Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"H5N1"”.
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H5N1 Influenza Virus Induces a Parkinsonian Pathology
… at this time is posed by the highly pathogenic H5N1 avian influenza virus. To date, 63% of the 436 known human cases of H5N1 infection have proven fatal. Animals infected by H5N1 viruses have demonstrated acute neurological signs ranging from mild encephalitis to motor disturbances and coma. …
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Impact of Adjuvants on the Antibody Responses to Pre-pandemic H5N1 Influenza Vaccines
… with highly pathogenic avian influenza A (H5N1) viruses presented a serious public health challenge. Additionally, H5N1 viruses caused significant agricultural and economic losses in the communities it has affected. Human infections with these viruses are rare but when they occur, these …
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NS1 of H5N1 Interacts with SAP-97 in a PDZ-dependent Manner to Disrupt Epithelial Barrier Integrity
… The current outbreak of avian influenza (H5N1) that began in 1997 is still claiming lives, and therefore efforts to understand the mechanisms of pathogenesis in this highly virulent virus are of the utmost importance. According to the World Health Organization, there have been 447 reported …
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The Highly Pathogenic Avian Influenza A(H5N1) Virus: a twenty-year journey of narratives and (in)secure landscapes
… about the highly pathogenic avian influenza H5N1virus. In the first manuscript, I explore three narratives that have been produced to describe the 20-year journey of the virus. The journey begins in 1996 when the virus was a singular localized animal virus but then over the next 20 years …
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The role of domestic ducks in the maintenance and spread of avian influenza viruses in Indonesia
… understood. Highly pathogenic avian influenza H5N1 virus (HPAI H5N1) originated in Guangdong Province, China in 1996, which was followed by global dissemination of the virus that began in 2003. This virus is unprecedented in geographical spread, economic consequences and public health …
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QCM Aptasensor for Rapid and Specific Detection of Avian Influenza Virus
… rapid detection of avian influenza virus (AIV) H5N1 due to it being a potential pandemic threat. Most of the current methods, including culture isolation and PCR, are very sensitive and specific but require specialized laboratories and trained personnel in order to complete the tests and are …
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Investigating the spread of emerging Avian Influenza viruses using cross-disciplinary and computational approaches
… prevalence of two potentially pandemic strains (H5N1 and H7N9) in avian populations through a meta-analysis. In chapters 3, 5 and 6, spatial data was used to identify locations of highest disease incidence, predict areas at risk of disease incursions, and identify factors driving disease spread. …
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Host Modulators of the Death Response to Influenza A Infection
… inhibition of RGGT partially protected against H5N1 and the 2009 H1N1 pandemic strain. The observations reported here thus contribute to decoding vulnerabilities in the command and control networks specified by influenza virulence factors.
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Harnessing In Silico platform for Vaccine Discovery, Disease Modeling, and Immunotoxicity Prediction in Pandemic and Emergency Scenarios
… multi-epitopico contro il ceppo influenzale H5N1, utilizzando la vaccinologia inversa, un approccio computazionale che consente una rapida identificazione degli antigeni. La ricerca si estende anche alla progettazione di vaccini più ampi per l’influenza stagionale, migliorando la protezione …
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Entwicklung influenzabindender Peptide für die Biosensorik
… verschiedener Serotypen (z.B. H1N1/2009, H5N1/2004, H7N1/2013). Schließlich konnte durch Verwendung einer in der Primärsequenz angepassten höher affinen Peptidvariante die Influenzainfektion in vitro inhibiert werden. Damit stellen die vom ursprünglichen Peptid PeB abgeleiteten Varianten …
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Cytokine-bearing Influenza Vaccine: Adjuvant Potential of Membrane-bound Immunomodulators
… ominous threat of an avian influenza pandemic (H5N1), demonstrates the need for a much improved, more sophisticated influenza vaccine. Our group has developed an in vitro model system for producing a membrane-bound Cytokine-bearing Influenza Vaccine (CYT-IVAC). Numerous cytokines are involved in …
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Human adaptation of avian influenza viruses
… particular importance are strains belonging to H5N1, H7N7, H7N2 and H9N2 subtypes that continue to circulate in birds worldwide and have on occasions caused infections in humans. A key step in influenza human adaptation is the accumulation of substitutions/mutations in the viral coat …
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Epidemiology and risk factor analysis of avian influenza virus
… common subtype reported in these outbreaks was H5N1 (38.2%), while almost 82.5% of the subtypes were highly pathogenic avian influenza viruses. There were differences noticed between ProMED mail and the scientific literature screened. The Sentinel surveillance system was used to analyze …
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In Silico Platform for Accelerated Drug and Vaccine Development, Assessment, and Repositioning in Pandemic and Emergency Scenarios [Piattaforma In Silico per lo Sviluppo Accelerato, la Valutazione e il Riposizionamento di Farmaci e Vaccini in Scenari di Pandemia ed Emergenza]
… in particolare i ceppi aviari come l'H5N1, rappresenta un rischio considerevole a causa dell'elevato tasso di mutazione e della capacità di “spillover” zoonotico. La rapida diffusione globale del COVID-19 ha dimostrato la necessità di una preparazione completa contro pandemie simili …
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Glycan receptor binding determinants of Influenza A virus hemagglutinin
… influenza subtypes (H1N1, H2N2, H3N2 and H5N1) are studied using a combination of approaches including dose-dependent glycan binding, human tissue staining and structural modeling. Using these complementary analyses, it is shown in this thesis that the molecular interactions between amino …
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Interferences between non-proliferation and science: ‘exporting’ dual-use know-how and technology in conformity with security imperatives
… and terms discussed all over the study. The H5N1 case study brings to the fore the differences between the EU and US in the oversight of dual-use research. Chapter 5 presents an assessment of the US trade controls towards academia. How do the US authorities interpret the fundamental research …
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Decoding structure-function relationships of glycans
… required, and potential mutational paths, for H5N1 to quantitatively switch it's binding specificity to human glycans receptors, ii) identify the mutations that enable the 2013 outbreak H7N9 HA to improve binding to human glycan receptors in the upper respiratory tract, iii) uncover H3N2 …
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Studies on severe acute respiratory syndrome coronavirus type -2 in Northern South Africa
… nationwide by the NICD. Specifically, IAV (H5N1)/Guandong, a highly pathogenic influenza virus, was detected, although at a low frequency. Discussion and Conclusion: The systematic review revealed that despite the outbreaks of SARS in Southeast Asia in 2002 and MERS in 2012 in the Middle …