Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"HDAC6"”.
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Selective HDAC6 Inhibition in Systemic Lupus Erythematosus
… SLE with promising results, however selective HDAC6 inhibition (HDAC6i) has become a leading candidate for pharmacologic inhibition to reduce the potential for side effects. We hypothesize that HDAC6i will decrease SLE disease by targeting substrates of HDAC6 in multiple components of immunity …
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Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis
… growth.</p><p>In this thesis, I have showed that HDAC6, a cytoplasmic localized and cytoskeleton-associated deacetylase, is required for efficient oncogenic transformation and tumor formation. I have found that HDAC6 expression is induced upon oncogenic Ras-induced transformation in both human …
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HDAC6 Deletion Decreases Pristane-Induced Inflammation and Lupus
… 6 is a class IIb histone deacetylase member. HDAC6 has the ability to catalyze the removal of acetyl groups from lysine residues on non-histone proteins. It has been observed that in lupus mouse models, specific HDAC6 inhibition reduces inflammation. Administration of pristane, a naturally …
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Computational and Pharmacological Characterization of HDAC6 Inhibition and Function
HDAC6 is a unique histone deacetylase. It contains two catalytic domains, of which they act independently or in tandem. It belongs to the class IIb HDACs and is Zn2+ dependant. It has been seen to be involved in various diseases such as diabetic neuropathies and certain cancers including breast …
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Hdac6 Inhibition Reverses Long-Term Doxorubicin-Induced Cognitive Dysfunction By Restoring Microglia Homeostasis
… barrier permeable histone deacetylase 6 (HDAC6) inhibitor successfully reverses long-term CICD following a therapeutic doxorubicin dosing schedule in female mice, as assessed by the puzzle box test and novel object/place recognition test. Long-term CICD was associated with a decreased …
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HDAC6 activity is required for efficient polarization and intracellular transport of organelles in directionally migrating cells
… non-histone substrates by histone deacetylase 6 (HDAC6) has been shown to affect chemotactic invasion (e.g., Haggarty et al., 2003; Hubbert et al., 2002; Tran et al., 2007) or wound healing motility (Lafarga et al., 2012) of fibroblasts. Chemotactic invasion and wound-healing motility are both …
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The Role of Histone Deacetylase 6 Inhibition on Systemic Lupus Erythematosus
… the use of current ones. Histone deacetylase 6 (HDAC6) plays a variety of biologic functions in a number of important molecular pathways in diverse immune cells. Both innate and adaptive immune cells contribute to pathogenesis of lupus. Among those cells, B cells play a central role in …
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Modulation of Histone Deacetylases Attenuates the Pathogenesis of Alzheimer's disease
… Beispiel für eine solche Lysin-Deacetylase ist HDAC6. Es ist bekannt, dass HDAC6 mit zytoplasmatischen Substraten wie α-Tubulin, einem Bestandteil von Mikrotubuli, und Hsp90, einem molekularen Chaperon, reagiert. Durch seine Wirkung auf α-Tubulin, hat sich gezeigt, dass HDAC6 an der negativen …
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Molecular mechanisms involved in the regulation of beta-cell viability by Signal Regulatory Protein-Alpha (SIRPα)
… it has been proposed that histone deacetylase 6 (HDAC6) binds to SIRPα, and that this binding interaction suppresses the STAT1 mediated pro-apoptotic pathway, thus protecting β-cells against death by apoptosis. It is not known how this interaction is regulated. In this study, the aim was to …
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The Regulation of Lipid Metabolism and Mitochondrial Quality Control in Health and Disease
… we find that loss of cytoplasmic deacetylase HDAC6 leads to aberrant accumulation of lipid in vitro and in vivo. HDAC6 knock-out (KO) mice gain more weight than WT counterparts after a high-fat diet regimen. Additionally, the intermediary metabolism of cells lacking HDAC6 is disrupted as they …
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Selective histone deacetlyase inhibition decreases disease in lupus-prone mice
Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that acetylates several proteins that are involved in the immune response. HDAC6 inhibition has been shown in various models to decrease inflammation by altering various proteins involved in the dysregulation of B and T cell responses. In our …
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An evaluation of cancer biomarkers in normal ovarian epithelial cells and ovarian cancer cell lines
… the following genes: HDAC1, HDAC2, HDCA3, HDAC5, HDAC6, HDAC7, HDAC8, LPAR1, LPAR2, MUC16 and FOSL1, against normal housekeeping genes GAPDH and HPRT. In addition, immunocytochemistry was also used in the validation process of the aforementioned genes. Significance: ovarian cancer cells express …
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Mechanisms Underlying The Heterogeneous Sensitivities of Cancer Cells to Proteasome Inhibitors
… investigation of a novel histone deacetylase 6 (HDAC6)-selective inhibitor suggested that the cytoprotective role of the cytoplasmic histone deacetylase 6 (HDAC6) in response to proteasome inhibition may have been previously overestimated.</p>
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Development Of Elisa-Based Hdac Activity Assay For Identification Of Isoform Selective Hdac Inhibitors
… C2-SAHA, and C3-Ethyl SAHA derivatives. A HDAC6-selective inhibitor has been identified from the SAHA derivatives, which showed similar selectivity compared to the known HDAC6 selective tubastatin. The combined screening data of the SAHA derivatives suggest that modification at the linker …
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The structural requirements of histone deacetylase (hdac) inhibitors: suberoylanilide hydroxamic acid (saha) analogues modified at c3, c6, and c7 positions enhance selectivity
… ethyl-substituted analogue showed preference for HDAC6 over HDAC1 and HDAC3 even though it displayed decreased potency. The C6-SAHA analogues displayed diverse selectivity; the C6-SAHA methyl variant displayed preference for class I, t-butyl variant showed a dual-HDAC1 and HDAC6 selectivity, and …
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Marine microbial co-cultivation and the production of novel bioactive secondary metabolites for drug discovery
… with activity against the disease biomarkers; HDAC6, EL and PPARα. A total of 14 metabolites were isolated and structures were elucidated, seven of which are new metabolites not previously described, with six from bioactive fractions. A notable discovery was that of a novel proline-rich peptide …
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Hijacking Cancer Signaling: First-in-class JPRK-targeting Ligands for Fibrolamellar Hepatocellular Carcinoma
… with onco-proteins, such asSTAT5B and HDAC6, were perturbed. Target engagement studies confirmed that the compounds were not only altering the protein-protein interaction with HDAC6, but also hampering its phosphorylation. To further probe how the compounds selectively trigger cell …
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Functional Genomics Based Interrogation of Cell-Fate Determination Pathways
… length by inhibiting the tubulin deacetylase HDAC6 (histone deacetylase 6) countered deviant pathway activities driven by Stk11 loss. My study demonstrates that Stk11 is a critical mediator in both the Hh and the Wnt pathways, and that functional genomics based approaches to dissecting …
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Characterisation of an acetylation-dependent FLIP/Ku70 complex that regulates FLIP expression
… Droxinostat (HDAC3, 6 and 8) and Tubacin (HDAC6), it was determined that HDAC6 is a key HDAC in regulating the acetylation of Ku70 and the expression of c-FLIP in colorectal cancer cells.<br/><br/> In summary, this study identified an interaction between the anti-apoptotic protein c- FLIP …
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The role of CD133 in mouse incisor tooth epithelium
… for the sequential recruitment of Arl13b and Hdac6 to the primary cilium regulating proper ciliogenesis. Establishment of an in vitro cell culture model of dental epithelial cells allowed the investigation of nuclear CD133 under normal physiological conditions. To date, nuclear CD133 has been …
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