Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"HDACi"”.
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Proteins Involved in HDACi Induced Decay of ERBB2 Transcripts in Breast Cancer
… to these agents. Histone deacetylase inhibitors (HDACi) are a powerful new class of epigenetic therapeutics that have demonstrated potent antitumor activity. However, there are several concerns that need to be addressed regarding the clinical usage of pan-HDACi therapeutics, such as the standard …
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Oxidative Stress Based Strategies For Enhancing The Efficacy of Histone Deacetylase Inhibitors (Hdaci)
<p>Histone deacetylase inhibitors (HDACi) are anti-cancer drugs that primarily act upon acetylation of histones, however they also increase levels of intracellular reactive oxygen species (ROS). We hypothesized that agents that cause oxidative stress might enhance the efficacy of HDACi. To test …
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Genomic Analysis of Chemo-Resistance to HDAC inhibitor in Gastric Cancer cells
Histone deacetylase inhibitors (HDACis) are a promising class of anticancer epigenetic drugs, however, molecular factors influencing the responses of individual tumors to HDACi therapies remain obscure. Here, we sought to identify genes associated with HDACi resistance in gastric cancer. Treating a …
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Targeting Histone Deacetylases (Hdac) For The Treatment of Soft Tissue Sarcoma
… <p>Histone deactylase inhibitors (HDACi) are a new class of anticancer therapeutics; however, little is known about HDACi or the individual contribution of HDAC isoform activity in soft tissue sarcoma (STS). We investigated the potential efficacy of HDACi as monotherapy and in …
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Post-translational modifications of c-FLIP: opportunities for therapeutic intervention
… regulation in NSCLC cell lines. Treatment with HDACi induced apoptosis in a time- and dose-dependent manner concomitant with activation of caspases. However, normal cells were unaffected by treatment with HDACi, suggesting these agents might provide a good therapeutic window. Silencing …
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Integration of class 1 HDAC inhibitors into current treatments for prostate cancer
… clinical targets. Although five HDAC inhibitors (HDACi) have been FDA approved for myelodysplastic syndromes, evaluation of pan-HDACi in CaP clinical trials as single agents have been ineffective to date largely due to treatment-related toxicity and efficacy as monotherapies. To be able to …
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MOLECULAR STUDY OF CHROMATINOPATHIES: THE CASE OF RUBINSTEIN-TAYBI AND RETT SYNDROMES
… tested exogenous histone deacetylase inhibitors (HDACi) in in vitro cellular models (lymphoblastoid cell lines derived from patients and healthy donors) and on a Drosophila melanogaster model of RSTS (nej) and wild type flies (yw), performing acetylation and viability assays and flies embryos …
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Entwicklung eines HTS-geeigneten Enzymtests für Histondeacetylasen zur Entwicklung von HDAC-Inhibitoren
… in der Entwicklung von HDAC-Inhibitoren (HDACI), wie auch insgesamt bei der biochemischen Charakterisierung dieser Enzymfamilie dar. Im Rahmen dieser Arbeit wurde der erste HTS-geeignete, homogene, Fluoreszenz-basierte HDAC-Assay entwickelt, welcher in einem zweistufigem Prozess ein …
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Therapeutic testing and epigenetic characterization of Friedreich Ataxia
… the use of histone deacetylase inhibitors (HDACi) as FXN up-regulators. Therefore, therapy with a benzamide-type HDACi (106) was similarly investigated on the FXN YAC GAA mouse model. No significant improvements were detected by functional and histochemical analysis. However, significant …
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Defining The Role of Egfr Acetylation In Cellular Processes: Clinical Implications
… may contribute to HDAC inhibitors (HDACi)-augmented EGFR phosphorylation.</p> <p> In this investigation, we showed that CBP acetyltransferase acetylated EGFR <em>in vivo</em>. In response to EGF stimulation, CBP rapidly translocated from the nucleus to the cytoplasm. We also …
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Epigenetic Changes in Alzheimer’s and Huntington’sS Disease : A semi-quantitative analysis of histone changes
… pathogenesis. The use of HDAC inhibitors (HDACi) to restore histone acetylation levels and gene expression of downregulated genes has shown promise in these models but so far not in the clinic. Furthermore the state of histone acetylation in human HD and AD brain has not been previously …
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EFFECTS OF HISTONE DEACETYLASE INHIBITORS ON ENERGY METABOLISM
… with pan and class selective HDAC inhibitors (HDACi), such as SAHA(pan-inhibitor), MS275 (Class I HDAC inhibitor) and MC1568 (Class II HDAC inhibitor), transcriptome analysis revealed an increase of OXPHOS genes and of genes encoding fatty acid catabolic enzymes, following treatment with pan or …
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Isoform-Selective HDAC Inhibition for the Treatment of Lupus Nephritis
… treatment with a class I and II HDAC inhibitor (HDACi) or a specific HDAC6i would be able to ameliorate disease in lupus-prone NZB/W mice. We found that both the class I and II HDACi (ITF2357) and the HDAC6i (ACY-738) were able to decrease SLE markers of disease including splenomegaly, …
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The Role of Short-Chain Fatty Acids on Intestinal Epithelial Cell Migration
… migration in a histone deacetylase inhibition (HDACi) and GPR43 dependent manner allows for further targeting of these pathways to circumvent some of the current pitfalls of SCFAs, mainly their ability to inhibit epithelial proliferation, which could be detrimental to ulcer healing.
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Definition of The Landscape of Chromatin Structure At The Frataxin Gene In Friedreich’S Ataxia
… that specific histone deacetylase inhibitors (HDACi) affect either histone modifications at the <em>FXN</em> gene or <em>FXN</em> expression in FRDA cells, indicating that the hyperexpanded GAA repeat may facilitate heterochromatin formation. However, the correlation between chromatin structure …
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Leveraging Single Cell Technologies For The Characterization and Treatment of Refractory Pancreatic Cancer
… agents (HDAC inhibitors). I describe a novel HDACi resistance mechanism of AP1 activation, which can be intercepted by using an AP1 inhibitor in combination with an HDAC inhibitor to achieve tumor cell death. Finally, in an effort to explore and characterize the molecular consequences of …
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MEMORY TH17 CELLS IN THE LUNG DURING SECONDARY BACTERIAL PNEUMONIA FOLLOWING INFLUENZA A VIRUS INFECTION
… an FDA approved histone deacetylase inhibitor (HDACi), Romidepsin (RMD), acts as a novel adjuvant to augment antigen-specific Th17 responses in the lung and improve immunization-induced protection against co-infection. Animals immunized with vaccine adjuvanted with RMD display increased …
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Identification of substrate-selective histone deacetylases and their inhibitors that mediate HER2 transcript stability
… levels and acetylation status before and after HDACi treatment, and their functional impact on HER2 mRNA by modulating its expression levels. Understanding the mechanism by which optimal class-selective HDAC inhibitors modulate translation-associated proteins to facilitate HER2 mRNA degradation …
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Human Organotypic Retinal Cultures as a model of human retinal ganglion cell degeneration in glaucoma. Effects of epigenetic regulation and mesenchymal stem cell derived growth factors.
… altered by the histone deacetylase inhibitor (HDACI) trichostatin A (TSA). Conclusions: The timing for long-term HORCs use ex vivo is dependent on culture conditions. Long-term HORCs can be used for up to 2 weeks in order to prevent detectable RGC loss. Both VEGF and PDGF possess an ability to …
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Ligandi ibridi Sigma-HDAC come potenziale trattamento terapeutico per il melanoma uveale: design, sintesi e valutazione biologica
… che sull’HDAC come inibitori (l’uso di alcuni HDACi è già ampiamente convalidato come antitumorali).
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