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Showing 1 to 20 of 27 for “"HBF"”.
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Determinanti genetici dell’espressione dell’emoglobina HbF
Background: Increased levels of fetal hemoglobin (HbF, α2γ2) may reduce beta thalassemia severity. We have investigated the influence of three known major loci on the HbF trait (HBG2, rs7482144; BCL11A, rs1427407; HBS1L-MYB, rs9399137), prevalent Sardinian mutations in human Kruppel-like factor 1 …
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Bakterielle Kontamination von HbF-Erythrozytenkonzentraten aus Plazentarestblut
Plazentablut kann unter anderem zur autologen Transfusion von Frühgeborenen verwendet werden. Dabei ist die Kontamination von Plazentablut ein wichtiger limitierender Faktor für die klinische Verwendung. In dieser Studie wurde die Kontaminationsrate von Plazentablutentnahmen untersucht, wobei die …
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Utilizzo della tecnologia microchip per l'identificazione di geni candidati responsabili dell'aumento di HbF.
Expression of fetal globin is silenced normally in adult life; however, determinants linked and/or unlinked to the globin-gene clusters could modify Hb F expression so it persists into adults. Increased expression in adults offers hope as a cure for sickle cell disease (SCD) and b thalassemia, …
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New predictive and diagnostic biomarkers for preeclampsia
… of the genes coding for fetal hemoglobin (HbF) in preeclamptic placentas. The cell-free HbF protein was shown to be accumulating in the vascular lumen, to induce oxidative stress, which damages the blood-placenta-barrier, causing a leak into the maternal blood circulation. Unbound cell-free …
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Adaptive and Robust Multi-Gigabit Techniques Based MmWave Massive MU-MIMO Beamforming For 5G Wireless and Mobile Communications Systems. A Road Map for Simple and Robust Beamforming Scheme and Algorithms Based Wideband MmWave Massive MU-MIMO for 5G Wireless and Mobile Communications Systems
… modified algorithms of Hybrid Beamforming (HBF) approaches in indoor/outdoor scenarios over large scale fading wideband mmWave /Raleigh channels. Firstly, three beamforming based diagonalize the Equivalent Virtual Channel Matrix (EVCM) schemes with the optimal linear combining methods are …
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Genetic basis of hereditary persistence of fetal haemoglobin
… the variations observed in fetal haemoglobin (HbF) levels. This is important as it is known that an elevated HbF level can ameliorate the symptoms of many of the haemoglobinopathies. The frequency and range of hereditary persistence of fetal haemoglobin (HPFH) in the UK population was …
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Study of genetic modifiers of fetal hemoglobin and mechanisms of hydroxyurea-induced γ-globin expression in sickle cell disease
… since been associated with fetal hemoglobin (HbF), the disease-ameliorating globin protein, including variants at three principal loci; BCL11A, HBS1L-MYB intergenic polymorphisms (HMIP1/2) and the β-globin gene cluster, which together account for 10 - 20% HbF variance in SCD patients. …
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Characterisation of two genetic loci involved in fetal haemoglobin production: BCLIIA and HBSIL-MYB intergenic region
The continuous production of fetal haemoglobin (HbF, a2Ya) into adulthood is an ameliorating factor in sickle cell disease and B-thalassemia. We have previously mapped two quantitative trait loci (QTLs) controlling HbF levels, one in intron 2 of BCL11A gene, and the other, an intergenic region on …
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Análise funcional do gene FOXO3 na indução de hemoglobina fetal em células K562
… com o aumento dos níveis de hemoglobina fetal (HbF; α2γ2). O único fármaco autorizado pelo Food and Drug Administration (FDA) é a hidroxiureia, que mesmo sendo eficiente para manutenção e controle do desenvolvimento das principais manifestações clínicas destes pacientes, necessita de …
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ΕΠΙ ΤΗΣ ΕΝΕΡΓΟΠΟΙΗΣΕΩΣ ΤΗΣ ΕΜΒΡΥΙΚΗΣ ΑΙΜΟΣΦΑΙΡΙΝΗΣ ΕΙΣ ΤΟΝ ΕΝΗΛΙΚΟΝ
… MECHANISMS RESPONSIBLE FOR THE ACTIVATION OF HBF IN THE ADULT AND B) THE CHARACTERIZATION OF FACTORS THAT STIMULATE THE PRODUCTION OF HBFIN THE ADULT. TWO MAJOR PARTS OF EXPERIMENTS ARE DESCRIBED: 1) PHARMACOLOGIC STIMULATION OF HBF IN VIVO IN BABOONS AND MICE USING CYTOTOXIC DRUGS, …
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Genomic Characterization of Sickle Cell Mouse Models for Therapeutic Genome Editing Applications
… resulting in a shift from fetal hemoglobin (HbF, α2γ2) to adult hemoglobin (HbA, α2β2). Some individuals harbor rare genetic variants in the extended β-globin gene cluster that cause constitutively elevated postnatal HbF, a benign condition known as hereditary persistence of fetal hemoglobin …
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Genomics of sickle cell disease and fetal hemoglobin in African populations
… is therefore an imperative. Fetal hemoglobin (HbF) has long been recognized to ameliorate SCD severity whereby patients harboring natural genetic variations that lead to the persistence of high HbF levels in their blood tend to live longer with fewer complications. The HbF quantitative trait is …
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Συσχέτιση γονιδιωματικών βιοδεικτών σε γονίδια της οικογένειας KLF με τα επίπεδα της εμβρυικής αιμοσφαιρίνης στον άνθρωπο : προεκτάσεις στην εξατομίκευση της θεραπείας με υδροξυουρία ασθενών με β-τύπου αιμοσφαιρινοπάθειες
… αύξηση των επιπέδων της εμβρυικής αιμοσφαιρίνης HbF, προς βελτίωση της κλινικής εικόνας των ασθενών. Η μοναδική φαρμακευτική ουσία που έχει λάβει την έγκριση του Οργανισμού Τροφίμων και Φαρμάκων των Ηνωμένων Πολιτειών Αμερικής (FDA) για την επαγωγή της HbF σε δρεπανοκυτταρικούς ασθενείς είναι η …
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Caratterizzazione strutturale e funzionale dei sistemi emoglobinici di due specie di pesci (Mugil cephalus e Ophisurus serpens) e di due varianti emoglobiniche umane (HbRoma e HbF-SS-Monserrato)
… never described before, that we have named HbF-Monserrato-Sassari [Gγ93(F9) Cys Arg] and Hb Roma [β115(G17)Ala Val], and the hemoblobin systems of two species of fish, Mugil cephalus and Ophisurus serpens. HbF-Monserrato-Sassari [Gγ93(F9) Cys Arg] is an abnormal fetal hemoglobin observed in …
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Pentamethylcyclopentadienyl Osmium Chemistry: An Approach to Transition Metal Alkane Complexes
… of $\rm(C\sb5Me\sb5)Os(PMe\sb3)\sb2Me$ with $\rm HBF\sb4{\cdot}Et\sb2O$ at room temperature affords the Os$\sp{\rm IV}$ alkyl hydride complex $\lbrack\rm(C\sb5Me\sb5)Os(PMe\sb3)\sb2Me(H)\rbrack\lbrack BF\sb4\rbrack.$ Protonation of $\rm(C\sb5Me\sb5)Os(dmpm)Me$ at ${-}120\sp\circ$C with …
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Identificazione e analisi funzionale di fattori regolatori dei geni globinici
… cluster associated with fetal hemoglobin (HbF) levels, number of F cell and β-thalassemia severity: the HBS1L-MYB intergenic region and the BCL11A gene. In order to understand the functional role of the associated variants at these loci we applied “Genome Wide Chromosome Conformation …
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Pharmacogenomics of sickle cell disease therapeutics: pain and drug metabolism associated gene variants and hydroxyurea-induced post-transcriptional expression of miRNAs
… of disease severity, such as fetal hemoglobin (HbF) levels and αthalassemia, other genetic variants might influence specific sub-phenotypes. New treatments and management strategies accounting for these genetic and nongenetic factors could substantially and rapidly improve the quality of life …
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On new allotropes and nanostructures of carbon nitrides
… process to yield the heptazine based frameworks, HBF-1 and HBF-2. Due to the structural motifs of their molecular precursors, individual sheets of HBF-1 and HBF-2 span cavities of 14.2 Å and 23.0 Å respectively which makes both materials attractive as potential organic zeolites. Crystallographic …
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Synthesis and characterization of novel polyaniline/metal composites
… for the doped PANI/Au composite relative to PANI/HBF4 without Au particles. In the case of the PANI/Pt composite, the polymer is found to exist as an amine salt leading to diminished conductance for the doped PANI/Pt composite relative to PANI/HBF 4 without Pt particles. Most importantly, the data …
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Steric and Electronic Effects Induced by Ancillary Ligand Substitutions on Cyclopentadienyl Osmium Complexes
… (C5H5)Os(dmpm)H, which can be protonated with HBF 4·Et2O to afford [(C5H5)Os(dmpm)H 2][BF4]. Comparison of the X-ray crystal structures of (C 5H5)Os(dmpm)H and (C5Me5)Os(dmpm)H revealed no significant differences. In contrast, comparison of the structures of [(C5H5)Os(dmpm)H2+] and …
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