Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"H3K9me2"”.
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Investigating the role of histone H3 lysine 9 dimethylation in regulating disease-associated vascular smooth muscle cell gene expression
… the role of histone 3 lysine 9 dimethylation (H3K9me2), a repressive epigenetic mark, in regulating the expression of disease-associated VSMC genes. Intriguingly, murine models of VSMC phenotypic switching revealed reduced levels of H3K9me2 upon loss of the contractile state while chromatin …
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Characterization of interplay among DNA repair, histone H3 lysine 9 dimethylation and small interfering RNA pathway in Caenorhabditis elegans
… species. Histone H3 lysine 9 dimethylation (H3K9me2) has been shown to play an important role in mediating the formation of heterochromatin. In our lab, we use Caenorhabditis elegans as a model system to study the biological significance of the enrichment of H3K9me2 on repetitive elements and …
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MET-2 and SET-25 have sexually dimorphic effects on chromosome structure in Caenorhabditis elegans
… converting histone H3 lysine 9 dimethylation (H3K9me2) to trimethylation (H3K9me3), reduces the bivalent length in oocytes. On the other hand, a mutation of met-2, a histone methyltransferase depositing H3K9me2 in the germ line decreases the bivalent length in spermatocytes. Although bivalent …
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The role of Arabidopsis thaliana heterochromatin component H2A.W in meiotic recombination
… and specific chromatin modifications, including H3K9me2 and DNA methylation. Analysis of histone H2A variants via ChIP-sequencing has revealed that H2A.W is enriched in the heterochromatin. By combining cytogenetic, genetic and genomic assays, I have demonstrated that HTA7 is specifically …
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STUDY OF EPIGENETIC REGULATORS AND SIGNATURES OF AGING
… oxidative DNA damage allows the maintenance of H3K9me2-enriched heterochromatin, which represses the activation of specific retrotransposons during aging. Therefore, by regulating transcription of Hsp genes in the brains, NELF-A controls multiple aspects of aging in Drosophila.
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A genetic interaction network of constitutive heterochromatin in Caenorhabditis elegans
… are marked by histone H3 lysine 9 dimethylation (H3K9me2), consistent with direct repression, whereas deregulation of the metabolic and stress response pathway genes appears indirect as their promoters generally lack H3K9me2. I investigated the mechanisms by which genetic suppressors rescue the …
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The Epigenetics of Small Cell Prostate Cancer
… in silencing histone modifications (H3K27me3 and H3K9me2) and that EZH2 inhibition with DZNep results in AR re-expression and growth inhibition in AR<sup>-</sup>SCPC cell lines. These data support the hypothesis that AR<sup>-</sup>SCPC are epigenetically distinct from AR<sup>+</sup>ADENO tumors …
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Quiescence induces epigenetic changes in bovine fibroblasts and improves their reprogramming into cloned embryos
… (K) of histone 3 (H3), specifically H3K4me3, H3K9me2, H3K9me3 and H3K27me3, but not H3K9me1. Histone acetylation was reduced at H3K9 and H4K5, increased at H3K12 and remained unchanged at H3K16. G₀ cells also significantly reduced DNAme. In addition, they significantly down-regulated the …
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Dynamic regulation of DNA demethylation and RNA-directed DNA methylation in Arabidopsis
… and H3K27me3, and with depletion of H3K27me1 and H3K9me2. Also we found that ROS1 can prevent the spreading of DNA methylation from highly methylated transposons to their nearby genes. Unexpectedly, we uncovered thousands of previously unidentified RdDM (RNA-directed DNA methylation) targets by …
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Characterisation of HP1γ in mammalian cells
… by binding to the repressive chromatin marks H3K9me2/3 with their chromodomains (CDs). Despite high sequence conservation, each HP1 paralogue possesses specific functions, which are likely to be cell type specific. The aim of my thesis was to find novel functions for HP1γ in mouse embryonic …
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Evolução cromossômica, disploidia e epigenética no gênero Phaseolus L. (Fabaceae)
… às regiões eucromáticas, enquanto H3K27me1, H3K9me2 (mono- e dimetilação das lisinas 27 e 9, respectivamente) e 5mC (5-metilcitosina) às heterocromáticas. Sítios de DNAr 45S, regiões centroméricas e a maioria dos blocos heterocromáticos terminais foram hipometilados, incluindo um associado a …
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The Role of Epigenetics in the Regulation of Meiotic Recombination in Triticum aestivum and Arabidopsis thaliana
… high levels of heterochromatic features such as H3K9me2, DNA methylation, and nucleosome density. In plant species, maintenance of heterochromatin is controlled via the concerted efforts CHROMOMETHYLASE 3 (CMT3) and KRYPTONITE/SUVH5/SUVH6 (KSS), and mutation of these features can remodel …
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Relationships between chromatin features and genome regulation
… - HPL-2/HP1, LIN-13, LIN-61, LET-418/Mi-2, and H3K9me2 histone methyltransferase MET-2/SETDB1 - collaborates with piRNA and nuclear RNAi pathways to silence repetitive elements and protect the germline. I also found that the TACBGTA motif is particularly enriched on repeats and heterochromatin …
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Mechanisms and functional significance of nuclear compartmentalization
… kilobases surrounding HBB and on G9a-mediated H3K9me2 methylation over flanking sequences in an adjacent Lamin Associated Domain. Our results demonstrate multiple cis elements regulate the overall balance of specific epigenetic marks and peripheral gene targeting.
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Control of Cardiac Remodelling during Ageing and Disease by Epigenetic Modifications and Modifiers
… euchromatic lysine 9 dimethylation on histone 3 (H3K9me2) as a conserved feature of pathological hypertrophy and associated with re-expression of foetal genes. Concurrently, expression and activity of the enzymes responsible for depositing H3K9me2, euchromatic histone lysine methyltransferases 1 …
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Role of ORCA and ORC in chromatin organization and DNA replication
… methyl transferases including G9a, GLP, Suv39h1 (H3K9me2/3), Suv420h1/h2 (H4K20me2/3) and EZH2 (H3K27me3). Removal of ORCA from human cells causes aberrations in the chromatin architecture. I therefore propose that ORCA acts as a scaffold protein that enables the formation of multiple histone …