Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 173 for “"HCV"”.
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HCV Resistenztestung
… Arbeit. Aufgrund der Häufigkeitsverteilung der HCV-Genotypen in Deutschland wurde die Entwicklung einer Resistenztestungsmethode auf die Genotypen 1b, 1a und 3a eingegrenzt. Im Fokus dieser Arbeit standen die NS3-, NS5A- und NS5B-Regionen. An diesen Regionen greifen die DAAs in den …
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Protection from HCV infection – Identification of mechanisms of resistance to HCV infection in exposed uninfected injection drug users.
Hepatitis C virus (HCV) is a leading cause of chronic liver disease. In the developed world, injection drug use (IDU) through sharing of infected needles and other paraphernalia remains the principal risk factor for HCV transmission. Effective but expensive treatment is now possible but there …
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Progress Towards Integrated Models of HCV Dynamics
… hepatitis C. One of the salient features of HCV is a complex regulatory scheme involving numerous viral and cellular components and which may be the key to its striking success in initiating and maintaining decades-long chronic disease in infected individuals. Lacking any known latent or …
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Characterizing B Cell Phenotype During Chronic HCV Infection
Chronic hepatitis C virus (HCV) infection is characterized by an attenuation of virus-specific T cell responses. The mechanisms leading to T cell attenuation are still not well understood, and likely involve several integrating correlates. We hypothesized that dysfunctions of antigen presenting …
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Defining the mechanism(s) of Hepatitis C virus (HCV) entry
Hepatitis C virus (HCV) is a major human pathogen and the leading cause of cirrhosis and liver cancer worldwide. HCV entry is clathrin- and pH-dependent, and requires CD81, Scavenger receptor BI (SR-BI), and the tight junction (TJ) proteins Claudin-1 and Occludin. Primary HCV strains cannot be …
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HCV Core Protein affects Lipid Metabolism in a Genotype-Dependent Manner
Chronic HCV infection is the leading cause of steatosis (fatty liver disease) and hepatocellular carcinoma (HCC). The virus establishes a chronic infection in 70% of patients and infects approximately 71 million people worldwide. Genotypes (gt) 1 and 3 are the most prevalent, with gt3 HCV being …
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Role of simple biomarkers in predicting fibrosis progression in HCV infection
… of fibrosis in chronic Hepatitis C hepatitis (HCV). There is little information whether they are useful longitudinal predictors of changes of fibrosis stage; i.e., progression of fibrosis to cirrhosis. The aim of the study is to examine the accuracy of biomarker panels AST to Platelet Ration …
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HCV Core Protein affects Lipid Metabolism in a Genotype-Dependent Manner
Chronic HCV infection is the leading cause of steatosis (fatty liver disease) and hepatocellular carcinoma (HCC). The virus establishes a chronic infection in 70% of patients and infects approximately 71 million people worldwide. Genotypes (gt) 1 and 3 are the most prevalent, with gt3 HCV being …
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Evaluation of HIV/HCV Prevention Intervention: Taking it to Treatment Court
… and Human Performances Evaluation of an HIV and HCV Prevention Intervention: Taking it to Treatment Court Chairperson: Annie Sondag The purpose of this study was to evaluate the HIV/HCV prevention intervention, Taking it to Treatment Court (TITTC), which is part of the greater Yellowstone County …
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Evaluation of HIV/HCV Prevention Intervention: Taking it to Treatment Court
… and Human Performances Evaluation of an HIV and HCV Prevention Intervention: Taking it to Treatment Court Chairperson: Annie Sondag The purpose of this study was to evaluate the HIV/HCV prevention intervention, Taking it to Treatment Court (TITTC), which is part of the greater Yellowstone County …
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Genetic Variations in Interferon-Induced Genes and HCV Recurrence after Liver Transplantation
Hepatitis C Virus (HCV) infection represents a worldwide pandemic and is currently the leading cause of cirrhosis and liver transplantation. After transplantation recurrence is almost universal with 96% of patients testing positive for viral RNA and exhibiting histological evidence of infection …
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Dendritic Cells Mediate the Dual Effects of IFN alpha/beta in HCV Immunity
<p>Hepatitis C virus (HCV) infects an estimated 170 million people and is responsible for considerable morbidity and mortality worldwide. Successful resolution of infection is achieved naturally in approximately 30% of infected individuals and correlates with a strong T cell response. Furthermore, …
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Role of Macrophage Subsets in CD8+ T Cell Dysfunction in Chronic HCV Infection
Chronic HCV infection causes generalized CD8+T cell impairment, not limited to HCV-specific CD8+ T cells. Infiltrating monocyte-derived macrophages contribute to a micro- environment that could impact CD8+T cells trafficking through the liver. Macrophages can differentiate into pro-inflammatory …
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Natural Products Chemistry of Leads Acting on MRSA, HCV, Malaria, and Depression Disorders
… serious threats to humans is hepatitis C virus (HCV) infections affecting approximately 4 million individuals in the United States, and 200-300 million individuals worldwide, causing over 8,000 deaths each year. HCV can progress to severe liver disorders such as fibrosis, cirrhosis, and …
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T-cell Dysfunction by HCV Core Protein Involves PD-1/PD-L1 Signaling.
… The role, if any, that PD-1/PDL-1 has in HCV infection is unknown. In this study we report that PD-1 is upregulated in T-cells from persons with chronic HCV infection when compared to healthy donors. In addition, PD-1 and PDL-1 are upregulated on T-cells from healthy donors when exposed to …
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Candidate Bivalent HCV Vaccine: A Novel Approach To Vaccine Design for Hyper-variable Viruses
… chronically infected with the hepatitis C Virus (HCV), and it estimated nearly 500,000 HCV related deaths will occur in 2020. Despite remarkable progress in treatment, the high number of occult infections, risk of reinfection following treatment, and the nearly 2 million new cases annually …
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Expression and function of osteopontin variants in HCV-related liver disease and hepatocellular carcinoma.
… in the pre-cancerous hepatitis C virus (HCV) infected liver. In this thesis we show that OPN is expressed in the liver and in HCC as three variants, the full-length protein OPN-A and two splice variants OPN-B and OPN-C. Through production of stable Huh-7 cells expressing the OPN variants, …
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Differences in miR-122 and miR-191 Expression in HBV- versus HCV-associated Hepatocellular Carcinoma
… evidence suggests miR-122 may be preserved in HCV-associated hepatocellular carcinoma (HCC). The goal of this thesis is to assess miR-122 and miR-191 expression levels in HBV- and HCV-associated HCC, the related non-tumor tissue, and normal liver tissue. Relative quantification of miR-122 and …
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