Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 124 for “"HBV"”.
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Phenotypic characterization of a clinical HBV/G isolate relative to a co-infecting HBV/A strain and HBV/A/G recombinant strains
Hepatitis B virus genotype G (HBV/G) is a unique genotype of HBV which contains a 36-nucleotide insertion in the Core gene as well as 2 mutations that lead to stop codons in the Pre-Core coding region. Chronic infection with HBV/G is not known to occur without a co-infecting HBV genotype, …
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IDENTIFYING EARLY STEPS IN THE DEVELOPMENT OF HBV ASSOCIATED HCC
The hepatitis B virus (HBV), chronically infecting ~360 million people worldwide, accounts for over half of the cases of hepatocellular carcinoma (HCC) and contributes to over 650,000 deaths per year making HCC is the fifth most common and second most deadly form of cancer.1-3 Many genes …
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Constraints on the CD8 T cell response in chronic HBV infection
… in CHB, and show preferential suppression of HBV-specific CD8 T cells compared to responses for other viruses by IL- 10 blocking experiments. Circulating IL-10 levels were elevated in patients and correlated temporally with viral load and ALT (surrogate marker of liver inflammation) during …
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CHARACTERIZATION OF HEPATITIS B VIRUS (HBV) IN HEPATOCELLULAR CARCINOMA (HCC) PATIENTS
Chronic Hepatitis B Virus (HBV) infection is epidemiologically associated with hepatocellular-carcinoma (HCC) but its role in HCC remains poorly understood due to technological limitations. Here, we systematically characterize HBV in HCC patients. HBV sequences were enriched from 48 HCC patients …
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The role of PLK1 in Hepatitis B Virus (HBV) infection of the liver
… chronic infections globally, Hepatitis B Virus (HBV) is a major human health issue, linked to increased risk for development of hepatocellular carcinoma (HCC). Current treatments to control chronic HBV infection remain ineffective. New and effective therapies that target the persisting viral …
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Serologic markers and molecular pidemiology of HBV in an HIV infected cohort from Cameroon
See the attached abstract below
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Compartmental Hepatitis B Virus (HBV) Evolution, Replication and Infectivity in vivo and ex vivo
Hepatitis B Virus (HBV) is classically considered a hepatotropic virus, however, the presence of different HBV genomic molecules in lymphoid cells and tissues support its lymphotropic nature. Our previous studies showed that HBV evolved in a compartment- and disease phase-specific fashion. However, …
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C-terminus of Hepatitis B virus RNase H Domain is Important for HBV replication
Hepatitis B Virus (HBV) DNA polymerase (P) protein consisting of terminal protein (TP), spacer, reverse transcriptase (RT), and RNase H, plays critical roles in viral assembly and replication. RNase H domain is required for HBV DNA replication, however critical motif or amino acid residues in the …
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Critical C-termical Amino Acids of Hepatitis B Virus Core Proteins for HBV Replication
… protein, DNA polymerase, X protein을 발현한다. HBV core protein은 183개 또는 185개의 amino acid로 구성되어있는 22kDa의 단백질이며, HBV core protein은 pgRNA 의 encapsidation 및 DNA 합성에 관여하는 것으로 알려져 있다. HBV core protein은 기능적으로 두 부위로 나뉜다. core particle 조립에 관여하는 core protein 의 N-말단부위와 핵산과 결합하는 부위인 C-말단부위로 나뉜다. Core …
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Comparison of Serum HBV DNA Levels between Lamivudine Induced HBeAg Seroconversion and Spontaneous Seroconversion
… B. The aim of this study was to compare serum HBV DNA levels at the time of HBeAg seroconversion between these two groups. METHODS: We retrospectively analyzed 37 patients with chronic hepatitis B. Among them, 14 were seroconverted during lamivudine therapy and 13 were not seroconverted during …
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ESTABLISHING AN IN VITRO MODEL FOR CRISPR-CAS9 SCREENING OF INTERFERON EFFECTORS IN HBV INFECTION
Hepatitis B virus (HBV) is a hepatotropic virus that can cause both acute and chronic liver infection. According to the World Health Organization, 254 million people were living with chronic hepatitis B virus (CHB) infection in 2022, with approximately 1.2 million new cases each year. While …
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Differences in miR-122 and miR-191 Expression in HBV- versus HCV-associated Hepatocellular Carcinoma
… assess miR-122 and miR-191 expression levels in HBV- and HCV-associated HCC, the related non-tumor tissue, and normal liver tissue. Relative quantification of miR-122 and miR-191 in 16 HCV-associated HCC, 10 HBV-associated HCC, the respective neighboring non-tumor tissue, and 9 normal liver …
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HBV genotypes at the Groote Schuur Hospital Liver Clinic, Cape Town : genotype and subgenotype prevalence and the influence of ethnicity on treatment outcomes during long term clinical follow-up of patience with chronic HBV infection.
In the developing world, hepatitis B virus (HBV) is an important cause of acute and chronic liver disease. Two billion people worldwide are infected with the virus and an estimated 350 million who have failed to clear the virus have chronic infection. In Africa, HBV is endemic with 98% of the …
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Identifizierung und Charakterisierung viraler und zellulärer Komponenten, die an den frühen Schritten der HBV-Infektion beteiligt sind
Das humane Hepatitis B Virus (HBV) zeichnet sich durch eine enge Wirtsspezifität und einen ausgeprägten Lebertropismus aus. Diese Eigenschaften werden überwiegend von den frühen Schritten der Infektion bestimmt. So produzieren Maushepatozyten mit stabil integriertem HBV-Genom zwar infektiöse Viren, …
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Relationship between Hepatitis B Virus Core Particles and Intracellular Motility
PURPOSE: Hepatitis B virus (HBV) core particles recycle back to the nucleus. This recycling mechanism is thought to be important in maintaining covalently closed circular (cccDNA) pool in the nucleus. Transport of HBV core particles in host cytoplasm is important for HBV life cycle but the …
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Expression and Functional Analysis of Hepatitis B Virus DNA Polymerase
… and duck hepatitis B virus Hepatitis B Virus (HBV) DNA polymerase is a multifunctional protein with four domains, terminal protein (TP), spacer, reverse transcriptase (RT), and RNaseH. Since HBV DNA polymerase is very unstable and rapidly degradable, it has been very difficult to study the …
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An Assessment of Quality of Life among Hepatitis B Virus Carriers in China
Hepatitis B virus (HBV) is a serious public health problem in China. The quality of life (QOL) of the HBV carriers could be affected not only by the ailment and treatment, but also by social discrimination. The purpose of the this study was to assess the QOL of HBV carriers and to investigate the …
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