Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"H3.1"”.
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Structural Insights into the Mechanisms Controlling the Modification and the Readout of Histone H3.1
The histone H3.1 is the canonical histone H3 inserted into new nucleosomes during replication. The unstructured N-terminal region (also referred to as the tail) of histone H3.1 is decorated by many post-translational modifications (PTMs). These PTMs serve as epigenetic signals coordinating …
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Roles and Mechanisms of H3.1K27me1 Methyltransferases in Defense Against Virus in Arabidopsis
… Protein 5 (ATXR5) and ATXR6 deposit H3K27me1 over heterochromatin, which will suppress the DNA re-replication and transposon reactivation to maintain genome stability. Here, we found that atxr5 atxr6 displayed significantly fewer infected plants, milder symptoms, and lower viral …
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Investigation of The Roles of Asf1 and Caf-1-Mediated Chromatin Assembly In The Human Dna Damage Response
… kinases, enhancing its interaction with histones H3.1/H4 and CAF-1, and promoting the recruitment of MMS22L/TONSL to the damaged DNA to form the Rad51 nucleofilament during homologous recombination. We propose a model whereby DSB-induced phosphorylation of ASF1A promotes transient assembly of …
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Genome-Wide Localization And Novel Deposition Pathways Of Histone Variant H3.3 In Embryonic Stem And Neuronal Precursor Cells
… the first genome-wide profiles of histone H3 variants in pluripotent mammalian embryonic stem (ES) cells, and I establish the dependence and independence of these patterns on the histone chaperone Hira. To distinguish H3 variants, I use designed zinc finger nucleases (ZFNs) to rapidly knock …
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Bioorthogonal Chemical Reporters Reveal Fatty-Acylation of Histone H3 Variants and Cholesterol Modification of Proteins and Trafficking in Cells
… proteins were found, in particular histone H3 variants. Histones H3.1, H3.2 and H3.3 were demonstrated to be modified with fatty acid chemical reporters on the conserved cysteine 110, a novel site of S-acylation on histone H3.2. This newly discovered modification of histone H3 variants could …
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The structural analysis of histone H3 lysine 56 acetylation and related histone chaperone complexes
… Factor 1 (CAF-1) is responsible for depositing H3.1/H4 tetramers in a DNA synthesis dependent manner. During replication independent assembly H3.3/H4 is deposited by Histone Regulator (Hir) complex. In both instances nascent histone H3/H4 dimers are supplied by Anti-Silencing Factor 1 …
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The role of the histone variant H3.3 and its chaperones in the response to DNA damage
H3.3 is a histone variant without a clear, single function. Unlike the canonical replicationassociated H3.1 and H3.2, it is present throughout the cell cycle and can be deposited into chromatin by two distinct and specific chaperone complexes: ATRX/DAXX and HIRA. H3.3 and its chaperones have been …