Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"HDAC9"”.
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Defining the potential of HDAC5 and HDAC9 as therapeutic targets for Parkinson’s disease
… inhibition of Class IIa HDACs, HDAC5 and HDAC9 have demonstrated some positive preliminary findings in PD models. Therefore, this thesis aims to better understand the therapeutic potential of the inhibition of these HDACs in the PD context. To do this, we utilised both pharmacological …
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Preclinical evaluation of a novel AAV-GDF5 vector in a 6-OHDA model of Parkinson’s disease and evaluation of the effect of 6-OHDA on the expression of HDACs
… 5 and 9 expression in the rat brain. HDAC5 and HDAC9 are of particular interest to our group as our group has shown that their expression correlates with three markers of dopaminergic neurons in both the mouse and human substantia nigra. HDAC3 was also selected as an example of a different HDAC …
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Roles of Class II Histone Deacetylases in the Cardiovascular System
… mutant mice is remarkably similar to that of HDAC9 mutant mice, strongly suggesting that these two HDACs play comparable roles in the control of cardiac growth. HDAC 5 and 9 also appear to play overlapping roles during heart development, as evidenced by cardiac malformations that occur in mice …
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Isoform-Selective HDAC Inhibition for the Treatment of Lupus Nephritis
… C57BL/6 control mice. Expression of HDAC6 and HDAC9 were significantly increased in all of the tissues tested from MRL/lpr mice. Furthermore, both cytoplasmic and nuclear HDAC activity was increased in diseased MRL/lpr mice, and HDAC activity and expression continued to increase as disease …
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Cellular and Molecular Mechanisms Governing Intramuscular Fat Development and Growth in Cattle
… in IMF compared to SF, such as FOXO6, SLC27A1, HDAC9, and PIK3C2A, were associated with negative regulation of adipogenesis, while several genes downregulated in IMF, such as FABP4, AGPAT2, and PLIN2, were key promoters of adipocyte differentiation. Functional enrichment analysis revealed that …