Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"H3N2"”.
-
The biophysical evolution of human influenza H3N2 neuraminidase
The student, ChuYun Teo, submitted this Thesis for approval on 2022-04-05 at 15:02.
-
Determinants in the pandemic H3N2 influenza A virus hemagglutinin that affect receptor binding and transmission in the pig
… Hiertoe werd gebruik gemaakt van het H3N2 1968 pandemisch influenzavirus (R1-HK) en recombinante precursors met 2 (R2-HK) of 5 (R5-HK) mutaties in het hemagglutinine.
-
Influenza Dynamics from Pre-pandemic to Post-pandemic Periods: Epidemiology and Genetic Characteristics
… 2022, focusing on whole genome sequencing of A/H3N2 viruses (predominant subtype circulating in this season). Phylogenetic analysis demonstrated the evolution of A/H3N2 viruses, and a reduction in their genetic subclade diversity compared to the pre-pandemic season. Whole-genome analysis also …
-
Influenza A Virus PB1-F2 Protein: its Role in Pathogenesis
… largely unknown. In the triple-reassortant H3N2 (TR H3N2) swine influenza virus (SIV) background, we found that PB1-F2 expression did not affect nasal shedding, lung viral load, immunophenotypes, and lung pathology in pigs. On the other hand, in turkeys, deletion of PB1-F2 resulted in early …
-
FMF assay for assessing vaccine generated antibodies in a biomimetic manner
… Rico/8/1934 and A/Brisbane/59/2007), and H3N2 virus (A/Aichi/68) with their respective subtype specific stem specific monoclonal antibodies: M145, Aca-1, Aca-2 (H1N1 specific) and Aca-3 (H3N2 specific). Subtype specific mAbs blocked membrane fusion, while a mismatch in virus subtype and …
-
Entwicklung influenzabindender Peptide für die Biosensorik
… in der Lage sind, Influenzaviren vom Stamm X31 (H3N2 A/Aichi/2/1968) zu binden. Die Interaktion des Peptids PeB, welches potentiell mit der konservierten Rezeptorbindestelle im HA interagiert, wurde anschließend näher charakterisiert. Die Detektion der Influenzaviren war unter geeigneten …
-
Spectral analysis of neutral evolution
… over the neutral networks of H1N1 and H3N2 influenza haemagglutinin during seasons between 2005 and 2016. It is shown that, in some instances, these populations experience an exploration catastrophe. These results provide insight into the behaviour of populations on neutral networks, …
-
Visualisation and analysis of patterns in serological data using "antibody landscapes"
… on antibody-mediated immunity against the A/H3N2 influenza subtype. Applying the methodology to study annual serum samples from individuals monitored for influenza infection over a period of six years, patterns of influenza immunity were found to be remarkably distinct and maintained almost …
-
Dissecting Human Antibody Responses Against Influenza A Viruses And Antigenic Changes That Facilitate Immune Escape
… antibody responses. We next demonstrate that an H3N2 HA substitution introducing a glycosylation site prevents the binding of neutralizing antibodies present in a large number of individuals. Importantly, our egg-based vaccines lack this glycosylation due to culture-adaptive substitutions, but a …
-
The role of RNA structures in the evolution of respiratory RNA virus genomes.
… potential, are changing during pandemic IAV H3N2 evolution. Using in silico analyses, I observed a decline in RNA structure stability in the polymerase segments over time. Control analyses showed that this change was independent to amino acid mutation and reduced in human-adapted viruses, but …
-
Étude du clivage de l'hémagglutinine de l'influenza par la matriptase
… de virus H1N1 mais pas celle de virus H3N2 dans des modèles cellulaires d'épithélium bronchique. La microscopie confocale a également montré la colocalisation du virus de l’influenza avec la matriptase dans les endosomes lors de l’entrée du virus dans la cellule. L'utilisation de la …
-
Can Plant Plastid Produce a Candidate Influenza Vaccine?
… attempts to express HA from the A/Sichuan/2/87 H3N2 influenza subtype in plastids achieved HA gene transcription but no protein accumulation, suggesting that the HA protein may be unstable in the plastid. The aim of this work is to investigate alternative strategies that might achieve HA antigen …
-
Glycan receptor binding determinants of Influenza A virus hemagglutinin
… from different influenza subtypes (H1N1, H2N2, H3N2 and H5N1) are studied using a combination of approaches including dose-dependent glycan binding, human tissue staining and structural modeling. Using these complementary analyses, it is shown in this thesis that the molecular interactions …
-
Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… mutant doc/doc mice exposed sequentially to H3N2 and H1N1 influenza viruses formed normal numbers of memory CD8 T cells binding H2-Db MHC tetramers bearing the dominant influenza NP peptide epitope, NP366-374 (NP+), in contrast to Dock8 mutant mice analysed in parallel which had greatly …
-
Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… mutant doc/doc mice exposed sequentially to H3N2 and H1N1 influenza viruses formed normal numbers of memory CD8 T cells binding H2-Db MHC tetramers bearing the dominant influenza NP peptide epitope, NP366-374 (NP+), in contrast to Dock8 mutant mice analysed in parallel which had greatly …
-
Zeolites Structure, Influenza Evolution and Vaccine Effectiveness, with Prediction of Emerging Flu Strain Clusters
… and report the most current results for pandemic H3N2 flu vaccine design. A 2006 model of dimensional reduction (compaction) of viral mutational complexity derives two-dimensional Cartesian mutational maps (2DMM) that exhibit an emergent dominant strain as a small and distinct cluster of as few as …
-
Dynamic factor analysis with dependent Gaussian processes for high-dimensional biomarker trajectories
… simulations and application to a real-world H3N2 dataset. To fit the model, we propose a Monte Carlo expectation maximization (MCEM) scheme that can be implemented conveniently by combining a standard Markov Chain Monte Carlo sampler and an R package GPFDA, which returns the maximum …
-
Influenza a virus gene expression heterogeneity regulates viral superinfection potential and host innate antiviral response
… response to infection. Finally, human H1N1 and H3N2 virus infections differ significantly in patterns of host anti-viral gene transcriptional at single cell level. These results revealed that how patterns of viral gene expression heterogeneity can serve as a major determinant of host antiviral …
-
How codon choice determines evolvability and evolutionary robustness in short linear motifs
… motif emergence. For influenza strains H1N1 and H3N2, which were introduced in the human population from birds during the 1900s, the sequence of the early strains could be used to predict the majority of the glycosylation sites that would emerge the following decades. The predictability of motif …
Page 1 of 2