Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"HC50"”.
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QUB-1957: a bioactive peptide from the frog skin secretion of Hylarana latouchii
… a certain degree of haemolytic rate, the HC50 is 47.82 μM. Besides, QUB-1957 exhibits no significant effect against PC3 (human prostate cancer cell line), NCI-H157 (human non-small cell lung cancer cell line), MCF-7 (human breast cancer cell line) and U251MG (human neuronal glioblastoma …
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Identification, isolation and bioactivity assessment of a bioactive peptide QUB-1465 from the skin secretion of Hylarana guentheri
… Also, its haemolytic activity was low with HC50 of 1.888mM. So QUB-1465 is promising antibacterial drug candidate.
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Identification and activity assessment of a bioactive peptide QUB-2642 from the skin secretion of The American Bullfrog (Rana catesbeiana)
… = 64 µM) without significant haemolytic effect (HC50 >512 µM) upon horse erythrocytes. With an α-helix in supposition, the second structure of QUB-2642 was tentatively calculated and discussed. Given the huge potential of endogenous peptides in drug discovery, further verification and …
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Evaluation of bioactivity of QUB1977 from the skin secretion of the frog, Phyllomedusa camba
… the test peptide which induced 50% haemolysis (HC50) was 23 μM. The results indicated that the discovered peptide can be potential drug candidates for the design of new and valuable anti-infective agents.<br/>
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Identification and characterisation of a novel antimicrobial peptide from the defensive skin secretion of the Heilongjiang brown frog, Rana amurensis
… (IC50=4.123µM) and strong haemolytic activity (HC50=14.21 µM). The results showed that QUB-2944 is a brevinin-2 peptide, which has value to be further developed as a drug candidate in the future.<br/><br/><i>Thesis embargoed until 31 December 2026</i>.
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Identification and functional study of a bioactive peptide QUB-1962 from the skin secretion of the yellow-bellied toad (Bombina variegata)
… and has relatively weak haemolytic activity (HC50 is 691.6 μl). The anti-cancer activity assay showed that the peptide had a significant anti-cancer effect (IC50: 3.471×10-5 M) on the tested human cancer cell glioblastoma U251 MG. According to the data of these biological activities, QUB-1962 …
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Discovery and functional evaluation of a host defense peptide from Rana amurensis
… (MIC=512μM), along with low haemolytic activity (HC50< 512 μM). Also, peptide QUB-2566 had a weak antiproliferative effect on lung cancer cells H838. Altogether, this peptide may become a lead compound for new antimicrobial drug development because of its potent antibacterial potency against …
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Identification and functional study of the bioactive peptide QUB-2417 from the skin secretion of the tree frog, Phyllomedusa bicolor
… test concentration (128 μM) and the value of HC50 was 690 µM. Hence, the peptide deserves serious attention as a potential therapeutic due to its potent relevant bioactivity and is expected to be optimised as a good drug candidate.<br/><i><br/>Thesis embargoed until 31 December 2026</i>.
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The discovery of a novel bioactive peptide, QUB-2575, from the defensive skin secretion of Pelophylax kl. esculentus
… red blood cells. QUB-2575 was haemolytic with an HC50 of 23.48 μM. QUB-2575 exhibited 0.72%, 7.97% and 16.38% haemolysis at the MIC (2 μM) against S. aureus, the MIC (4 μM) against C. albicans and the MIC (8 μM), against E. coli, respectively.
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A novel dermaseptin peptide from the defensive skin secretion of Phyllomedusa camba
… respectively. Besides, low haemolytic activity (HC50=114.7μM) were observed at effective concentrations, which ensures its safety in clinical use. In the future, after structure modification, the analogues of the peptide may have potential to be devel-oped into novel antibiotic against the …
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Assessing bioactivity of peptide QUB3203 from the skin secretion of the Edible frog Pelophylax kl. esculentus
… possessed moderate haemolytic activity with a HC50 of 101.2 μM.
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Molecular cloning, peptide synthesis and bioactive assessment of a skin defensive peptide, QUB-3117 from the skin secretion of Rana schmackeri
… against erythrocyte from horse blood with HC50 values of over 512 µM. Therefore, considering the significant inhibition on tumor cells and little cytotoxicity against erythrocyte, QUB-3117 possess the potential to be developed as drug candidate.
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Bioactivity assessment of a bioactive peptide, QUB-2022, isolated from the skin secretion of the tiger-striped leaf frog, (Phyllomedusa tomopterna)
… the half maximal haemolysis concentration (HC50) of QUB-2022 was 49.89 µM, which might limit the clinical use of that bioactive peptide and require optimization.<br/><br/><i>Thesis embargoed until 31st October 2024 </i>
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QUB-3170: a novel peptide with antimicrobial activities from the skin secretion of Phyllomedusa tarsius
… of them showed strong haemolysis activity at HC50 of 31.36 μM and 30.25 μM. The anticancer activity showed that QUB-3170 was active to H157 cancer cells with IC50 of 7.94μM, QUB-2987 was active to MCF-7 cancer cells with IC50 of 9.12μM. In this study, we discovered one novel antimicrobial …
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Structural and Biological Characterization of Antimicrobial Peptides from Rana Sylvatica and Kassina Senegalensis
… of peptide producing 50% hemolysis, HC50 = 54 pM) human red blood cells. Brevinin 1SY (Phe-Leu-Pro-Val-Val-Ala-Gly-Leu-Ala-Alalü-Lys-Val- Leu-Pro-Ser-lle-lle-Cys-Ala-Val20-Thr-Lys-Lys-Cys) contains an intramolecular disulfide bridge that forms a heptapeptide ring. In this study, …
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DEVELOPMENT OF NOVEL COPOLYOXETANES: ANTIMICROBIAL AGENTS
<p>This thesis focuses on solution antimicrobial effectiveness for copolyoxetanes with quaternary ammonium and PEG-like side chains. Ring opening copolymerization of 3-((4-bromobutoxy)methyl)-3-methyloxetane (BBOx) and 3-((2-(2-methoxyethoxy) ethoxy) methyl)-3-methyloxetane (ME2Ox) yielded random …