sequences are reported in the literature but they still present remarkable limitations to an effective applicability in vivo, such as the high sensitivity to proteases and strong activity reduction in the presence of physiological electrolytes …
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Developmental gene expression of host defense peptides in immune organs and the small intestine of turkey poults (Meleagris gallopavo)
Host defense peptides (HDPs) are a large group of small positively charged peptides that play an important role in innate immunity. Their role is more critical at early ages when other components of the immune system have not fully developed. There are three classes of avian HDPs: avian beta …
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Targeting bacterial infections by using immunomodulatory host defence peptides and proteins
… usage. Endogenous host defence peptides (HDPs) are essential components of the innate defence against invading pathogens. They exert multiple biological functions, and apart from their antimicrobial effects they may modulate inflammation, coagulation, and chemotaxis. Due to increasing …
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On the discovery and biological characterization of porcine β-Defensin 5 (pBD-5)
… faces in the XXI century. Host defense peptides (HDPs), such as porcine β-defensins (pBDs), have gained attention for their immunomodulatory, microbiome-modulating, and antimicrobial properties. This thesis describes the discovery, synthesis, and biological characterization of a novel porcine …
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HOST DEFENSE PEPTIDES OF THE COAGULATION SYSTEM AND THEIR THERAPEUTIC POTENTIAL
… evidence suggests that host defense peptides (HDPs) may be potential lead structures in sepsis treatment due to their ability to modulate innate immune responses as well as being directly antimicrobial. From that perspective, this thesis aimed to identify and characterize the structure-activity …
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A molecular investigation of the antimicrobial functions of the human S100 host-defense proteins
… release of antimicrobial host-defense proteins (HDPs). The goal of this thesis is to understand the antimicrobial functions of four host-defense proteins of the S100 family of proteins: calprotectin (CP), S100A12, S100A7, and S100A15. In the first half of this thesis, we elucidate the …
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Temporal and Tissue Specific Changes in Expression of Nutrient Transporters and Host Defense Peptides in Young Broilers during Salmonella and Campylobacter infections
… nutrient transporters and host defense peptides (HDPs) during a Salmonella or a Campylobacter challenge in young commercial broilers. Comparisons were made between non-challenged and challenged (106, 107, or 108 colony forming units of Salmonella or Campylobacter) broilers on expression of …
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The Role of MRGPRX2/Mrgprb2 in Regulating Mast Cell Function
… ic"drugs"and"host"defense"peptides"such"as"LL_37."HDPs"also" known" as" antimicrobial" peptides" (AMPs)" have" been" investigated" in" depth" as" an" alternative"to"overcome"antibiotic"resistance"crisis."However,"their"susceptibility"to" …
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Examining the interrelationship between competition law, the allocation of fishing rights, and transformation in South Africa’s fishing industry
… past imbalances and broadening participation of HDPs in the fishing sector. The fishing industry is also a strategic sector for food security and employment. The Competition Act and the MLRA, not only intersect by virtue of commercial and small-scale fishing qualifying as economic activities, but …
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Epidermicin NI01 and human β-defensin 2 as modulators of macrophage subset responses
… peptides (AMPs) and host defence peptides (HDPs) have been extensively investigated for their antimicrobial activity and evidence suggests that they can also modulate the host immune system. However, little is known about their effects on macrophages, a key cell population in inflammatory …
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Exploration of innate immune response during infectious bovine digital dermatitis and the evaluation of topical therapeutic treatment
… description of bovine host defence peptides (HDPs) and their contribution to disease resolution are found herein. It was observed that active DD was characterized by necrotic tissue populated with neutrophils and elevated Cxcl-8 and Tlr4 expression. Tracheal antimicrobial peptide (Tap) was …
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Cellular Events During Coccidial Infection in Chickens
… performed. Expression of host defense peptides (HDPs), apoptosis and autophagy related genes were examined in Eimeria challenged broilers. The results showed that upon Eimeria infection, LEAP2 was consistently downregulated in the target tissues, while the avian beta-defensins (AvBDs) showed many …