Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"HC11"”.
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Investigation of the role of CUZD1-STAT5 signaling in mammary gland development and breast cancer
… studies, using flag-tagged CUZD1 expressed in HC11 mouse mammary epithelial cells, revealed that CUZD1 associates with a multi-protein complex containing JAK1/JAK2 and STAT5. Elevated expression of CUZD1 in HC11 cells stimulated phosphorylation and nuclear translocation of STAT5. Chromatin …
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Cationic liposome-mediated transfection of mammary epithelial cells with AAV-based plasmid DNA
… DNA to the mouse mammary epithelial cell line, HC11, and to primary bovine mammary cells in vitro. Four delivery vehicles were used; calcium phosphate co-precipitation, DOTAP, DMRIE-C and LipofectAMINE. The highest transfection efficiency resulted from using LipofectAMINE, although this …
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Novel Rac1/Stat3 and Stat5 Pathway in Differentiation and Neoplastic Transformation of Breast Epithelial Cells: Potential Prognostic Markers
… that Stat3 is required for differentiation of HC11 breast epithelial cells, measured by β-casein expression. On the other hand, we also show that constitutively active Rac, a molecule downstream of cadherin in the Stat3 activation pathway, blocks the differentiation of breast epithelial cells. …
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Modeling Brk/PTK6 expression in the mammary epithelium.
… with Brk expression in non-transformed HC11 murine mammary epithelial cells. Additionally, non-transformed HMEC and HC11 cells expressing Brk exhibited increased anchorage-independent survival when cultured on PolyHEMA coated dishes. Samples from breast tumor biopsies were subjected to …
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Proteomic Analysis of Mammary Epithelial Cell Development
… different stages of mammary development. The HC11 cell line was used to investigate protein changes between undifferentiated and differentiated MEC, which represent the pregnant and lactating states of the cells. This comparison revealed an interesting differential expression profile …
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A promoter characterisation of the Ets transcription factor gene, Ese-2/Elf-5
… culture. The mammary gland derived cell lines HC11 and Comma1D were used, in conjunction with a chloramphenicol acetyltransferase reporter system. A region of sequence between -70 and -200bp was identified as having up-regulated transcriptional activity above an empty expression vector in cell …