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Showing 1 to 8 of 8 for “"H3K4 methylation"”.
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The Role of the Set1 RNA Polymerase II Interacting Motif (SRIM) in Set1 Recruitment and Histone H3K4 Methylation
… Among these modifications, histone H3 lysine 4 (H3K4) methylation has been associated with transcription activation. Set1 is the sole H3K4 histone methyltransferase in Saccharomyces cerevisiae and functions in a multi-subunit protein complex (Set1C) to catalyze H3K4 mono-, di-, and …
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HISTONE POSTTRANSLATIONAL MODIFICATIONS AND GENE EXPRESSION IN SACCHAROMYCES CEREVISIAE
… H2B at lysine123 (H2BK123) and H3 lysine 4 methylation (H3K4) are among the more studied ones. The importances of these modifications have been further stressed by its connection to various human diseases including cancers. Previous biochemical studies have shown that H2BK123 ubiquitination …
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Histone H3 K4 Methylation Regulates The Spindle Assembly Checkpoint Through Direct Binding of Multiple Checkpoint Components and Cdc20
<p>Histone H3K4 methylation is conserved across species and is associated with active transcription. By using <em>Saccharomyces cerevisiae</em>, we found histone H3K4 methylation has a previously unknown role in regulating mitosis through the Spindle Assembly Checkpoint. The Spindle Assembly …
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JMJC Domain-Containing Histone Demethylase 2 (Jhd2): Bridging the Gap between H3K4 Trimethylation and H3 Acetylation
… tail of histones. Among these modifications is methylation of lysine residues. The enzyme Jhd2 is a histone demethylase that functions to remove H3K4 methylation in S. cerevisiae. Jhd2 is a homologue of the human JARID1 family of histone demethylases, which has four members: JARID1A, B, C and D. …
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JMJC Domain-Containing Histone Demethylase 2 (Jhd2): Bridging the Gap between H3K4 Trimethylation and H3 Acetylation
… tail of histones. Among these modifications is methylation of lysine residues. The enzyme Jhd2 is a histone demethylase that functions to remove H3K4 methylation in S. cerevisiae. Jhd2 is a homologue of the human JARID1 family of histone demethylases, which has four members: JARID1A, B, C and D. …
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Regulation of Set1-Mediated Methylation of Dam1
… of posttranslational modifications including methylation, phosphorylation, and ubiquitination, which are integral to a range of DNA-templated processes including transcriptional regulation. A hallmark for transcriptional activity is methylation of histone H3 on lysine (K) 4 within active gene …
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Identification of a Functional Hotspot on Ubiquitin Required for Stimulation of Methyltransferase Activity on Chromatin
… additionally responsible for the regulation of H3K4 and H3K79 methylations, through the direct stimulation of methyltransferase activity specific to the installation of these marks. Interested in the surface features on ubiquitin required for H2B-Ub stimulation of the human H3K79 …
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Trim24-Regulated Estrogen Response Is Dependent On Specific Histone Modifications In Breast Cancer Cells
… unmethylated</p> <p>histone H3 lysine K4 (H3K4me0), is critical for ERα-regulated transcription.</p> <p>Therefore, when LSD1-mediated demethylation of H3K4 is inhibited, activation of</p> <p>TRIM24-regulated ERα target genes is greatly impaired. Importantly, I</p> <p>demonstrated that …