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Showing 1 to 20 of 55 for “"HCMV"”.
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Detection of HCMV viral IL-10 (vIL-10) in healthy blood donors
<p>Human cytomegalovirus (HCMV) is widespread in the general population and can establish lifelong latency with expression of a limited subset of viral genes. The UL111A gene is expressed during both lytic and latent infection, and at least two protein isoforms are produced. During lytic infection, …
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CHARACTERIZATION OF HCMV-ENCODED CHEMOKINE RECEPTOR US28 TRANSDUCED MSU1.1 HUMAN FIBROBLAST CELLS
<p>Human Cytomegalovirus (HCMV) encodes the G-protein coupled receptor US28. Using a mouse model system, US28 was previously found to be oncomodulatory, increasing proliferation, inducing anchorage independent growth and loss of contact inhibition. Similarly, in the human glioblastoma cell line …
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THE HCMV INTERACTOME: A QUANTITATIVE ANALYSIS OF HUMAN CYTOMEGALOVIRUS-HOST PROTEIN INTERACTIONS
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that infects the majority of the adult population. Similarly to other herpesvirus, it is able to enter a state of latency, persisting within the host for life. Infection of healthy individuals is normally asymptomatic, however it is among the …
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HCMV Promotes Breast Cancer Metastasis: Impacts of CMVIL-10 in the Tumor Microenvironment
<p>Human cytomegalovirus (HCMV) is a highly species-specific, common human pathogen. While a large majority of people are infected with HCMV worldwide, infection is typically asymptomatic in immune competent individuals. To enhance virus persistence and avoid immune detection by the host, HCMV …
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Sequenzvariation des HCMV Glykoprotein B Gens durch Rekombination in vitro und in vivo
Das HCMV gB-Gen zeigt Sequenzvariationen auf, welche die Einteilung in vier verschiedene Genotypen ermöglichen. <br>Virusstämme verschiedenen Genotyps zeigen Unterschiede im Zelltropismus und im klinischen Verlauf einer HCMV-Infektion. <br>Zunächst wurde in der vorliegenden Arbeit untersucht, ob …
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IDENTIFICATION OF HCMV UL97 IN GBM CELL LINES AND A POSSIBLE ROLE FOR GANCICLOVIR
… gliomas. Recently, active Human Cytomegalovirus (HCMV) was identified in GBM cells, and has been a topic of debate concerning its role with tumor progression. This study used three established GBM cell lines; T98, LN229, and U87 in order to identify and examine the presence of HCMV …
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Detecting and defining immunity to human cytomegalovirus (HCMV) in health; combining QuantiFERON®-CMV and flow cytometry
Human cytomegalovirus (CMV) is an archaic and ubiquitous member of the beta-herpesvirus family (Herpesviridae), infecting approx. 83% of adults worldwide. Once infection has resolved, CMV enters a life-long latent state, with potential to reactivate. Infection is usually asymptomatic in healthy …
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Analysis of human cytomegalovirus in the healthy human carrier
… site of persistence of Human Cytomegalovirus (HCMV) in healthy carriers. However, the exact population of peripheral blood cells that carry HCMV and to what extent they express HCMV gene products in not known. I have examined the sites of HCMV persistence in the peripheral blood of healthy …
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Regulation of the HCMV UL98 Promoter by Cooperation of the Cyclic AMP Response Element and Gamma Interferon Response Element
<p>The HCMV UL98 early alkaline exonuclease gene promoter was examined to determine the DNA sequences as well as viral and/or cellular proteins functional in the regulation of this early gene. To assess promoter activation, UL98 promoter sequences were first cloned upstream of the chloramphenicol …
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Natural Killer Cell Responses to Human Cytomegalovirus
Human cytomegalovirus (HCMV), a member of the beta-herpesvirus family, establishes latent infection in the face of robust humoral and cell-mediated immune responses. In spite of significant efforts, the mechanisms implicated in protective immunity during HCMV infection are still not fully …
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Characterisation of Novel Secreted Antiviral Factors to Human Cytomegalovirus
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that infects a majority of the human population. Like other herpesviruses, HCMV readily establishes a latent infection that persists for the lifetime of the host and undergoes periodic lytic reactivation events. In healthy individuals, HCMV …
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The CD4⁺ T Cell Response to Human Cytomegalovirus
Human cytomegalovirus (HCMV) is a betaherpesvirus that infects most humans worldwide. In the healthy host, it elicits a broad immune response involving both the innate and adaptive arms of immunity, which is able to limit viral replication and prevent end-organ disease. However, like all …
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Investigating and exploiting the latency-associated expression of the human cytomegalovirus gene US28 in early myeloid lineage cells.
Human cytomegalovirus (HCMV) is a betaherpesvirus which establishes a lifelong persistent infection, underpinned by its ability to establish latent infection in early myeloid lineage cells, in the infected host. Although well controlled by a healthy immune system, HCMV causes pathological and life …
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Characterisation of Novel Autophagy and Necroptosis Antagonists Encoded by Human Cytomegalovirus
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that causes significant morbidity and mortality in immunocompromised individuals. To support its intracellular survival, HCMV has evolved diverse strategies to manipulate key host pathways and evade intrinsic immune defences. In this thesis, …
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Role of the Human Cytomegalovirus IE2 Protein on Transcriptional Regulation of Viral Promoters
<p>Human cytomegalovirus (HCMV) is a ubiquitous pathogen able to cause severe mortality and morbidity in immuno-compromised individuals. Successful infection by HCMV is dependent on expression of viral genes essential for replication. Immediate early (IE) gene products are the first subset of viral …
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Investigating the Role of Viral Long Non-Coding RNAs During Human Cytomegalovirus Latency
Human Cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. Primary infection with HCMV in healthy individuals is generally asymptomatic but the virus is never cleared and can go on to establish lifelong latency in cells of the early myeloid lineage. During latency, the virus reduces its gene …
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Functional and Mechanistic Analysis of Protein Degradation by Human Cytomegalovirus to Uncover Viral Immune Evasion Mechanisms
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that represents a significant global health burden. In immunocompetent individuals, HCMV establishes a lifelong persistent and typically asymptomatic infection that is controlled by a multifaceted host immune response. However, …
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Identification and Characterisation of Human Cytomegalovirus-Mediated Degradation of Helicase-Like Transcription Factor
… for early degradation by human cytomegalovirus (HCMV), the lab developed orthogonal screens using high resolution multiplexed mass spectrometry. Taking advantage of broad and selective proteasome and lysosome inhibitors, proteasomal degradation was found to be heavily exploited by HCMV. Several …
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The effect of human cytomegalovirus on neutrophil survival, autophagy, and extracellular traps
… effector functions. Human cytomegalovirus (HCMV) is a clinically important pathogen that infects the majority of the human population. Monocytes are considered the main vehicle of HCMV dissemination throughout the body, but little research has been done on its interaction with neutrophils. …
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Functional Characterisation of Protein Degradation during Human Cytomegalovirus Infection
Human cytomegalovirus (HCMV) is a ubiquitous and clinically significant herpesvirus, causing substantial morbidity and mortality in immunocompromised individuals and congenital infection in up to 1/100 pregnancies. HCMV has evolved a myriad of strategies to evade the host immune response, including …
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