Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"H3K27me3"”.
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INVESTIGATING EPIGENETIC MECHANISMS OF CHEMORESISTANCE IN OVARIAN CANCER: THE ROLE OF H3K27ME3
… outcomes. This analysis revealed reduced H3K27me3 level in patients displaying short-term survival (< 2 years after diagnosis) and associated with an increased tumour resistance to chemotherapy, compared to Long-Term Survivors (LTS) (> 10 years after diagnosis), with an improved …
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Molecular targets of chromatin marks H3K4ME3, H3K9ME3 and H3K27ME3 in an adult germinal niche
… histone modifications: H3K4me3, H3K9me3 and H3K27me3. Our data suggest these chromatin marks are associated with genes responsible for cellular organization and morphology, proliferation and survival, neuron development. Taken together these processes suggest histone modifications, …
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TOWARD STRUCTURAL INSIGHTS INTO THE RECOGNITION OF H3K27 TRIMETHYLATION BY CANONICAL PRC1
… to PRC2 target sites through the recognition of H3K27me3 by the CBX chromodomain, while variant PRC1 complexes are defined for the presence of RYBP instead of CBX and their chromatin recruitment is independent of PRC2 localization and activity. Although the enzymatic function of PRC1 has been …
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The role of Polycomb-mediated epigenetic regulation in embryonic stem cell differentiation
… the posttranslational histone modification H3K27me3, a histone modification associated with transcriptional repression. Although PRC2 has critical functions in lineage commitment and in mediating cell fate transitions, it has proved difficult to study its precise role in these processes …
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THE IMPACT OF REPLICATION STRESS ON THE EPIGENOME OF MOUSE EMBRYONIC STEM CELLS
… active histone marks revealed a global loss of H3K27me3 and the maintenance of H3K4me3 at gene promoters following aphidicolin-induced replication stress. Notably, the activation of a subset of bivalent developmental genes – marked by both H3K27me3 and H3K4me3 – was associated with …
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Regulation of Chromatin Landscape on and by the Human Sex Chromosomes
… and Xi-silent genes, we quantified H3K4me3, H3K27me3, and CTCF along Xi by linear modeling in cells of individuals with zero to three Xis. We demonstrate that Xi-expressed genes are enriched for H3K4me3 compared to Xi-silent genes. Moreover, Xi-silent genes near strongly Xi-expressed genes …
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Postmitotic Dynamics in Chromatin Modification and Regulatory Topology Underlie Cerebellar Granule Maturation
… of histone H3 lysine 27 trimethylation (H3K27me3), demonstrating a causal function for this chromatin modification in gene regulation beyond its canonical role in cell fate specification. The developmental loss of H3K27me3 at promoters of genes that turn on as CGNs mature is facilitated …
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CRAMP1 drives linker histone expression to enable Polycomb repression
… which results in selective decompaction of H3K27me3-marked loci and derepression of PRC2 target genes without concomitant loss of PRC2 occupancy or enzymatic activity. Strikingly, in contrast to the broad genomic distribution previously ascribed to H1, I find that linker histones selectively …
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CHD Chromatin Remodelers Promote Epigenetic Control of Development in Arabidopsis thaliana
… in vivo and promotes the epigenetic modification H3K27me3, which is associated with transcriptional repression of tissue-specific genes by the PRC2. Thus, PKL plays an important role in promoting tissue identity by facilitating deposition and/or maintenance of H3K27me3.
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Regulation of polycomb repressive complexes at the neural differentiation gene Pax6
… machinery that deposit the histone modifications H3K27me3 and H2AK119Ub at target genes and were shown to impose chromatin compaction. To test the possibility of FGF/ERK regulated polycomb mediated chromatin compaction at neural differentiation gene loci in the stem zone/ caudal lateral epiblast a …
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Investigating the role of DPPA2 and DPPA4 in the Epigenetic Control of Lineage Programs in Human Embryonic Stem Cells
… active and repressive modifications, such as H3K27me3, H3K4me3 and H3K4me1. Combining opposing modifications may help to maintain robustness of genes to low levels of signal, whilst retaining the capacity to respond upon the appropriate level. Despite their importance in controlling cell fate …
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Does Epigenetic Silencing Affect Skeletal Muscle Angiogenesis?
… mice, 9 weeks of endurance training increased H3K27me3 protein global abundance. With an acute bout of exercise in 14 days trained, H3K27me3 decreased. Angiogenic gene Kdr mRNA expression decreased after 9 weeks of endurance training. Overall, exercise protocols affect the histone modifications …
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Analysis of CHD Remodelers during Development: A Tale in Two Organisms
… organisms. I show that PICKLE not only promotes H3K27me3 during development to repress developmental genes but also is targeted to these genes. The association of PICKLE to these genes suggests that both repression and H3K27me3 levels is a direct action of PICKLE on these loci. Using zebrafish as …
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Zika Modulates Arthropod Histone Methylation in Mosquito Cells
… gene transcripts and histone tri-methylation (H3K27me3) were noted in ZIKV-infected C6/36 cells in comparison to uninfected controls. Exogenous treatment with SAMe showed significant increased viral burden and expression of EZH2 transcripts in ZIKV-infected C6/36 cells at day 1 p.i. in …
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Μοριακά δίκτυα δυνητικών stem κυττάρων στο κακόηθες μελάνωμα του δέρματος
… ή με ανενεργή κατάσταση της χρωματίνης (H3K27me3), ενώ η απορρύθμιση των επιγενετικών μηχανισμών ελέγχου σε συγκεκριμένους γονιδιακούς τόπους έχει συσχετισθεί με τη καρκινογένεση στον άνθρωπο. Σημαντικό ρόλο στη ρύθμιση αυτών των bivalent domain φαίνεται να έχουν οι πρωτεΐνες της …
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Xenoestrogen-Specific Mechanisms of Developmental Reprogramming Correlate With Gene Expression and Tumor Development
… of EZH2 by AKT reduces the levels of H3K27me3 in vitro and in vivo, this work demonstrates in vivo that a brief neonatal exposure to GEN, in contrast to BPA, activates the PI3K/AKT pathway to regulate EZH2 and decreases H3K27me3 levels in the neonatal uterus. Given that H3K27me3 is a …
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Dynamic histone modifications at the promoters of Hox genes in embryonic stem cells
… Contrastingly, the repressive modification H3K27me3 was found at equivalent levels across the cluster. Treatment with the histone deacetylase inhibitor valproate induced a coordinate increase in the levels of H3K9ac and H3K4me3 at all Hoxb promoters, but not other genes, whilst H3K27me3 was …
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The role of heterochromatin markers in lytic human herpesvirus egress and maturation
… at the 9th and 27th lysine residue (H3K9me3 and H3K27me3 respectively) and histone variant macroH2A are common markers of heterochromatin. Over the course of lytic herpesvirus infection, host chromatin undergoes extensive gross remodeling as chromatin is marginalized to the nuclear periphery to …
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Epigenetic Modification as a Therapeutic Target in BRAFV600E-mutated Metastatic Colorectal Cancer
… elevation of the repressive histone methylation, H3K27me3, leading to compensatory suppression of key tumor suppressor genes, including Wnt pathway genes. EZH2 inhibitors targeting H3K27me3 additively sensitized DNMT inhibitors in BRAF<sup>V600E</sup> CRC. Additionally, the combination of …
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The chromatin landscape of barley: gene expression, evolution and epigenetics
… except histone H3 lysine-27 tri-methylation (H3K27me3). In addition, chromatin states representing local chromatin environments were defined in the barley genome using the peak sharing data. Mapping the states onto the genome revealed a striking chromatin structure of the gene-rich chromosome …
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