Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"HCA"”.
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Investigation of the effect of hydroxycitric acid on urinary calcium oxalate risk factors for kidney stone formation in artificial urine: theoretical modelling and in vitro crystallisation experiments
… was to establish whether hydroxycitrate (HCA) affects and/or inhibits calcium oxalate crystallisation. A three-pronged approach was adopted, involving the determination of thermodynamic binding constants for Ca, Mg and Zn-HCA complexes, theoretical modelling of HCA-complex formation in …
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Effects of hypercapnic acidosis on the primary cells relevant to acute respiratory distress syndrome pathophysiology and the therapeutic potential of Mesenchymal Stem Cells
… in the development of hypercapnic acidosis (HCA). While it was once believed that HCA exerts protective effects in such an environment, more recent data are controversial. However, much of these data have been derived from in vitro experiments using cell types which are of limited relevance …
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Thiazolidinone-isatin hybrids as multi-target anticancer agents
… isatin-thiazolidinone hybrids as inhibitors of hCA IX and hCA XII, four series of molecules were successfully synthesized and characterized. Biochemical tests performed on hCA I, hCA II, hCA IX, and hCA XII isoforms have shown promising results on the selectivity and activity of these new …
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Avaliação do estresse oxidativo no desenvolvimento da hipertensão renovascular : papel protetor dos estrogênios
… normotenso castrado (NCA) e hipertenso castrado (HCA). Foi induzida a hipertensão renovascular (modelo Goldblatt 2) por 21 dias e, concomitantemente, realizada a ovariectomia. Num grupo de animais, amostras de sangue foram coletadas no 3º, 10º e 20º dia. Em outros animais, os corações e rins foram …
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Is lower socio-economic status associated with more impaired health care access and poorer quality of life in patients with COPD? What is the role of psychosocial factors in this relationship?
… with decreased health care access (HCA) and poorer quality of life (QoL) in patients with COPD. The secondary aim examined whether psychosocial factors mediated the relationship between socio-economic status, health care access and quality of life.Methods: Cross-sectional, …
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The Use of American Precedent in Australian Constitutional Jurisprudence
… precedent by the High Court of Australia (HCA) could beneficially contribute to the ongoing doctrinal development of Australian constitutional jurisprudence. Useful concepts derived from United States (US) Supreme Court (USSC) case law have been under-explored to date, and an increased …
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"Fit objects for an asylum": The Hampshire County Lunatic Asylum and its patients, 1852-1899
… uses the records of the Hampshire County Asylum (HCA) between its<br/>opening in 1852 and the end of the nineteenth century to offer a different perspective<br/>on asylum history. Though it discusses the asylum in legal, medical and social welfare<br/>contexts it focuses on the experience of …
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Development of novel reactive oxygen species (ROS)-modulating agents and carbonic anhydrase inhibitors for the treatment of Pancreatic Ductal Adenocarcinoma and other resistant cancers
… (CAI) targeting the human isoforms IX and XII (hCA IX and XII) overexpressed in several cancer types. Additionally, I propose the development of a serie of multivalent inhibitors designed to optimize both selectivity and potency against different hCA isoforms.
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Automated platform for histological race and sex comparison of human cortical bone
… greater (p<0.05) in Indian samples (HCA: 0.457mm2) compared to Chinese samples (HCA: 0.385mm2) in the second decade. However in fifth decade, total area covered by Chinese samples (HCA: 0.894mm2) was significantly greater (p<0.05) than Indian samples (HCA: 0.570mm2). Three main steps …
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Modulatory Effects of Citrus Flavonoids Towards the Metabolism and Mutagenicity of Environmental Carcinogens
… carcinogens classified as heterocyclic amines (HCA’s) and the tobacco-specific nitrosamine NNK generally require internal enzymatic activation. This activation occurs via cytochrome P450 (CYP) enzymes and leads to metabolites that bind to human DNA which may in turn cause mutations which may …
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Phytochemical mediated resistance in sweetpotato to sweetpotato weevils
… difference in total hydroxycinnamic acid (HCA) esters among the genotypes of the segregating population. The distribution of genotype mean total HCA ester concentration was skewed to the left and only one progeny, NKB257, had higher total HCA ester concentration than New Kawogo, the …
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Embracing all God’s children : an embedded single case study of a K–12 Southern classical Christian school’s racial diversity.
Hope Christian Academy (HCA, pseudonym), a K–12 classical Christian school located in the Southern region of the United States, enrolled a significantly lower proportion of students of color than its peer institutions, which may impact the school’s overall sense of community. Located in a suburban …
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Who Cares? A Case Study to Explore Health Care Assistants' Jurisdiction in a Hospital Setting
… increasing concern about the ways in which HCAs are used and the basis for the division of nursing work tasks and roles. The theoretical and empirical foundations upon which these divisions lie are often weak. Empirical data are often lacking, or of sufficiently poor quality to be …
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The Mechanisms of wear of the video head
… video head increases linearly with increasing HCA content, signal degradation does not vary significantly. The most significant differences in wear and signal reproduction were observed between the two HCAs. The signal degradation of heads worn with tape samples containing A12O3 HCA was found …
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Investigating prospects of integrating spatial planning with disaster risk reduction in flood prone settlements of Greater Tzaneen Municipality of Limpopo Province in South Africa
… vulnerability, Hierarchical Cluster Analysis (HCA) was used. HCA was used to identify clusters of flood prone areas which had common characteristics in terms of the four main study constructs proposed by the study which included the physical/engineering, socio-economic, ecological/natural and …
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Outcome selection in longitudinal analysis of immunological data
… (PCA) and hierarchical cluster analysis (HCA) followed by PCA. PCA identifies the largest sources of variance across all outcomes, while HCA followed by PCA identifies variance within groups of similar outcomes. These techniques influence the definition of families of tests for false …
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Statistical Machine Learning for Multi-platform Biomedical Data Analysis
… namely the hybrid correlation-based association (HCA) to detect interacting SNPs. The HCA algorithm is based on three correlation-based statistics, which are designed to measure the strength of multi-locus interaction with three different interaction types, covering a large portion of possible …
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Exploring Health Care Aides' Perspectives on Work Life in Long-Term Care
… change in work life for health care aides (HCAs) in long-term care. Participatory action research (Reason & Bradbury, 2008) methodology was used to engage 10 HCA participants in a virtual focus group. The study explored the primary research question: How can we improve health care aides’ …
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RETROSPECTIVE DESCRIPTIVE STUDY ON POST-MARKET MEDICINE QUALITY-RELATED COMPLAINTS AND THE APPLICATION OF FIELD-BASED DETECTION OF POORQUALITY MEDICINES USING NEAR-INFRARED AND RAMAN SPECTROSCOPIC SCREENING METHODS
… and Hierarchical Clustering Analysis (HCA)) was developed for spectral anomaly detection with findings validated using High-Performance Liquid Chromatography (HPLC). The main findings demonstrate that NIR enabled rapid, non-destructive screening but showed limitations in sensitivity, …
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Carilion: A Corporate System of Managed Health Care
… system in order to compete with rival Columbia/HCA. This transformation required the creation of a physician management company and a health plans division. In 1995, Carilion's administrators began a reengineering program which redefined services and strategies for corporate growth. This …
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