Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"HCN channel"”.
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Skilled Behaviour and Bilateral Motor Map Expression
… electrical kindling as well as pharmacological HCN channel blocker ZD7288. Inactivating the cortex ipsilateral to the skilled forelimb completely eliminated ipsilateral and bilateral movement, indicating its role in bilateral movement representations.
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Investigating Experience-Dependent Plasticity in the Accessory Olfactory Bulb
… increased intrinsic excitability and decreased HCN channel-mediated IH currents. Consistent with increased inhibition by IGCs, MCs responded to sensory input stimulation with decreased depolarization and spiking following resident-intruder encounters. Different populations of IGCs are activated …
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Exploring the molecular mechanisms of AMPK-dependent regulation of neuroexcitability
… homeostasis, such as receptors, and ion channels, thus modulating cellular functions in a cell-specific manner. This thesis aimed to examine the effect of AMPK activation on two distinct ion channels: human TWIK-related acid-sensitive potassium (hTASK-3) channels and murine …
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The sophisticated architecture of the rat atrioventricular node
… of this region. The cardiac voltage-gated Na+ channel isoform (Na1.5) is known to play a major role in the generation and conduction of the action potential in the heart. Recently, various mutations of Na, 1.5 responsible for AV conduction block and Na,, 1.5+/- mice with impaired AV conduction …
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NOVEL THERAPEUTIC APPROACHES EMERGING FROM HCN CHANNELS STRUCTURAL AND FUNCTIONAL STUDIES
… cyclic-nucleotide gated 1 (HCN1) channels are the molecular determinants of the cationic Ih current that regulates spontaneous electrical activity and synaptic integration in neurons. Mutations in the HCN1 gene have been linked to Early Infantile Epileptic Encephalopathy …