Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"HBOC"”.
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Perspectives and Experiences of Individuals Undergoing Predictive Testing for Hereditary Breast and Ovarian Cancer (HBOC) Syndrome in the Western Cape, South Africa.
… globally. Hereditary breast and ovarian cancer (HBOC) syndrome is caused by pathogenic variants in BRCA1 and BRCA2 and is seen in approximately 50% of families with a strong history of breast and ovarian cancers. Predictive testing (PT) is offered to unaffected individuals with a positive family …
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Knowledge, Attitudes, and Utilization of Brca Testing Among Obstetricians and Gynecologists
<p>Hereditary breast and ovarian cancer (HBOC) is an inherited cancer syndrome that is associated with mutations in the <em>BRCA1</em> and <em>BRCA2</em> genes. Carriers of <em>BRCA</em> mutations, both men and women, are at an increased risk for developing certain cancers. Carriers are most …
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The Effects of Hemoglobin-Based Oxygen Carriers On Mean Arterial Pressure, Arteriolar Diameter, and Nitric Oxide in the Microcirculation
… is focusing on hemoglobin-based oxygen carriers (HBOCs), which are limited in clinical application due to the pressor effect they induce. In this study, the mechanisms through which HBOCs affect mean arterial pressure (MAP), arteriolar diameter, and nitric oxide levels in the microcirculation were …
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Cancers Associated With Brca1 and Brca2 Mutations Other Than Breast and Ovarian
… Hereditary Breast and Ovarian Cancer syndrome (HBOC) through accumulation of unrepaired DNA damage. Extensive research of <em>BRCA1</em> and <em>BRCA2</em> mutations has led to well-defined breast and ovarian cancer risks in individuals with HBOC. Previous studies have reported additional …
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Accuracy of The Brcapro Risk Assessment Model In Males Presenting to Md Anderson For Brca Testing
… <p>Hereditary Breast and Ovarian Cancer (HBOC) syndrome is due to mutations in <em>BRCA1</em> and <em>BRCA2</em> genes. Women with HBOC have high risks to develop breast and ovarian cancers. Males with HBOC are commonly overlooked because male breast cancer is rare and other male cancer …
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Erythrocyte-Associated Transients in Capillary PO2 in the Rat Spinotrapezius Muscle During Hemodilution with Hespan and a Hemoglobin-Based Oxygen Carrier
… Hespan and a hemoglobin-based oxygen carrier (HBOC) on erythrocyte-associated transients (EATs) in capillary PO2. The particulate nature of blood flow in capillaries, when observed from a stationary observation point, results in fluctuations of PO2 as alternating red blood cells and plasma gaps …
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Managing Susceptibility to Hereditary Breast and Ovarian Cancer
… to hereditary breast and ovarian cancer (HBOC). Thirty North American women ranging in age from 22 to 60 years responded to open-ended interviews. These interviews were analyzed using constant comparative method to generate a grounded theory. Managing Susceptibility was identified as the …
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Evaluating The Nccn Clinical Criteria For Hereditary Breast and Ovarian Cancer Syndrome Genetic Testing
<p>Hereditary Breast and Ovarian Cancer (HBOC) syndrome predisposes females with a <em>BRCA1</em> or <em>BRCA2</em> mutation to an up to 85% lifetime risk for breast cancer and an up to 40% lifetime risk for ovarian cancer. It is crucial for individuals with HBOC to be identified to allow for …
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Assessing the impact of non-coding mutations on breast cancer risk predisposition genes
… with a Hereditary Breast or Ovarian Cancer (HBOC) has led to an improved understanding of the disease in some aspects, such as women with BRCA mutations. However, this is not the case for BRCAx patients (women diagnosed with a HBOC of unknown genetic cause), whose genetic predispositions are …
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ONCOGENETIC AND DECISION MAKING PROCESS. MEN¿S ADHERENCE TO CASCADE SCREENING FOR HEREDITARY CANCER SYNDROMES.
… as barriers and promoting factors to CS for HBOC. Conclusions. Our findings offer valuable insights for future interventions targeting at-risk male relatives. Gender-specific educational materials, continued education, and public awareness campaigns highlighting male involvement in HBOC …
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Identifying Pathogenic Variants In Hereditary Cancer Syndrome Genes Via Tumor Molecular Profiling
… testing (72.73% of patients with testing had HBOC-related tumors vs. 36.23% of those without testing, p BRCA1/2 mutations, particularly in non-<em>BRCA1/2</em> associated cancer types.</p>
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Predictors of Contralateral Breast Cancer In Brca Negative Women
… Hereditary breast and ovarian cancer syndrome (HBOC) is caused by mutations in the <em>BRCA1</em> and <em>BRCA2</em> genes. Women carrying a mutation in these genes are at an increased risk to develop a second breast cancer. Contralateral breast cancer is the most common second primary cancer in …
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Factors Associated With Early Versus Late Development of Breast and Ovarian Cancer In Brca1 and Brca2 Positive Women
Hereditary breast and ovarian cancer (HBOC) is caused by a mutation in the BRCA1 or BRCA2 genes. Women with a BRCA1/2 mutation are at increased risks for breast and ovarian cancer and often develop cancer at an earlier age than the general population. However, some women with a BRCA1/2 mutation do …
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Spectrum and Incidence of Primary and Therapy-Related Hematologic Malignancies In Individuals With Brca1 and Brca2 Pathogenic Variants
<p>Therapy-related myeloid neoplasms (t-MN) are rare and deadly hematologic malignancies that develop following exposure to cytotoxic therapies such as radiation, chemotherapy, and poly (adenosine diphosphate-ribose)-ADP polymerase (PARP) inhibitors. Preliminary evidence suggests that germline …
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Cancer Incidence In First and Second Degree Relatives of Brca1 and Brca2 Mutation Carriers
<p>Mutations in the <em>BRCA1</em> or <em>BRCA2</em> genes are associated with increased risks for breast, ovarian, and several other cancers. The purpose of this study was to evaluate the incidence of cancers in first and second degree relatives of <em>BRCA</em> mutation carriers compared to the …