Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"HDAC5"”.
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Defining the potential of HDAC5 and HDAC9 as therapeutic targets for Parkinson’s disease
… The targeted inhibition of Class IIa HDACs, HDAC5 and HDAC9 have demonstrated some positive preliminary findings in PD models. Therefore, this thesis aims to better understand the therapeutic potential of the inhibition of these HDACs in the PD context. To do this, we utilised both …
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The Role of Chromatin Remodeling in Hippocampus in Depression and Antidepressant Action
… a novel role for the histone deacetylase HDAC5 in the therapeutic efficacy of chronic imipramine after defeat stress. I found that chronic imipramine downregulates HDAC5 after stress, that HDAC5 overexpression in the hippocampus blocks the behavioral effects of imipramine in defeated mice, …
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Roles of HDACs and MEF2 in Adult Hippocampal Neurogenesis
… the Class I HDAC, HDAC3 and the Class IIa HDAC, HDAC5 as well as the Class IIa HDAC binding partner, myocyte enhancer factor 2 (MEF2). Using conditional knockout (cKO) mice and in vitro cell culture, I show that histone deacetylase 3 (HDAC3) is required for the proliferation of adult NSPCs. …
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Roles of Class II Histone Deacetylases in the Cardiovascular System
… elucidated. Here I show that in the absence of HDAC5, the heart becomes profoundly enlarged in response to calcineurin signaling and pressure overload. The cardiac phenotype of HDAC5 mutant mice is remarkably similar to that of HDAC9 mutant mice, strongly suggesting that these two HDACs play …
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Receptor-Mediated Hypertrophic Signaling Via Protein Kinase D and Histone Deacetylase 5 in Adult Myocytes
… of PKD and its functional role in regulation of HDAC5 translocation. HDAC5 is a transcriptional repressor whose dynamic shuttling between the nucleus and the cytosol determines the outcome of transcriptional control for MEF2-dependent genes. I use a combination of biochemical approach with …
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Preclinical evaluation of a novel AAV-GDF5 vector in a 6-OHDA model of Parkinson’s disease and evaluation of the effect of 6-OHDA on the expression of HDACs
… HDAC3, 5 and 9 expression in the rat brain. HDAC5 and HDAC9 are of particular interest to our group as our group has shown that their expression correlates with three markers of dopaminergic neurons in both the mouse and human substantia nigra. HDAC3 was also selected as an example of a …
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Effects of scriptaid on osteocytes skeletal homeostasis and metabolic functions
… of Ocy454-12H induced nuclear translocation of Hdac5 whereas it did not affect Hdac4. Silencing of Hdac5 expression with shRNA increased Sost basal expression and blocked Sost suppression induced by Scriptaid. However, Glut4 up-regulation by Scriptaid was independent of the HDAC4/5-MEF2C …
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ROLE OF G9A IN SKELETAL MYOGENESIS
… and enhances the interaction with co-repressor HDAC5. This occurs through blocking of calcium signalling-dependent phosphorylation and cytoplasmic export of HDAC5. Furthermore, we show that G9a over-expression in Drosophila melanogaster results in a perturbation of muscle function by …
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An evaluation of cancer biomarkers in normal ovarian epithelial cells and ovarian cancer cell lines
… of the following genes: HDAC1, HDAC2, HDCA3, HDAC5, HDAC6, HDAC7, HDAC8, LPAR1, LPAR2, MUC16 and FOSL1, against normal housekeeping genes GAPDH and HPRT. In addition, immunocytochemistry was also used in the validation process of the aforementioned genes. Significance: ovarian cancer cells …
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Nouvelles combinaisons thérapeutiques pour améliorer l'efficacité anti-tumorale de l'inhibition d'HDAC5
… mécanismes d’action de l’histone déacétylase 5 (HDAC5) dans les cellules cancéreuses. Nos résultats démontrent que l’inhibition sélective d’HDAC5 module l’expression de protéines du complexe I de la chaîne respiratoire mitochondriale, de protéines pro- et anti- oxydantes et des protéines …
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Proteomic Investigation of Interferon Alpha Stimulation and Viral Regulation to Identify Candidate Antiviral Restriction Factors
… temporal profiles of human and viral proteins. HDAC5 was found to be targeted for proteasomal degradation by the viral protein C6. Overexpression and knockdown of HDAC5 demonstrated its restriction of both VACV and herpes simplex virus-1 replication. Finally, both datasets were considered …
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Epigenetic Modification of Phenotype in Intestinal Smooth Muscle Cells
… phenotype, with increased levels of DNMT1 and HDAC5. Repeated passage human ISMC also had decreased expression of contractile markers SMA and SM22, mimicking the rat model. These findings suggest that the altered contractile phenotype of ISMC is associated with epigenetic changes, including …
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Regulation of Glut-4 Expression in Skeletal Muscle cells: The Roles of Nuclear Respiratory Factor-1 and calcium/calmodulin dependent protein Kinase
… respectively, were assessed by ChIP assay. HDAC5 nuclear export was assessed by immunocytochemistry and mRNA levels by qRT-PCR. Overexpression of NRF-1 resulted in ~3-fold increases in mef2a-bound NRF-1 and glut4 -bound MEF2A at 6 h and 8 h post Dox treatment, respectively. MEF2A and GLUT4 …
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Identification of novel protein kinase regulators of TGFβ signalling
… class IIa histone deacetylases (HDACs) HDAC4 and HDAC5. From the research conducted during this thesis project, it is now evident that SIKs also function to modulate TGFβ-dependent transcriptional responses. However, the precise molecular mechanisms underlying this observation remain to be …
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MOLECULAR DEFECTS OF MEF2 FAMILY PROTEINS AND NAC PROTEINS THAT BLOCK MYOGENESIS AND PROMOTE TUMORIGENESIS IN RHABDOMYOSARCOMA
… more strongly interacts with and recruits HDAC5 to myogenic gene promoters to repress muscle specific genes. Overexpression of the MEF2Cα2 isoform in RMS cells increases myogenic activity and promotes differentiation in RMS cells. We have also identified a serine protein kinase, SRPK3, …
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Characterisation of the molecular mechanisms of dopaminergic axonal growth and their impairment in Parkinson's disease
… BMP-Smad pathway, and here we demonstrate that HDAC5 nuclear localization or sequestration is central to the regulation of the BMP-Smad pathway. Finally, we demonstrate that GDNF, unlike GDF5, cannot activate its downstream transcriptional response in the presence of α-synuclein. Taken together, …