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Showing 1 to 12 of 12 for “"HBx"”.
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Studies on Taxol Resistance Induced by HBx Viral Oncoprotein
… for the development of HCC.Hepatitis B virus X (HBx)protein encoded by HBV genome is likely to play a important role in development of HBV-related HCC In addition, I explored the role of HBx underlying resistance to taxol in HCC. Treatment with taxol(100nM and 1uM)led to induce celldeath in Chang …
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Regulation of cancer progression by hepatitis B virus X protein (HBx) and HBxAP/RSF1
… of catalase on hepatitis B virus X protein (HBx) in HBV-related advanced hepatocellular carcinomas 1 A. INTRODUCTION 2 B. MATERIALS AND METHODS. 4 1. Cell cultures and plasmids 4 2. RNA extraction, reverse transcription-polymerase chain reaction 4 3. Western blotting . 5 4. Luciferase assay 5 …
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The Effect of Primary Hepatocyte Expressing HBx on the Activation and Apoptosis of Antigen-specific CD8+ T Cell
… or inhibiting viral replication inside cells. HBx, antigen of hepatitis B virus, plays an important role in the immunopathogenesis of HBV infection. Since HBx is able to upregulate cellular expression level, it is thought that HBx may modulate CD8^(+) T cell immune response. To test this …
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바이러스 감염시 미토콘드리아 E3 ubiquitin ligase 인 MARCH5의 새로운 생체 기능
… degradation. Second, the hepatitis B virus X (HBx) is non-structural protein encoded by hepatitis B virus (HBV) genome. Highly expressed HBx accumulates at the mitochondria and induces mitochondrial dysfunction that contributes to the pathogenesis of liver cancer. I found that MARCH5 was …
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Charakterisierung humoraler und zellulärer Immunantworten gegen das Hepatitis-B-Virus X-Antigen mittels DNA-Immunisierung im Mausmodell
… Studien charakterisiert. Zunächst wurden HBx-Expressionsplasmide der beiden HBV-Subtypen ayw und adw kloniert und die entsprechenden Antigene in eukaryontischen Zellen exprimiert. Um eine effiziente MHC-Klasse-I Präsentation des X-Antigens zu erreichen, wurden HBx-spezifische …
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CHARACTERIZATION OF HEPATITIS B VIRUS (HBV) IN HEPATOCELLULAR CARCINOMA (HCC) PATIENTS
… viral structural alteration is at the 3¿-end of HBx where viral replication/transcription initiates. Upon integration, the 3¿-end of the HBx is often deleted. HBx-human chimeric transcripts, the most common type of chimeric transcripts, can be expressed as chimeric proteins. Sequence variation …
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IDENTIFYING THE ROLE OF TIP60 IN HEPATOCELLULAR CARCINOMA
… cancers, is downregulated in cells expressing HBx, an oncogene of HBV. This was through a proteasomal mechanism such that HBx utilizes an E3 ubiquitin ligase, EDD1/UBR5 to destabilize TIP60. In inflammation induced liver cancer, I found that TIP60 plays a role in modulating innate immune …
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Characterization of genetically distinct neuronal subtypes in the lateral habenula using Cre mouse lines
… subregions. These have been designated as the HbX, lateral, oval/medial, and marginal subregions of the LHb. Each subregion is marked by non-overlapping genes. Cre mouse lines can be used as a tool to target these genes and thus manipulate these subtypes. This project utilizes fluorescence in …
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An investigation of genome-wide promoter region cytosine-phosphate-guanine (CpG) Island methylation profiles in patients with chronic hepatitis B virus infection
… It integrates parts of its genome such as the HBx gene, core and surface antigens into the human genome. The integrated viral DNA disrupts gene function resulting in physiological changes that cause liver disease. The viral inserts are inactivated through methylation. This is a protective …
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IDENTIFYING EARLY STEPS IN THE DEVELOPMENT OF HBV ASSOCIATED HCC
… genes deregulated by the hepatitis B x-antigen (HBx), the oncogenic protein encoded by HBV, are known drivers of HCC.4,5 The timing of these alterations in the initiation and progression of disease, however, are poorly understood and the treatment options for HCC are extremely limited. Here, …
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AMP-activated protein kinase-mTOR signaling pathway and hepatitis B virus replication
… 활성이 필요하며 이를 통해 바이러스 복제에 필요한 지질을 합성한다. HBV X 단백질(HBx)은 mTOR의 활성을 증가시켜 hepatocellular carcinoma(HCC) 세포의 증식을 유도한다. 본 연구에서는 HBV가 증식할 때 AMPK와 mTOR의 활성에 변화가 있는지 알아보았고, AMPK-mTOR 신호전달 과정의 변화가 HBV 증식에 영향을 미치는지 알아보고자 하였다. HCC 세포인 HepG2세포에서 유래한 HBV 가 증식하는 HepG2.2.15세포, PEB 세포와 Huh7세포에서 유래한 HBV 가 증식하는 Huh7 …