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Showing 1 to 20 of 25 for “"H3K9"”.

  1. Soft 3D fibrin matrices downregulate FAK expression to promote self-renewal of tumor-repopulating cells

    Wood, Adam RichardUniversity of Illinois at Urbana-Champaign2015

    … in TRCs by promoting histone 3 lysine residue 9 (H3K9) de-methylation and Sox2 expression [1]. However, the underlying mechanism(s) by which soft 3D fibrin matrices promote H3K9 de-methylation and Sox2 expression remain elusive. In this study we show that focal adhesion kinase (FAK) regulates Sox2 …

    uiuc Repository record

  2. Studies on the Histone Methyltransferase G9a

    Sampath, Srihari Cidambi

    … the possible functions of histone 3, lysine 3 (H3K9) methylation in the immune system through conditional inactivation of the H3K9-specific methyltransferases G9a and GLP. These studies demonstrate that G9a is essential for B cell development in the mouse, but is dispensable for T cell …

    rockefeller Repository record

  3. Neuroglial Mechanisms Involved In The Anti-Inflammatory Effect Of Acetate Supplementation

    Soliman, Mahmoud Lotfy

    … and reversed LPS-induced histone H3 at lysine 9 (H3K9) hypoacetylation and interleukin (IL)-1β expression. In LPS-stimulated BV-2 microglia, acetate treatment reversed LPS-induced H3K9 hypoacetylation, IL-1β, IL-6, tumor necrosis factor (TNF)-α, cyclooxygenase (Cox)-1 and 2 protein levels, and …

    nodak Repository record

  4. The synthetic multivulva genes and their suppressors regulate opposing cell fates through chromatin remodeling

    Andersen, Erik CMassachusetts Institute of Technology2008

    … which deacetylates lysine nine of histone H3 (H3K9), and HP1, we found two histone methyltransferase (HMT) genes (met-1 and met-2) that act as class B synMuv genes and repress lin-3 transcription. met-1 encodes a C. elegans homolog of yeast Set2, an H3K36 HMT that inhibits the ectopic …

    mit Repository record

  5. Role of ORCA and ORC in chromatin organization and DNA replication

    Giri, SumanpravaUniversity of Illinois at Urbana-Champaign2016

    … with heterochromatin. ORCA recognizes methylated H3K9 marks and interacts with repressive KMTs, including G9a/GLP and Suv39H1 in a chromatin context-dependent manner. Single-molecule pull-down assays demonstrate that ORCA-ORC and multiple H3K9 KMTs exist in a single complex and that ORCA …

    uiuc Repository record

  6. Molekulare und funktionelle Analyse von Windei (CG12340) als Bindungspartner der Histonmethyltransferase Eggless während der Oogenese von <i>Drosophila</i>

    Koch, Carmen2012

    … Die Trimethylierung von Histon 3 am Lysin 9 (H3K9me3) führt zur Ruhigstellung des Chromatins und zur Bildung von Heterochromatin durch die Rekrutierung von Heterochromatin Protein 1 (HP1). Eggless (Egg), das Ortholog der humanen Methyltransferase SETDB1, ist für die H3K9-Trimethylierung in der …

    goettingen Repository record

  7. Characterization of Chronic Glucocorticoid Exposure on Natural Killer Cell Function: A Model for Stress Induced Alterations on the Epigenetic Landscape

    Eddy, Justin Lee1970

    … 2 (HDAC2) with concomitant reduction in H3K9-acetylation (Ac). In contrast, IL-6 and IFN-g were primed for increased transcription upon cellular activation demonstrating increased H4K8Ac, increased accessibility of the chromatin structure, and concomitant loss of HDAC1 and HDAC3 at …

    loyola-thes Repository record

  8. Stochastic Activation of Enhancers in the Innate Immune Response by the Histone Demethylase JMJD2D

    Chandwani, Rohit

    … I interferon responses. siRNA-depletion of the H3K9 demethylase JMJD2d attenuates gene activation and overexpression of JMJD2d potentiates the IFN response. We find that the underlying mechanism involves the activation of enhancers – knockdown of JMJD2d attenuates stimulus-induced enhancer …

    rockefeller Repository record

  9. Using S. pombe to Study the Biological Roles of the Histone Deacetylases Sir2 and Clr3 and the DEAD-Box RNA Helicase Ded1

    Lowe, Brandon Ray2018

    … well as methylation of histone H3 on lysine 9 (H3K9me). Heterochromatin assembly can now be separated into three distinct steps: heterochromatin establishment, spreading, and maintenance. These steps involve the actions of the histone H3K9 methyltransferase Clr4 along with the RNAi pathway. …

    tenn-hsc Repository record

  10. The Novel Regulation of Histone Modification In Cancer Development

    zhang, xian2017

    … reveals that NEDD4 regulates glucose-induced H3K9 acetylation at transcription starting site (TSS) and enhancer regions. Integrative analysis of ChIP-seq and microarray data sets also reveals a consistent role of H3 ubiquitination in transcription activation and H3 K9 acetylation in response …

    uthsc Repository record

  11. Transposable elements and the regulatory logic of hematopoietic differentiation

    Najia, Mohamad AliMassachusetts Institute of Technology2023

    … differentiation. Specifically, knockout of the H3K9 methyltransferase EHMT1 or transcriptional co-repressor TRIM28 induced NK-fated progenitors that ultimately generated NK cells with diverse effector properties. We further leveraged TEs by repurposing the packaging function of the MLV gag …

    mit Repository record

  12. Investigating 3D genome organisation in Caenorhabditis elegans with Accessible Region Conformation Capture (ARC-C)

    Seow, Wei QiangUniversity of Cambridge2019

    … Bristol N2, met-2 set-25 mutants that have no H3K9 methylation to study the effects on domain and compartment formation. In these mutants, compartmentalisation (i.e. inter-domain interactions) between H3K27me3-enriched regulated domains is reduced. I also used ARC-C in blmp-1 mutants to …

    cambridge Repository record

  13. Quiescence induces epigenetic changes in bovine fibroblasts and improves their reprogramming into cloned embryos

    Kallingappa, Prasanna KumarUniversity of Waikato2013

    … (K) of histone 3 (H3), specifically H3K4me3, H3K9me2, H3K9me3 and H3K27me3, but not H3K9me1. Histone acetylation was reduced at H3K9 and H4K5, increased at H3K12 and remained unchanged at H3K16. G₀ cells also significantly reduced DNAme. In addition, they significantly down-regulated the …

    waikato-masters Repository record

  14. Investigating the molecular dynamics of gene re-silencing following treatment with epigenetic therapies

    Patil, VibhaUNSW, Sydney2015

    … the persistence of the repressive histone mark H3K9me3 following 5-Aza-dC treatment we find that, in this model, inhibitors of H3K9 methyltransferases do not delay gene re-silencing. These findings show that gene re-silencing is not driven by DNA re-methylation but involves other mechanisms, …

    unsw Repository record

  15. Determinants of piRNA precursor transcription and export in Drosophila melanogaster

    Kneuss, EmmaUniversity of Cambridge2021

    … been shown to bind to the heterochromatic mark H3K9me3 at piRNA clusters, the determinants that specify the exclusive association of RDC with dual-strand clusters remained largely unknown. For the first part of this thesis, I performed a genetic screen in Drosophila germ cells to identify …

    cambridge Repository record

  16. REGULATION OF TELOMERASE EXPRESSION IN STEM CELL REPROGRAMMING

    Sachs, Patrick2015

    … demonstrated a lack of an acetylated histone H3K9 with the opposing di-methylation, indicative of a closed chromatin state at the hTERT promoter. Subsequent treatment of cells with TSA alone showed an upregulation of hTERT mRNA without telomerase activity. However, telomerase activity was …

    vcu Repository record

  17. Regulation of Chromosome Segregation by the Chromosomal Passenger Complex

    Tseng, Boo Shan

    … from its stably methylated histone H3 lysine 9 (H3K9) chromatin binding site, clearly demonstrating the existence of a "methyl/phos switch." While the significance of this chromosomal HP1 removal is unclear, I propose that it functions in proper M-phase chromosome compaction. In eukaryotes, …

    rockefeller Repository record

  18. Pharmacological Inhibition of LSD1/KDM1A in Diffuse Midline Glioma Models and Impact on Kinase Signaling

    Hernandez, Faith Angelina, <h2>0009-0004-0039-4537</h2> <p>content_copyprint expand_lessShow record summary</p>2024

    … mono- and di-methyl marks on H3K4 and H3K9 residues. This demethylase activity can impact gene transcription and overall gene expression, where dysregulated LSD1 expression has been found to be implicated in tumorigenesis highlighting LSD1 as a possible therapeutic target. Our lab’s …

    uthsc Repository record

  19. HISTONE POSTTRANSLATIONAL MODIFICATIONS AND GENE EXPRESSION IN SACCHAROMYCES CEREVISIAE

    Shukla, Abhijit2009

    … far, histone H3 acetylation at lysines 9 and 14 (H3K9/14), monoubiquitination of histone H2B at lysine123 (H2BK123) and H3 lysine 4 methylation (H3K4) are among the more studied ones. The importances of these modifications have been further stressed by its connection to various human diseases …

    siu-theses Repository record

  20. Mechanisms and functional significance of nuclear compartmentalization

    Khanna, NimishUniversity of Illinois at Urbana-Champaign2015

    … to the nuclear periphery and confer increased H3K9me3 modification, as assayed both by immunofluorescence and chromatin immunoprecipitation. PTRs within HBB BACs bias a competition between peripheral versus pericentric heterochromatin (PCH) targeting towards peripheral targeting. Targeting to …

    uiuc Repository record

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