Global ETD Search
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Showing 1 to 15 of 15 for “"HBV replication"”.
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C-terminus of Hepatitis B virus RNase H Domain is Important for HBV replication
Hepatitis B Virus (HBV) DNA polymerase (P) protein consisting of terminal protein (TP), spacer, reverse transcriptase (RT), and RNase H, plays critical roles in viral assembly and replication. RNase H domain is required for HBV DNA replication, however critical motif or amino acid residues in the …
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Critical C-termical Amino Acids of Hepatitis B Virus Core Proteins for HBV Replication
… protein, DNA polymerase, X protein을 발현한다. HBV core protein은 183개 또는 185개의 amino acid로 구성되어있는 22kDa의 단백질이며, HBV core protein은 pgRNA 의 encapsidation 및 DNA 합성에 관여하는 것으로 알려져 있다. HBV core protein은 기능적으로 두 부위로 나뉜다. core particle 조립에 관여하는 core protein 의 N-말단부위와 핵산과 결합하는 부위인 C-말단부위로 나뉜다. Core …
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Roles of Interferon Lambda on Hepatitis B Virus Replication
"Background/Aims: Chronic hepatitis B virus (HBV) infection is a major cause of liver disease. Only interferon-α (IFN-α) and the nucleosidic inhibitors of the viral polymerase, lamivudine and adefovir, are approved for therapy. However, these therapies are limited by the side effects of interferon …
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MOLECULAR BIOLOGY OF HEPATITIS B VIRUS DNA-CELL INTERACTION
Liver-specificity of hepatitis B virus (HBV) replication has been attributed to the action of its second enhancer (EII). This thesis reports the characterization of EII and the subsequent isolation of a novel liver-specific DNA-binding protein which binds to, and activates EII. The cDNA clone of …
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Functional Role of Hepatitis B Virus Core Protein in Viral Replication
… carboxyl-terminal nucleic acid binding domain of HBV core protein for hepatitis B virus (HBV) replication, chimeric HBV core proteins were generated by substituting varying lengths of the carboxyl-terminus of duck hepatitis B virus (DHBV) core protein for the corresponding regions of HBV core …
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Cytokine gene transfer by adenoviral vectors as a novel therapeutic option for hepatitis B virus infection
Hepatitis B virus (HBV) is a hepatotropic, non-cytopathic DNA virus that causes acute and chronic necroinflammatory liver disease and hepatocellular carcinoma. It has been shown that HBV DNA replication is suppressed by interferon (IFN) a/b, IFNg and other cytokines. The aim of my thesis was to …
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Analysis of Treatment Effect of Lamivudine, Adefovir Add-on Therapy in Patients with Lamivudine Resistant Chronic B-viral Hepatitis
… therapy. Liver function test, hepatitis B virus (HBV) DNA and HBeAg/HBeAb were assessed every 3 months. ADV associated (rtA181T/V and rtN236T) mutations were looked for at intervals in all HBV DNA-positive serum samples, yearly Results: Cumulative ratio of undetectable HBV DNA level (<50 copies/mL …
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The Intracellular Changes and the Localization of Core particles by Hepatitis B Virus P Protein-Deficient Mutant
PURPOSE: Hepatitis B virus (HBV) core particles move to ER or recycle back to the nucleus. This moving mechanism is thought to be important in HBV replication and HBV life cycles. P protein-deficient mutant can form core particles in the absence of P protein and pregenomic RNA (pgRNA). In this …
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Phenotypic characterization of a clinical HBV/G isolate relative to a co-infecting HBV/A strain and HBV/A/G recombinant strains
Hepatitis B virus genotype G (HBV/G) is a unique genotype of HBV which contains a 36-nucleotide insertion in the Core gene as well as 2 mutations that lead to stop codons in the Pre-Core coding region. Chronic infection with HBV/G is not known to occur without a co-infecting HBV genotype, …
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Hepatitis B Virion and cccDNA Formation in Primary Tupaia Hepatocytes and Human Hepatoma Cell Lines upon HBV Genome Transduction with Replication-defective Adenovirus Vectors and in vivo Infection of Tupaias
Hepatitis B virus (HBV), the causative agent of B-type hepatitis in humans, is a hepatotropic DNA-containing virus that replicates via reverse transcription. Because of its narrow host range there is as yet no feasible small animal system for HBV infection. Some evidence suggests that tree shrews …
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Relationship between Hepatitis B Virus Core Particles and Intracellular Motility
PURPOSE: Hepatitis B virus (HBV) core particles recycle back to the nucleus. This recycling mechanism is thought to be important in maintaining covalently closed circular (cccDNA) pool in the nucleus. Transport of HBV core particles in host cytoplasm is important for HBV life cycle but the …
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Immune Control of Hepatitis B Virus infection by innate lymphocytes
Hepatitis B virus (HBV) infects over 300 million people worldwide and despite the availability of a vaccine, it remains the second biggest carcinogen in the world and a serious global health problem. The majority of adult infections are resolved while 90% of neonates fail to clear infection. …
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Compartmental Hepatitis B Virus (HBV) Evolution, Replication and Infectivity in vivo and ex vivo
Hepatitis B Virus (HBV) is classically considered a hepatotropic virus, however, the presence of different HBV genomic molecules in lymphoid cells and tissues support its lymphotropic nature. Our previous studies showed that HBV evolved in a compartment- and disease phase-specific fashion. However, …
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Expression and Functional Analysis of Hepatitis B Virus DNA Polymerase
… and duck hepatitis B virus Hepatitis B Virus (HBV) DNA polymerase is a multifunctional protein with four domains, terminal protein (TP), spacer, reverse transcriptase (RT), and RNaseH. Since HBV DNA polymerase is very unstable and rapidly degradable, it has been very difficult to study the …
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Initial Stages of Hepatitis B Virus Replication
PART 1 Intracellular Trafficking of HBV Core Particle in Various Stage of DNA Replication Inside of hepatitis B virus (HBV) core particle, pgRNA is reverse transcribed by HBV DNA polymerase into minus-strand DNA and pregenomic RNA (pgRNA) is degraded concomitantly by RNase H activity of DNA …