Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"H3F3A"”.
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Characterisation of genetic and epigenetic aberrations in paediatric high grade glioma
… (94%) and 8p11.23-p11.22 (59%), respectively. H3F3A (K27M) mutation was present in 2/17 (12%) cases and concurrent loss of CDKN2A and BRAFV600E in 1/17 (6%) case. Genes involved in reelin/PI3K signaling (DAB1), RTK signaling (PTPRE), and arginine biosynthesis (ASS1 and ASL) were frequently …
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Genomic and Molecular Characterization of Brainstem Glioma
… of tumors within H3-Pons and H3-Medulla harbored H3F3A mutations, but showed distinct methy- lation patterns that correlated with anatomical localization of these tumors within the pons or medulla, respectively. Clinical data also showed significantly different overall survival between these …
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Comprehensive Integrated Genomic and Histopathological Analysis of Paediatric Diffuse Intrinsic Pontine Glioma
Diffuse intrinsic pontine glioma (DIPG) is a devastating, inoperable paediatric brain neoplasm with no effective therapy and near 100% fatality. Diagnosis is based mainly on radiological findings and numerous clinical trials using adjuvant chemotherapy over the last four decades have not shown a …