Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"H3K36 methylation"”.
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HISTONE LYSINE METHYLTRANSFERASE NSD3 GOVERNS TRANSCRIPTIONAL PROGRAMS THAT DRIVE PANCREATIC NEUROENDOCRINE TUMORS (PANNETS)
… critical oncogenic driver of PanNETs through di-methylation of histone H3K36 (H3K36me2).</p> <p>The findings shown in this body of work indicate that H3K36 methylation by NSD3 functions as a transcriptional activator accelerating tumorigenesis in PanNETs. Additionally, we established a novel …
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The synthetic multivulva genes and their suppressors regulate opposing cell fates through chromatin remodeling
… encodes a C. elegans homolog of yeast Set2, an H3K36 HMT that inhibits the ectopic initiation of transcription, and met-2 encodes a homolog of human SETDB1, an H3K9 HMT involved in transcriptional repression. Our results link H3K36 methylation to a transcriptional repression cascade composed of …
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Regulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6
Histone H3 lysine 36 (H3K36) trimethylation is a conserved post-translational modification critical for maintaining eukaryotic transcriptional fidelity and genomic stability. This modification is catalyzed in yeast by Set2, an ortholog of the mammalian H3K36 methyltransferase SETD2. Several studies …
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On the epigenetic ageing clock in humans
… the biological age of an organism using DNA methylation data, and which have emerged in the last few years as the most accurate biomarkers of the ageing process. However, little is known about the molecular mechanisms that control the rate of such clocks. In this thesis I focus on the study …