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Showing 1 to 6 of 6 for “"H3K79 methylation"”.
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Mechanistic Insights into Direct Interactions that Mediate the Activity of DOT1L Complex in MLL-Rearranged Leukemia
… 1-like) complex. Aberrant histone H3 Lysine 79 (H3K79) methylation catalyzed by DOT1L was shown to be crucial for the maintenance of MLL-rearranged leukemia. DOT1L is the only known H3K79 methyltransferase, and further, a DOT1L inhibitor is currently being evaluated in clinical trials to treat …
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Identification of a Functional Hotspot on Ubiquitin Required for Stimulation of Methyltransferase Activity on Chromatin
… responsible for the regulation of H3K4 and H3K79 methylations, through the direct stimulation of methyltransferase activity specific to the installation of these marks. Interested in the surface features on ubiquitin required for H2B-Ub stimulation of the human H3K79 methyltransferase, …
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Implications of a CALM-derived Nuclear Export Signal for CALM-AF10-mediated Leukemogenesis
… are hypermethylated on Histone H3 lysine 79 (H3K79), which corresponds with their transcriptional upregulation. Conversely, <italic>CALM-AF10</italic> cells display global H3K79 hypomethylation. DOT1L, the H3K79 histone methyltransferase, interacts with the OM-LZ domain of AF10, and the AF10 …
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Mechanistic Insights into the Stimulation of Dot1L-Mediated Methylation of Histone H3 by Semisynthetically Ubiquitylated Histone H2b
… 120 (uH2B), has been correlated with enhanced methylation of lysine 79 (K79) of histone H3 by K79-specific methyltransferase, disruptor of telomeric silencing-like (Dot1L/KMT4). However, the specific function of uH2B in this crosstalk pathway was not understood, in part due to the challenges …
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The critical role of histone methylation in tumour progression and as anti-cancer targets in neuroblastoma
… of target oncogenes. Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisites for Myc-induced transcriptional activation. DOT1L is the only known histone methyltransferase that catalyses mono-methylation (me), di-methylation (me2) …
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Significance of Protein Interactions in Mediating AF9 Function
… Dot1l. It has been shown that Af9-Dot1l promotes H3K79 methylation at specific sites in the ENaCα promoter, which then contributes to its repressed state. A number of reports have described the direct or indirect association of</p><p>the C-terminus of AF9 with several distinct proteins including …