Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"HDMEC"”.
-
An investigation into the molecular mechanisms of hyperbaric oxygen using a human dermal microvascular endothelial cell line and a porcine retinal explant model.
… on human dermal microvascular endothelial cells (HDMEC) and porcine retinal vasculature is presented with three mechanistic pathways of transcriptional factors regulating the redox (nuclear factor type-2 (Nrf2)), pro-inflammation (Nuclear Factor kappa B; (NFᴋB)), and oxygen signalling (hypoxia …
-
Regulation of VEGF-activated signalling by the plasma membrane calcium ATPase 4 in endothelial cells
… validated by TaqMan-based qPCR in HUVEC or HDMEC. RNA levels of PMCA4 in aging HUVEC were analysed by TaqMan qPCR using RNA isolated from HUVEC cultured from different passages (from 3 to 15 passages). RESULTS: siRNA-mediated PMCA4 knockdown led to increased expression of Notch ligand DLL1 …
-
Design of a Gel-in-Scaffold Hybrid Substrate for a Multicellular Endometrial Model
… of human dermal microvascular endothelial cells (HDMECs) was compared across different substrate systems with pre-seeded HDFs. In CG substrates, significant gel shrinkage was observed, along with limited HDMEC infiltration and no observable vessel formation. In S substrates, HDMECs directly …
-
Untersuchungen zur antiangiogenen Aktivität des matrizellulären Proteins Thrombospondin-2
… Behandlung von mikrovaskulären Endothelzellen (HDMEC) mit NTF-TSP-2 führte zu einer deutlichen Hemmung der VEGF-induzierten Ausbildung von Endothelzellröhren. Durch die systemische Gabe von NTF-TSP-2 wurden das Tumorwachstum und die Angiogenese von xenotransplantierten Mammakarzinomzellen …
-
PEGylated Tissue Repair Peptide TP508 Derivatives as Second Generation Drugs for Radiomitigation and Other Systemic Applications
… in human dermal microvascular endothelial cells (HDMEC) where TP508 and its derivatives accelerated repair of radiation induced DNA double strand breaks. To test in vivo activity, murine models for mitigation of ionizing radiation using outbred male CD-1 mice were used. These studies demonstrated …
-
Functional Significance of the Upregulation of Adhesion Molecules on Irradiated Endothelial Cells
… (HUVEC), human microvascular endothelial cells (HDMECs) and transformed microvascular endothelial cells (HMEC-1) at 5 hr, 24 hr, 48 hr and 72 hr post-irradiation. We have also developed an in vitro flow model to study the functional consequences of the radiation induced upregulation of adhesion …
-
Fabrication and Optimisation of Collagen Scaffolds for Muscle Cell-Supported Angiogenesis
… and human dermal microvascular endothelial cell (HDMEC) behaviour was evaluated in human skeletal muscle cell (HSkMC)-seeded scaffolds. The internal architecture of porous scaffolds is known to influence cell outcomes; therefore, control of structure via the fabrication process is highly …
-
Effects of Surface Characteristics of Hydroxyapatite and Substituted Hydroxyapatites on Protein Attachment and Angiogenesis
… human dermal microvascular endothelial cells (HDMECs), with- and without FN pre-coating. A hOB:HDMEC cell ratio of 70:30 was found to promote vessel formation on all biomaterials. 1.25wt%Si-HA and Bio-Oss® discs were the most and least bioactive of all three samples, respectively, and …