Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"HCN channels"”.
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NOVEL THERAPEUTIC APPROACHES EMERGING FROM HCN CHANNELS STRUCTURAL AND FUNCTIONAL STUDIES
… cyclic-nucleotide gated 1 (HCN1) channels are the molecular determinants of the cationic Ih current that regulates spontaneous electrical activity and synaptic integration in neurons. Mutations in the HCN1 gene have been linked to Early Infantile Epileptic Encephalopathy …
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SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOACTIVE MOLECULES LINKED TO PHOTOREMOVABLE PROTECTING GROUPS FOR SPATIO-TEMPORAL CONTROL OF THEIR ACTIVITY THROUGH PHOTOACTIVATION
… cyclic nucleotide-gated (HCN) channels. Ivabradine is a clinically used bradycardic agent indicated for the treatment of stable angina pectoris. Its mechanism of action involves antagonism of the HCN4 channel; however, the drug itself is unable to discriminate between the …
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AMPK-MEDIATED LONG-TERM REGULATION OF HCN4CONTRIBUTES TO AGE-RELATED SINUS BRADYCARDIA
… cyclic nucleotide-gated (HCN) channels mediates inward depolarizing currents, called If in the heart and Ih in the brain, that contribute to the regulation of neuronal excitability and cardiac rhythm. Among the HCN isotypes, HCN4 stands out for its prominent role in …
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Modulation of Hypoglossal Motoneurons by Nitric Oxide
… cyclic nucleotide gated (HCN) channels. These results suggest that sleep-induced nitrergic innervation of the HMN helps compensate for respiratory motoneuron disfacilitation and disruption of NO/cGMP signaling may contribute to the etiology of OSA. Although a causal link …
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Travelling waves modulated by resonant currents in laterally-inhibited grids of leaky integrate-and-fire neurons
… investigates the role of slow voltage-gated ion channels in modulating the dynamics of travelling waves, using a laterally inhibited spiking network of leaky integrate-and-fire neurons to link the single-neuron and network scales explicitly. Voltage-gated ion channels such as HCN channels that …
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Exploring the molecular mechanisms of AMPK-dependent regulation of neuroexcitability
… homeostasis, such as receptors, and ion channels, thus modulating cellular functions in a cell-specific manner. This thesis aimed to examine the effect of AMPK activation on two distinct ion channels: human TWIK-related acid-sensitive potassium (hTASK-3) channels and murine …
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Targeting Ion Channels to Distal Dendrites
… axons contain a high density of voltage-gated channels, presynaptic boutons house the machinery for synaptic vesicle-mediated neurotransmitter release, while dendrites contain ligand-gated and voltage-gated ion channels that generate and integrate postsynaptic responses. These primary …
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GPCR to Channel Communication in a Membrane Signaling Pathway
… cyclic nucleotide–gated (HCN) channels, resulting in an accelerated heart rate. In contrast, activation of M2 muscarinic receptors (M2Rs) and the inhibitory G protein (Gαi) opens G protein-gated inward rectifier K⁺ (GIRK) channels, slowing the heart rate. In addition to the …