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Showing 1 to 3 of 3 for “"HDM2/P53"”.
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Computational approaches for drug design at the Protein-Protein interface
… to the above questions we then investigate the hDM2-p53 system which when disrupted can induce apoptosis in many forms of cancer, making it a target of considerable interest to the pharmaceutical industry. Molecular docking is exploited in order to generate likely structural conformations of …
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Hdm2 Small-Molecule Inhibitors For Therapeutic Intervention In B-Cell Lymphoma
<p>Lymphomas frequently retain wild-type (wt) p53 function but overexpress HDM2, compromising p53 activity. Therefore, lymphoma is a suitable model for studying therapeutic value of disrupting HDM2-p53 association by small-molecule inhibitors (SMIs). HDM2 SMIs have been developed and are currently …
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Expanding the Spiroligomers Toolbox as Protein-Protein Interaction Inhibitors
… spiroligomers that mimic the helical domain of p53 was undertaken before each molecule was tested for binding to HDM2, a natural binding partner of p53. A library of molecules was synthesized on solid support that altered the stereochemistry along the spiroligomer as well as the presented …