Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"HDAC2"”.
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Grk3 Connects Angiogenesis and Neuroendocrine Differentiation In Prostate Cancer By Activating Hdac2 That Epigenetically Represses Tsp1 and Rest
… and NEPC. We found that histone deacetylase 2 (HDAC2) is one of the most upregulated epigenetic regulators in NE tumors compared to non-NE tumors patient prostate tumors. We also found that G-protein coupled receptor kinase 3 (GRK3) is a critical regulator of both angiogenesis and neuroendocrine …
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The Role of Class I Histone Deacetylases in Cardiovascular Development and Disease
… conditional knockout alleles for HDAC1, HDAC2, and HDAC3. Through global and tissue specific analyses, we hope to identify specific roles of these enzymes in developmental, physiological, and pathological settings. Here I show that HDAC1 and HDAC2 act redundantly in controlling cardiac …
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Inter-Organellar Nucleic Acid Communication by a Mitochondrial tRNA Regulates Nuclear Transcription
… interaction of NARS2 with histone deacetylase 2 (HDAC2) and repressed HDAC2 association with chromatin. Accordingly, inhibiting tRNA-dependent NARS2-HDAC2 complex formation licensed HDAC2 binding to target gene loci and elicited transcriptional silencing. Interfering with the …
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Postnatal Role for Histone Deacetylase 1 and 2 in Behavioral and Neuronal Homeostasis
… with recent attention focused on HDAC1 and HDAC2. The overlying goal of my Ph.D. thesis has been to further delineate how the loss of the HDAC1 and HDAC2 genes affects learning and memory and other complex behaviors. We accomplished this in three separate studies. First, we examined whether …
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Novel Mechanisms of Β-Adrenergic Signaling In Prostate Cancer Progression
… epigenetic regulation by histone deacetylases 2 (HDAC2) is necessary for stress to induce cardiac hypertrophy, its mechanism are unknown in cancer progression. Similarly, another regulator of β-adrenergic signaling, GRK3 was recently shown to be a new critical regulator of prostate cancer …
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Methyl-CpG-Binding domain proteins and histone deacetylases in the stage-specific differentiation of olfactory receptor neurons
… HDAC family members. Biochemically, HDAC1 and HDAC2 associate with repressor complexes recruited by both MBD2 and MeCP2. HDAC1 and HDAC2, however, are divergently expressed in the OE, a pattern that is recapitulated in the brain. Rather than simultaneous inclusion in a complex, therefore, the …
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Nitric oxide induces chromatin remodelling in the developing central nervous system
… S-nitrosylation of histone deacetylase 2 (HDAC2) decreases its affinity for chromatin, leading to increased histone acetylation levels. This NO-dependent regulation of HDAC2 promotes changes in endogenous gene expression and affects the dendritic length of cortical neurons.
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Psychosocial Distress Mediates Immune Dysregulation Through Alterations in Global Epigenetic Patterns and Chromatin Remodeling Proteins
… with increased nuclear localization of HDAC2, suggesting that GCs recruit HDAC2 into the nucleus causing decreased global H4-K8-Ac and NKCA. These data identify decreased global H4-K8-Ac and increased nuclear localization of HDAC2 as potential markers of decreased NK cell lytic activity …
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Ruolo dell'Enantiomero (R)-9-HSA nel controllo della proliferazione in una linea di Adenocarcinoma del Colon umano
… The inhibitory effect of (S)-9-HSA on HDAC1, HDAC2 and HDAC3 activity was less effective than that of the (R)-9-HSA in vitro, and the inhibitory activity of both the (R)- and the (S)-9-HSA isomer, was higher on HDAC1 compared to HDAC2 and HDAC3, thus demonstrating the stereospecific and …
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An evaluation of cancer biomarkers in normal ovarian epithelial cells and ovarian cancer cell lines
… expression levels of the following genes: HDAC1, HDAC2, HDCA3, HDAC5, HDAC6, HDAC7, HDAC8, LPAR1, LPAR2, MUC16 and FOSL1, against normal housekeeping genes GAPDH and HPRT. In addition, immunocytochemistry was also used in the validation process of the aforementioned genes. Significance: ovarian …
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Studies of the MYM-type zinc finger protein ZMYM3
… by each mutation in this cluster, including: HDAC2, a histone deacetylase, LSD1, a histone demethylase, CoREST, a co-repressor of transcription, TFII-I, a transcription factor, and ZMYM3, an MYM-type zinc finger protein of unknown function. By making several truncation mutants of ZMYM3, I show …
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Function and Regulation of Phosphatidylinositol 3,4,5-Triphosphate-Dependent Rac Exchanger 1 (P-Rex1) in Cancer
… inhibitors or silence of endogenous HDAC1 and HDAC2 markedly elevated P-Rex1 transcription in non-metastatic prostate cancer cells, whereas overexpression of recombinant HDAC1 in metastatic prostate cancer cells suppressed P-Rex1 expression. HDAC inhibitor trichostatin A (TSA) also …
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Epigenetic Modification of Phenotype in Intestinal Smooth Muscle Cells
… 1 (DNMT1) and histone deacetylase 2 (HDAC2) expression. ISMC from human strictures showed a decreased contractile phenotype, with increased levels of DNMT1 and HDAC5. Repeated passage human ISMC also had decreased expression of contractile markers SMA and SM22, mimicking the rat model. …
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MOLECULAR STUDY OF CHROMATINOPATHIES: THE CASE OF RUBINSTEIN-TAYBI AND RETT SYNDROMES
… three RTT-like patients unreported variants in HDAC2, and NBEA, DYNC1H1 and SLC35F1 genes respectively, whose role is currently under investigation through in vitro models. Conclusions: The study on microbiota composition could pave the way for novel therapeutic interventions for RSTS, while the …
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Purification and Characterization of a Methyl-DNA Binding Protein Complex from Primary Erythroid Cells
… were identified in the sample: MBD2, RbAp48, HDAC2 and MTA1. Another identified protein, MENT, is a factor expressed only in chicken hematopoietic cells. These five proteins, as well as the MeCPl component Mi2, were found to tightly coelute by Western blotting of gel-filtration fractions from …
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Characterization of Chronic Glucocorticoid Exposure on Natural Killer Cell Function: A Model for Stress Induced Alterations on the Epigenetic Landscape
… related to recruitment of histone deacetylase 2 (HDAC2) with concomitant reduction in H3K9-acetylation (Ac). In contrast, IL-6 and IFN-g were primed for increased transcription upon cellular activation demonstrating increased H4K8Ac, increased accessibility of the chromatin structure, and …
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MeCP2 and the Epigenetic Regulation of Excitatory Synaptic Transmission
… MeCP2. After acute knockdown of HDAC1 or HDAC2, we found deficits in excitatory synaptic transmission that mimicked the defects seen after the constitutive loss of MeCP2. In summary, we have discovered a role for the transcriptional repressor, MeCP2, and two components of its repressor …
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Regulation of mammalian SINE transcription
… SINEs were also shown to be occupied by HDAC1, HDAC2 and a component of SWI/SNF complex, Brahma. Human Alus were also found to be occupied by components of two corepressor complexes, SIN3 and NuRD. Whether MBD proteins repress SINE transcription in a DNA methylation-dependent manner was further …
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Functional characterization of CDY family proteins and their role in recognition of the heterochromatic histone H3K9me3 modification
… die Interaktion mit Histonedeacetylasen (HDAC1, HDAC2) oder dem Repressorkomplex CoREST erreicht wird. Interessanterweise konnte in der vorliegenden Doktorarbeit ein weiterer Interaktionspartner von CDYL1 identifiziert werden: PRMT5. PRMT5 ist eine Argininmethyltransferase und in vitro …
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The role of retinoic acid in glioma growth control
… NCOA1, NCOA2, transcriptional co-repressor genes HDAC2, NCOR1, and NRPI1 are all significantly lower in high grade glioma with an increase in the expression of transcriptional repressor HDAC1. There is also significantly reduced expression of CYP26B1, involved in the metabolism of RA. Together, …