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Showing 1 to 7 of 7 for “"HDAC6 inhibition"”.
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Selective HDAC6 Inhibition in Systemic Lupus Erythematosus
… SLE with promising results, however selective HDAC6 inhibition (HDAC6i) has become a leading candidate for pharmacologic inhibition to reduce the potential for side effects. We hypothesize that HDAC6i will decrease SLE disease by targeting substrates of HDAC6 in multiple components of immunity …
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Computational and Pharmacological Characterization of HDAC6 Inhibition and Function
HDAC6 is a unique histone deacetylase. It contains two catalytic domains, of which they act independently or in tandem. It belongs to the class IIb HDACs and is Zn2+ dependant. It has been seen to be involved in various diseases such as diabetic neuropathies and certain cancers including breast …
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Hdac6 Inhibition Reverses Long-Term Doxorubicin-Induced Cognitive Dysfunction By Restoring Microglia Homeostasis
… barrier permeable histone deacetylase 6 (HDAC6) inhibitor successfully reverses long-term CICD following a therapeutic doxorubicin dosing schedule in female mice, as assessed by the puzzle box test and novel object/place recognition test. Long-term CICD was associated with a decreased …
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Selective histone deacetlyase inhibition decreases disease in lupus-prone mice
Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that acetylates several proteins that are involved in the immune response. HDAC6 inhibition has been shown in various models to decrease inflammation by altering various proteins involved in the dysregulation of B and T cell responses. In our …
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The Role of Histone Deacetylase 6 Inhibition on Systemic Lupus Erythematosus
… the use of current ones. Histone deacetylase 6 (HDAC6) plays a variety of biologic functions in a number of important molecular pathways in diverse immune cells. Both innate and adaptive immune cells contribute to pathogenesis of lupus. Among those cells, B cells play a central role in …
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HDAC6 Deletion Decreases Pristane-Induced Inflammation and Lupus
… 6 is a class IIb histone deacetylase member. HDAC6 has the ability to catalyze the removal of acetyl groups from lysine residues on non-histone proteins. It has been observed that in lupus mouse models, specific HDAC6 inhibition reduces inflammation. Administration of pristane, a naturally …
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Nuove strategie per revertire la chemioresistenza nel Mieloma Multiplo
Il mieloma multiplo è una malignità ematologica caratterizzata da plasmacellule a differenziazione terminale, immunosoppressione e danno agli organi finali, comprese le lesioni osteolitiche. I pazienti presentano tipicamente infiltrazione midollare di plasmacellule clonali e proteine monoclonali …