Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"HDM2"”.
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Hdm2 Small-Molecule Inhibitors For Therapeutic Intervention In B-Cell Lymphoma
… wild-type (wt) p53 function but overexpress HDM2, compromising p53 activity. Therefore, lymphoma is a suitable model for studying therapeutic value of disrupting HDM2-p53 association by small-molecule inhibitors (SMIs). HDM2 SMIs have been developed and are currently under various stages of …
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Role of hnRNP A1 in the Regulation of HDM2 Gene Expression
… 2,10. Our preliminary data showed that <em>HDM2</em> mRNA associates with hnRNPA1 in IMR-90 cells. We have also observed that alterations of hnRNP A1 expression can modulate <em>HDM2</em> mRNA levels. HDM2 expression must be regulated in normal and stressed cells to maintain normal p53 …
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p53 nuclear localization control, and p53-dependent regulation of DNA repair gene transcripts
… had suggested that the p53 negative regulator HDM2 was a nucleocytoplasmic shuttling protein that binds and carries p53 from the nucleus of the cell to the cytoplasm where it is destroyed by the proteasome. We determined that HDM2 with a mutated nuclear export sequence was still able to able to …
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Synthesis of biologically active heterocyclic compounds
… replication. This function is carried out by the HDM2 protein, which forms an auto-regulatory feedback loop with p53. In some tumours, the p53 function is disrupted due to genetic mutations of p53. However other tumours possess ‘wild type’ p53 – this type of p53 has lost the ability to respond to …
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Role of Hypoxia-inducible Factor in Kidney Cancer
… leads to Akt-mediated hyperactivation of Hdm2, resulting in decreased activity of p53 and increased resistance to apoptosis. Significantly, we show that restoration of p53 activity via inhibition of Hdm2 reverses chemoresistance of otherwise refractory ccRCC cells. We also demonstrate that …
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Computational approaches for drug design at the Protein-Protein interface
… to the above questions we then investigate the hDM2-p53 system which when disrupted can induce apoptosis in many forms of cancer, making it a target of considerable interest to the pharmaceutical industry. Molecular docking is exploited in order to generate likely structural conformations of …
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THE ROLE OF DMP1 IN HUMAN BREAST CANCER PROGNOSIS AND CYCLIN D1-INDUCED BREAST CANCER
… longer relapse-free survival. Conversely, both Hdm2 amplification and p53 LOH were associated with shorter survival, while the LOH of INK4a/ARF had no prognostic value in breast cancer.
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Expanding the Spiroligomers Toolbox as Protein-Protein Interaction Inhibitors
… before each molecule was tested for binding to HDM2, a natural binding partner of p53. A library of molecules was synthesized on solid support that altered the stereochemistry along the spiroligomer as well as the presented functional groups. It was determined that spiroligomers enter human …