Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"H3K36me2"”.
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Molecular Characterization of Mammalian De Novo DNA Methyltransferase Chromatin Recruitment
… through PWWP reader domain recognition of H3K36me2, an abundant histone post-translational modification (PTM) in cells. Following depletion of cellular H3K36me2 levels, DNMT3A is re-targeted to actively transcribed gene bodies through PWWP domain interaction with H3K36me3, thereby …
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Paraspeckle protein NONO regulates active chromatin by allosterically stimulating NSD1
… SET Domain Protein (NSD) family for H3K36me2 and the Polycomb Repressive Complex 2 (PRC2) for H3K27me3. NSD1, in particular, plays a crucial role in maintaining euchromatin integrity, and its loss or aberrant activation has been implicated in human congenital disorders, such as Weaver …
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HISTONE LYSINE METHYLTRANSFERASE NSD3 GOVERNS TRANSCRIPTIONAL PROGRAMS THAT DRIVE PANCREATIC NEUROENDOCRINE TUMORS (PANNETS)
… PanNETs through di-methylation of histone H3K36 (H3K36me2).</p> <p>The findings shown in this body of work indicate that H3K36 methylation by NSD3 functions as a transcriptional activator accelerating tumorigenesis in PanNETs. Additionally, we established a novel genetically engineered mouse model …