Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"HDAC1"”.
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REGULATION OF NEURAL CREST DEVELOPMENT REQUIRES FUNCTIONAL INTERACTIONS BETWEEN HDAC1, TFAP2A AND FOXD3
… in the NCCD process. Among them, zebrafish hdac1, foxd3 and tfap2a are necessary for the specification and development of neural crest sublineages. In our study, we have shown that hdac1 is required for the differentiation of enteric, DRG and sympathetic neurons. Further, in hdac1b382 …
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Understanding C/EBPbeta LAP/LIP Transcriptional and Adipogenic Potential Through Regulation by HDAC1 and GCN5
… GCN5/PCAF and the deacetylase complex mSin3A/HDAC1 regulate C/EBPβ activity on the C/EBPa promoter. GCN5/PCAF-mediated acetylation of C/EBPβ was shown to positively affect its transcriptional activity in a steroid-dependent mechanism via the glucocorticoid receptor (GR). GR relieves HDAC1 …
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Untersuchungen zur Assoziation des transkriptionellen Repressors Snail aus Drosophila melanogaster mit den Korepressoren CtBP und HDAC1
… konnte die Assoziation von Snail mit CtBP oder HDAC1 gezeigt werden. Ein für die vorliegende Arbeit in Kaninchen etablierter anti-Snail Antikörper immunopräzipitierte einen nativen Snail-HDAC1-Komplex aus Kernextrakt, der kein CtBP enthält. Diese Experimente deuten an, dass Snail zwei …
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Regulation of neuronal genomic integrity through histone deacetylase cooperativity
… functions of two lysine deacetylases, SIRT1 and HDAC1, in the neuronal response to DNA double strand breaks (DSBs). Both SIRT1 and HDAC1 were previously shown to promote neuronal survival in a mouse model of neurodegeneration in which the appearance of DSBs precedes other neurotoxic symptoms. …
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Histone Deacetylase 1: Mutagenesis And Small Molecule Studies
<p>Histone deacetylase 1 (HDAC1) has been linked to cell growth and cell cycle regulation, which makes it a widely recognized target for anticancer drugs. The 14 Å channel of Class 1 HDAC isotypes has long being hypothesized to be the exit cavity for acetate following deacetylation. The amino acids …
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Ruolo dell'Enantiomero (R)-9-HSA nel controllo della proliferazione in una linea di Adenocarcinoma del Colon umano
… by inhibiting histone deacetylase 1 (HDAC1) activity, showing interesting features as a new anticancer drug. The interaction of 9-HSA with the catalytic site of the 3D model has been tested with a docking procedure: noticeably, when interacting with the site, the (R)-9-enantiomer is …
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Postnatal Role for Histone Deacetylase 1 and 2 in Behavioral and Neuronal Homeostasis
… diseases with recent attention focused on HDAC1 and HDAC2. The overlying goal of my Ph.D. thesis has been to further delineate how the loss of the HDAC1 and HDAC2 genes affects learning and memory and other complex behaviors. We accomplished this in three separate studies. First, we …
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The Role of Class I Histone Deacetylases in Cardiovascular Development and Disease
… we generated conditional knockout alleles for HDAC1, HDAC2, and HDAC3. Through global and tissue specific analyses, we hope to identify specific roles of these enzymes in developmental, physiological, and pathological settings. Here I show that HDAC1 and HDAC2 act redundantly in controlling …
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The Role of Cyp33 in MLL Mediated Gene Repression
… of MLL and increases Histone Deacacetylase1 (HDAC1) to the repression domain (RD) of MLL thereby reducing target gene expression (Xia, Z 2003, Fair, K 2001, Anderson, M 2002). It has been hypothesized that cis-trans prolyl isomerase activity is important for recruitment of HDAC1 as increased …
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Early liver formation in zebrafish: a molecular and morphological approach
… a novel allele of histone deacetylase 1 (hdac1), which plays distinct roles in endodermal organogenesis in zebrafish. Loss of Hdac1 causes defects in timely liver specification and subsequent differentiation, while mosaic analyses revealed a cell-autonomous role for Hdac1 in the endoderm …
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A study of the composition and function of telomeric chromatin in drosophila melanogaster.
… (ChIP) I was able to identify three proteins, HDAC1, SU(VAR)3-9, and HP1c, as integral components of telomeric heterochromatin in Drosophila. HDAC1 and SU(VAR)3-9 are both believed to be involved in the gene-silencing process, and thus, their presence at telomeres could explain the phenomenon …
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Maintenance of Genomic Integrity by RSF1 Chromatin Remodeler
… condensation 48 G. RSF1 directly interacts with HDAC1 but, not HP1α during mitosis 50 H. RSF1 plays a crucial role in HDAC1 deposition at the mitotic chromosome arms 53 I. Knockdown of RSF1 causes defects in sister-chromatid cohesion and kinetochore protein assembly 56 J. C-terminal of RSF1 …
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Methyl-CpG-Binding domain proteins and histone deacetylases in the stage-specific differentiation of olfactory receptor neurons
… MBD and HDAC family members. Biochemically, HDAC1 and HDAC2 associate with repressor complexes recruited by both MBD2 and MeCP2. HDAC1 and HDAC2, however, are divergently expressed in the OE, a pattern that is recapitulated in the brain. Rather than simultaneous inclusion in a complex, …
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Molekulare Mechanismen der antiinflammatorischen und immunsuppressiven Effekte von Interleukin-10
… ICSBP und die Histon-Deacetylase HDAC1 durch IL-10 posttranslational durch Phosphorylierung modifiziert werden. Für HDAC1 konnte eine Rolle bei der Vermittlung des immunsuppressiven Effektes von IL-10 auf das für die Antigenpräsentation essentielle MHCII-Molekül HLA-DR nachgewiesen …
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Function and Regulation of Phosphatidylinositol 3,4,5-Triphosphate-Dependent Rac Exchanger 1 (P-Rex1) in Cancer
… (HDAC) inhibitors or silence of endogenous HDAC1 and HDAC2 markedly elevated P-Rex1 transcription in non-metastatic prostate cancer cells, whereas overexpression of recombinant HDAC1 in metastatic prostate cancer cells suppressed P-Rex1 expression. HDAC inhibitor trichostatin A (TSA) also …
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MECHANISM OF TRANSCRIPTIONAL REPRESSION OF MMP-9 BY INTERFERON-β
… (TSA). ChIP analysis shows that IFN-beta induced HDAC1 recruitment to the MMP-9 promoter is lost when the AP-1 binding site is inactivated by a point mutation. Altogether, these results establish that the repression of MMP-9 transcription in response to IFN-beta occurs by the recruitment of HDAC1 …
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The structural requirements of histone deacetylase (hdac) inhibitors: suberoylanilide hydroxamic acid (saha) analogues modified at c3, c6, and c7 positions enhance selectivity
… analogue showed preference for HDAC6 over HDAC1 and HDAC3 even though it displayed decreased potency. The C6-SAHA analogues displayed diverse selectivity; the C6-SAHA methyl variant displayed preference for class I, t-butyl variant showed a dual-HDAC1 and HDAC6 selectivity, and 2-ethylhexyl …
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Colocalization between Akirin, the NuRD Complex, and Histone Modifications
… subunits of the NuRD complex. The NuRD subunit, HDAC1, functions to remove acetyl groups from histone tails. Therefore, the colocalization between Akirin and histones modified by acetylation and methylation were also examined.</p> <p>A novel polytene squash method was developed as a byproduct of …
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Developing a novel Drosophila model to study Menin biological function
… blastoderm stage onwards. Colocalisation with HDAC1 was observed in both contexts, consistent with the conserved mammalian Menin-HDAC1 association. Biochemical characterisation demonstrated that HA-tagged Menin can be immunoprecipitated from dissected larval brain and adult head lysates. …
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MeCP2 and the Epigenetic Regulation of Excitatory Synaptic Transmission
… (HDACs) 1 and 2 from mature hippocampal neurons. HDAC1 and 2 are present in the transcriptional repressor complex containing MeCP2. After acute knockdown of HDAC1 or HDAC2, we found deficits in excitatory synaptic transmission that mimicked the defects seen after the constitutive loss of MeCP2. In …
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