Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"HAS2"”.
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Correlation of HAS2-associated gene duplications with biological aggressiveness of mast cell tumors in Chinese Shar-Pei dogs
… upstream of the hyaluronic acid synthase 2 gene (HAS2). The objective of this study was to evaluate the relationship between HAS2, cutaneous mucinosis, and features of mast cell tumor (MCT) aggressiveness in Shar-Pei dogs. Biopsies of cutaneous MCTs from 149 Shar-Pei and 100 non-Shar-Pei were …
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Synthesis of Hyaluronan by Tumour Cells – Mechanism and Implications
… microenvironment (EGF, VEGF and TGF). Levels of HAS2/3 and HA production were measured using immunocytochemistry and a quantitative assay. HAS2 production was promoted in SCC epithelial cells, which corresponded with an increase in HA production.<br/><br/>Regarding phenotype, the addition of HA …
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The ageing hair follicle environment. Alterations in the female scalp and mesenchyme with age.
… (VCAN) expression. Hyaluronic acid synthase 2 (HAS2) was highly expressed throughout the scalp. Matrix Metallopeptidase 1 (MMP1) and Metallopeptidase inhibitor 1 (TIMP1), cyclin-dependent kinase inhibitor 2A (p16INK4A), 11β-Hydroxysteroid dehydrogenase type 1 and 2 (11β-HSD1/HSD11B1 and …
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The role of the extracellular matrix in neuronal development and perinatal brain injury
… with short hairpin RNA (shRNA) constructs for HAS2 or HAS3 knockdown (Aim 3). For these studies, neurons were imaged live or labelled with structural markers, and then traced using Neurolucida software to assess morphological changes at DIV1–3 or DIV7. Aim 4 utilised the near-term (0.85 …
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The Role of TBX3 In Early Breast Cancer Progression
… cells also had elevated hyaluronan synthase 2 (HAS2) levels and high levels of hyaluronan retention. These factors may contribute to the survival of cells and promote angiogenesis, allowing the formation of primary tumors in vivo. In conclusion, I have found evidence for a role of TBX3iso1 and …
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Developing a Drug Delivery System for Treatment of Vocal Fold Scarring
… up-regulation for all genes tested, except for HAS2 and decorin. Meanwhile, changes in RGD concentration only increased elastin and collagen type 3 alpha 1 expression as RGD concentration was increased in scarred vocal fold fibroblasts only. HAS2 was also down-regulated in scarred fibroblasts at …
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Development of Vessels, Airways and Cartilage Rings: The role of T-box genes
… including, extracellular matrix molecules Vcan, Has2, Itgα5; transcription factors Snai1 and Twist, and signaling molecules Bmp2, Bmp7, Notch2, Jag1 and Wnt2In addition, we show that the canonical Wnt signaling pathway contributes to the vessel-forming potential of the allantois. Ex vivo, the …
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Supplementing IL6, IL11, and LIF to Improve Cultured Bovine Oocyte Competency
… oocyte competency (CX43, CX37, AREG, TNFAIP6, HAS2). Our chosen housekeeping gene, HPRT1, served as the internal control. An increased abundance of AREG occurred following exposure to LIF but not with the other treatments. Supplementation with IL6 and IL11 but not LIF tended to increase TNFAIP6 …
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Src Kinase Regulates TGFβ And Hyaluronan Induced Epicardial Cell Invasion, Differentiation And Migration
… Mouse embryos lacking Hyaluronan Synthase 2 (Has2) are lethal at E 9.5 as a result of severely blocked cardiogenesis due to insufficient endocardial EMT. HA serves structural and bioactive functions in its capacity to stimulate signal transduction pathways required for EMT. Src kinase is a …
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Βιοχημικές και ανοσοβιολογικές μεταβολές των πρωτεογλυκανών σε κακοήθη νεοπλάσματα του γαστρεντερικού συστήματος
… την κυτταρική ανάπτυξη. Από την άλλη πλευρά, η HAS2 εμφάνιζε μικρή σταδιο-εξαρτώμενη αύξηση, μόνο στα καρκινικά δείγματα, η οποία μπορεί να οδηγήσει στη βιοσύνθεση μεγαλομοριακού υαλουρονικού, που απαιτείται για τη σωστή και οργανωμένη ανάπτυξη του καρκινικού όγκου. Τέλος, η HAS3 εμφάνιζε μικρή …
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Role of Nudt21 Mediated Alternative Polyadenylation and Hyaluronan In The Development of Pulmonary Hypertension
<p>Pulmonary hypertension (PH) is a progressive disease with serious effects on quality of life and life expectancy of patients. PH is a complex disease that likely develops due to multiple influences, and no curative treatments exist for this disease. It has been shown that alternative …