Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"HDAC3"”.
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Hdac3 is a Critical Regulator of Neural Crest Progenitor Cell Biology
… Class I histone deacetylases (Hdacs), including Hdac3, play critical roles in regulating gene transcription, through both epigenetic and non-epigenetic means. In this dissertation, I use mouse genetics to explore the previously undescribed role of Hdac3 in regulating neural crest progenitor cell …
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Epigenomic and Transcriptional Regulation of Hepatic Metabolism by REV-ERB and Hdac3
… genes. Here we show that histone deacetylase 3 (HDAC3) is recruited to the mouse liver genome in a circadian manner. Histone acetylation is inversely related to HDAC3 binding, and this rhythm is lost when HDAC3 is absent. Diurnal recruitment of HDAC3 corresponds to the expression pattern of …
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STUDY ON HISTONE DEACETYLASE 3 AND ITS PHARMACOLOGICAL REGULATION IN THE PATHOPHYSIOLOGY OF ADIPOSE TISSUE
… chemical inhibitors or genetic alterations of HDAC3 have shown metabolic rewiring of white adipocytes towards browning via the activation of a futile cycle of lipolysis and lipogenesis. Obesity is characterized by chronic low-grade inflammation due to secretion of pro-inflammatory cytokines by …
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X-Box Binding Protein-1 is Important in Maintenance of Endothelial Integrity and Migration
… of chromatin structure. In particular, HDAC3 is involved in maintaining endothelial integrity. HDAC3 and XBP1 are similarly expressed in the bifurcation regions of aorta. Unspliced XBP1 (XBPlu) is expressed in a similar manner in endothelial cells. In the present study we investigated …
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The Role of Class I Histone Deacetylases in Cardiovascular Development and Disease
… knockout alleles for HDAC1, HDAC2, and HDAC3. Through global and tissue specific analyses, we hope to identify specific roles of these enzymes in developmental, physiological, and pathological settings. Here I show that HDAC1 and HDAC2 act redundantly in controlling cardiac growth, …
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Valproic Acid Disrupts Hematopoiesis in Xenopus Laevis Through the Inhibition of Histone Deacetylase 3.
… HDAC inhibitor, valproic acid (VPA), to identify hdac3 as an essential mediator of primitive hematopoiesis. Exposure to VPA during gastrulation results in a marked and specific block of primitive hematopoiesis in Xenopus embryos. Furthermore, pharmacological and loss of function studies …
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Roles of HDACs and MEF2 in Adult Hippocampal Neurogenesis
… hippocampal neurogenesis: the Class I HDAC, HDAC3 and the Class IIa HDAC, HDAC5 as well as the Class IIa HDAC binding partner, myocyte enhancer factor 2 (MEF2). Using conditional knockout (cKO) mice and in vitro cell culture, I show that histone deacetylase 3 (HDAC3) is required for the …
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Preclinical evaluation of a novel AAV-GDF5 vector in a 6-OHDA model of Parkinson’s disease and evaluation of the effect of 6-OHDA on the expression of HDACs
… we examined how 6-OHDA administration affects HDAC3, 5 and 9 expression in the rat brain. HDAC5 and HDAC9 are of particular interest to our group as our group has shown that their expression correlates with three markers of dopaminergic neurons in both the mouse and human substantia nigra. …
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Autophagy: activation, function and regulation by a protein restricted diet during pregnancy and lactation
… decreases expression of histone deacetylase-3 (Hdac3) in the liver of rat dams. Histone acetylation is associated with increased gene transcription. Specifically, it has been reported that HDAC3 inhibition induces LC3B expression, a primary autophagy marker and lipid accumulation. More …
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The structural requirements of histone deacetylase (hdac) inhibitors: suberoylanilide hydroxamic acid (saha) analogues modified at c3, c6, and c7 positions enhance selectivity
… showed preference for HDAC6 over HDAC1 and HDAC3 even though it displayed decreased potency. The C6-SAHA analogues displayed diverse selectivity; the C6-SAHA methyl variant displayed preference for class I, t-butyl variant showed a dual-HDAC1 and HDAC6 selectivity, and 2-ethylhexyl variant …
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Caspase-dependent Signaling as an Inductive Cue for Cardiac Hypertrophy
… caspase cleavage targets histone deacetylase 3 (HDAC3) and gelsolin (GSN). HDAC3 cleavage was observed during early stages of hypertrophy and reduced in the presence of a caspase inhibitor. Caspase-mediated GSN cleavage occurred at latter stages, coincident with the cytoskeletal alterations that …
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EPIGENETIC REGULATION OF MICROGLIAL PHOSPHATIDYLINOSITOL 3-KINASE PATHWAY INVOLVED IN SYNAPTIC PLASTICITY IN RODENTS
… by miR-21-5p and histone modifications via HDAC3 resulting in changes in PI3K expression, the phosphorylation of AKT and the cAMP response element binding protein (CREB) and ultimately brain-derived neurotrophic factor (BDNF) expression, shown to be involved in neuronal LTP. Microglial PI3K …
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Ruolo dell'Enantiomero (R)-9-HSA nel controllo della proliferazione in una linea di Adenocarcinoma del Colon umano
… effect of (S)-9-HSA on HDAC1, HDAC2 and HDAC3 activity was less effective than that of the (R)-9-HSA in vitro, and the inhibitory activity of both the (R)- and the (S)-9-HSA isomer, was higher on HDAC1 compared to HDAC2 and HDAC3, thus demonstrating the stereospecific and selective …
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Molecular mechanisms of Kruppel-like Factor 4
… Cyclin B1, I demonstrate that KLF4 recruits HDAC3, decreasing histone acetylation. In addition, I show that KLF4 is acetylated by p300/CBP, and that acetylation of KLF is important in the activation of target genes as well as its ability to inhibit proliferation. I demonstrate that KLF4 …
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Characterization of Chronic Glucocorticoid Exposure on Natural Killer Cell Function: A Model for Stress Induced Alterations on the Epigenetic Landscape
… structure, and concomitant loss of HDAC1 and HDAC3 at regulatory loci. These results demonstrate chronic GC exposure to impact NK effector function through the modification of the epigenetic status of NK effector genes through HDAC redistribution and subsequent epigenetic changes in a promoter …
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An evaluation of cancer biomarkers in normal ovarian epithelial cells and ovarian cancer cell lines
… antibodies to the other six genes (HDAC1, HDAC2, HDAC3, HDAC7, HDAC8 and FOSL1) encoded proteins are underway. Conclusions: here we provide strong evidence suggesting that HDAC5, HDAC6, LPAR1, LPAR2, except MUC16 are up regulated in ovarian cancer. These data were confirmed by examining Human …
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Epigenetic modifications on WNT genes by dietary genistein during colon cancer development
… II. Nuclear level of histone deacetylase 3 (HDAC3) was enhanced by SPI and GEN. SPI and GEN suppressed the trimethylation of histone H3 Lysine 9 (H3K9Me3) and the phosphorylation of histone H3 Serine 10 (H3S10P). Methylation of the specific region of Sfrp2, Sfrp5, and Wnt5a genes was …
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Studien zur Expression von Klasse-1-Histon-Deacetylasen im humanen Endometrium sowie in Endometrium- und Mamma-Karzinomen
… in the stratum basale expressed HDAC1 and HDAC3 proteins. In the endometrial blood vessels a part of the endothelial cells and a part of the smooth muscle cells of the tunica media of the arteries and the arterioles were HDAC1 and 3 protein positive. A comparison of the endometrial HDAC1 …
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Role of Chaperonin CCT in G-protein Biosynthesis
… beta-, and gamma-tubulin), histone deacetylases (HDAC3, Set3p, and Hos2p), cell cycle regulators (Cdc20p, and Cdc55p), and proteins possessing the seven-bladed beta-propeller WD40 domain, including the beta-subunit of the heterotrimeric guanine nucleotide-binding protein (G-protein) complex (4, …
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Defining The Functions of Usp22 and Usp44 In Regulation of H2Bub1 Levels
… H2Bub levels. These data indicate that USP44 and HDAC3 work together within N-CoR, to repress transcription of target genes. Furthermore, USP44 expression is higher, and H2Bub1 levels are lower, in MDA-MB-231 triple negative breast cancer cells than in MCF-10A cells. Depletion of USP44 impairs …
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