Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 166 for “"HCC"”.
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위계적 질환군(HCC) 위험조정모델 기반 의료비용 예측
… 있다. 본 연구에서는 건강보험 표본코호트를 활용하여 미국 메디케어의 위계적 질환군 (HCC, Hierarchical Condition Category) 위험조정모델을 기초로 한국의 투약자료와 이전 의료이용 변수를 추가한 위험모델을 구축하고, 의료비용을 예측하고자 한다. 연구방법 건강보험공단에서 구축한 표본코호트 DB 2009년 자료를 이용하여 회귀모델을 구축하고, 변수별 회귀계수를 산출하였다. 2010년 자료를 바탕으로 2011년 개인별 의료비용을 예측하고, 2011년 실제 의료비용과 비교하였다. 의료비용 예측을 위해 4개의 …
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IDENTIFYING EARLY STEPS IN THE DEVELOPMENT OF HBV ASSOCIATED HCC
… half of the cases of hepatocellular carcinoma (HCC) and contributes to over 650,000 deaths per year making HCC is the fifth most common and second most deadly form of cancer.1-3 Many genes deregulated by the hepatitis B x-antigen (HBx), the oncogenic protein encoded by HBV, are known drivers of …
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CHARACTERIZATION OF HEPATITIS B VIRUS (HBV) IN HEPATOCELLULAR CARCINOMA (HCC) PATIENTS
… associated with hepatocellular-carcinoma (HCC) but its role in HCC remains poorly understood due to technological limitations. Here, we systematically characterize HBV in HCC patients. HBV sequences were enriched from 48 HCC patients using an oligo-bead-based strategy, pooled together and …
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Identification of DNA Copy Number-Dependent Transcriptional Deregulation inHepatocellular Carcinoma (HCC)
… expression profiles of hepatocellular carcinoma (HCC) was performed. By comparing DNA copy numbers in HCC subtypes, which have been previously defined based on gene expression pattern, it was found that the HCC subtype showing aggressive phenotype without expressing stemness-related genes had DNA …
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Investigating the Heterogeneity of Tumor Associated Macrophages in Human Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a liver cancer and is one of the leading causes of cancer death worldwide. Despite significant efforts in treating HCC, such as with the use of novel immune checkpoint inhibitors, the overall response rate remains low. This may be partly attributed to the lack of a …
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Patients with severe cutaneous adverse drug reactions have extremely high hair cortisol concentrations that do not correlate with presence of depression.
Background: Hair cortisol concentrations (HCC) +/- DHEA, a depression and stress biomarker has not been studied in severe cutaneous adverse drug reactions (SCAR). Objective: To determine DHEA/HCC correlation with SCAR-associated depression and compare the ratio with published values. Methods: …
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Patients with severe cutaneous adverse drug reactions have extremely high hair cortisol concentrations that do not correlate with presence of depression.
Background: Hair cortisol concentrations (HCC) +/- DHEA, a depression and stress biomarker has not been studied in severe cutaneous adverse drug reactions (SCAR). Objective: To determine DHEA/HCC correlation with SCAR-associated depression and compare the ratio with published values. Methods: …
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Zusammenhänge zwischen sozioökonomischen und anthropometrischen Daten und der Cortisolkonzentration im Haar gesunder Kinder
Hair cortisol concentrations (HCC) have been found to be related to various common childhood diseases, like otitis media, conjunctivitis, respiratory viral infections, and moreover asthma. However, the confounding effects of age, gender, body mass index (BMI), pubertal stage (Tanner stages), …
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Analisi integrata dell'espressione di geni/microrna in un modello di epatocancerogenesi sperimentale
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world, accounting for an estimated half million deaths annually, and represents one of the major health problems. Although much is known about the cellular changes that lead to HCC, the molecular pathogenesis of HCC is not yet …
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pH Regulatory Molecules In The Tumour Microenvironment: Modulators Of Aggressiveness And Immune Profile Of Human Hepatocellular Carcinoma
<b>Background:</b> Hepatocellular carcinoma (HCC) arises in an inflammatory, hypoxic/acidic microenvironment that favours tumour progression and fosters immunosuppression. Tumour cells survive this hostile environment by over-expressing pH regulatory molecules such as carbonic anhydrase (CA) IX, …
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Applications of Hair as a Record of Systemic Exposure to Cortisol
Hair cortisol content (HCC) is a novel biomarker that uniquely captures retrospective systemic cortisol exposure. This thesis aimed to assess how different hair growth rates effect HCC timelines in Cushing’s and Addison’s patients, investigate the relationship between HCC and age, puberty, sex and …
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TRANSFORMATION OF PRIMARY HUMAN HEPATOCYTES IN HEPATOCELLULAR CARCINOMA
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Currently, there is limited knowledge of neoplastic transformation of hepatocytes in HCC. In clinical practice, the high rate of HCC local recurrence suggests the presence of different hepatocyte populations within the liver …
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Alterations in Genomic 5-Hydroxymethylcytosine Level in Hepatocellular Cancer
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide. There are a limited number of therapeutic options currently available to delay the advancement of HCC, and the chance of survival decreases as the disease progresses. DNA methylation of certain tumor …
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Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and prognostic indicator in patients with hepatitis B virus-associated hepatocellular carcinoma
… and HBV-related hepatocellular carcinoma (HCC). DESIGN AND METHODS: The study enrolled 300 individuals (50 healthy controls, 50 with CHB, 100 with HBV-associated cirrhosis, and 100 with HBV-associated HCC). Serum ITIH4 levels were determined by western blot analysis and expressed in …
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Liver resection for hepatocellular and fibrolamellar carcinoma in a South African tertiary referral centre
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy in adults and is the fifth most common solid tumour worldwide with a variable prevalence based on underlying risk factors and geography. The incidence has risen over the past several decades and HCC is now the third leading …
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Diabetes and obesity as risk factors for the development of Hepatocellular carcinoma in the hispanic population
… of 6.9%. The well known etiological factors for HCC are infection with hepatitis B virus (HBV) and hepatitis C virus (HCV), alcohol abuse and environmental exposure to aflatoxins. The prevalence and mortality from HCC is rising in the U.S. In the U.S, Hispanics have a 2.7 times higher risk for …
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Differences in miR-122 and miR-191 Expression in HBV- versus HCV-associated Hepatocellular Carcinoma
… in HCV-associated hepatocellular carcinoma (HCC). The goal of this thesis is to assess miR-122 and miR-191 expression levels in HBV- and HCV-associated HCC, the related non-tumor tissue, and normal liver tissue. Relative quantification of miR-122 and miR-191 in 16 HCV-associated HCC, 10 …
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A Study of The Snd1/Prmt5 Axis In Liver Cancer By Genetic Mouse Models
… been implicated in hepatocellular carcinoma (HCC). SND1 has been confirmed as a driver of HCC using genetically engineered mouse models (GEMMs), though, it remains unknown if loss of SND1 or its methyl reading ability can protect against HCC formation. PRMT5 has been reported as upregulated in …
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