Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 364 for “"H3+"”.
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Die Regulation der humanen H3-Histongene
… der 11 humanen replikationsabhängig-exprimierten H3-Histongene aufzuklären und Beziehungen zur in vivo-Expression der Gene zu untersuchen. Im ersten Teil der vorliegenden Arbeit wurde die in vivo-Expression der 11 H3-Histongene in drei humanen fötalen Geweben (Blase, Leber und Lunge) und acht …
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HISTAMINERGIC H3 AND CANNABINOID CB1 RECEPTORS IN DEMENTIA
… and potential therapeutic roles of Histaminergic H3 and Cannabinoid CB1 receptors in neurodegenerative diseases. Based on neurochemical investigations in postmortem human brain samples, the status of H3 receptors remain unchanged under vascular dementia or mixed dementia pathology, and may serve …
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Regulated Histone H3 Proteolysis During Mouse Embryonic Stem Cell Differentiation
… specifically focusing on those involving histone H3. First, in Chapter 2, I describe how certain non-histone chromatin proteins that are key to development specifically interact with modified histones using biochemical, biophysical and structural approaches. Next, in Chapter 3, I describe how …
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Variétés V2, V3, et variétés V4 à symétrie H2, H3
… H1, de l’hyperboloïde H2, et de l’hyperboloïde H3, on cherche les variétés pseudo-riemaniennes V4, munies de telles symétries."
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Die teenwoordigheid van histamien H3-reseptore op limfosiete en neutrofiele (Afrikaans)
No abstract available.
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Atomistic Investigation of Nucleosomal H3 Histone Tail in Unmodified and Epigenetically Modified States
… biological targets for cancer like the histone H3 tail motivated this work. Histone tails are integral structural and functional components of the eukaryotic nucleosome. These tails, rich in positively charged amino acid residues, interact with the DNA to stabilize the nucleosomal structure. …
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Histamine H3 Receptor Heterogeneity in the Central Nervous System in Aging and Dementia.
Abstract The histamine H3R is a classic G-protein coupled receptor and is a potential therapeutic target for a number of central nervous system pathologies. Major pharmacological heterogeneity between and within species has hindered the clinical development of H3R-targeted drugs. The …
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Characterisation of the (H3-H4)2-tetramer and its interaction with histone chaperones
… in the field: the structure of the soluble (H3-H4)2-tetramer, and the conformation of H3 and H4 in complex with histone chaperones.Firstly, we determined the conformation of histones H3 and H4 when in complex with two histone chaperones from S. cerevisaie, Nap1 and Vps75. Within the …
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Experimental study of the reaction He3 ([v], [pi+])H3 up to 260 MeV
… cross section for the, reaction He3(y,n+)H3 was measured for photon energies of 180 to/260 MeV (momentum transfer 1.2 F-1 to 1.9 F-1). A target of gaseous He at 20.4 K and approximately one atmosphere preesure was irradiated by a 270 MeV bremsstrahlung x-ray beam. The reaction was obserVed …
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Development and Characterization of B7-H3-Targeted Radioimmunotherapies For The Treatment of Solid Tumors
… Herein, we characterize novel<sup> </sup>anti-B7-H3 immuno-conjugates for PET imaging and RIT of solid tumors in preclinical models.</p> <p>Human B7-H3 (CD276) protein is highly expressed on solid tumor cell surfaces and endovascular surfaces in a wide variety of cancers (colon, breast, …
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Investigating a novel function of histone H3 in mitotic checkpoint control in Saccharomyces cerevisiae
Thesis (Ph. D.)--Michigan State University. Dept. of Biochemistry and Molecular Biology, 2010
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The structural analysis of histone H3 lysine 56 acetylation and related histone chaperone complexes
… Factor 1 (CAF-1) is responsible for depositing H3.1/H4 tetramers in a DNA synthesis dependent manner. During replication independent assembly H3.3/H4 is deposited by Histone Regulator (Hir) complex. In both instances nascent histone H3/H4 dimers are supplied by Anti-Silencing Factor 1 …
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Chemical physics and astrochemistry of H3+ and sub Doppler mid infrared spectroscopy of molecular ions
… intermediates in interstellar environments, and H3+ in particular is responsible for initiating a network of chemical reactions that ultimately results in the formation of the ~170 molecules detected so far in space. Yet fundamental questions about the interstellar abundances of the two nuclear …
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Differential cross sections for the reaction He4(gamma, p)H3 from 55 to 165 MeV
… have been measured for the reaction He4 (y,p)H3 for incident photons of 55 to 165 MeV. Outgoing protons and tritons from a low temperature He target were detected in coincidence at three angular settings in the 1aboratqry: (8p ' 8T) = (59.5, 106°), (88.5°, 75°), and (118°, 47.5°). The triton …
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Investigating the cosmic-ray ionization rate in the galactic interstellar medium through observations of H3+
Observations of H3+ in the Galactic diffuse interstellar medium (ISM) have led to various surprising results, including the conclusion that the cosmic-ray ionization rate (zeta_2) is about 1 order of magnitude larger than previously thought. The present survey expands the sample of diffuse cloud …
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Regulation of the Heterochromatin Protein 1 by Phosphorylation of Histone H3 and the HP1 Hinge Domain
… interaction with methylated lysine 9 of histone H3 (H3K9me). However, it has remained enigmatic how HP1 reversibly dissociates from chromatin during mitosis, while the histone mark that recruits the protein, H3K9me, persists. In the first part of my thesis, my collaborators and I show through a …
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JMJC Domain-Containing Histone Demethylase 2 (Jhd2): Bridging the Gap between H3K4 Trimethylation and H3 Acetylation
… a histone demethylase that functions to remove H3K4 methylation in S. cerevisiae. Jhd2 is a homologue of the human JARID1 family of histone demethylases, which has four members: JARID1A, B, C and D. JARID1B is of particular interest because it has been shown to be up regulated in 90 percent of …
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JMJC Domain-Containing Histone Demethylase 2 (Jhd2): Bridging the Gap between H3K4 Trimethylation and H3 Acetylation
… a histone demethylase that functions to remove H3K4 methylation in S. cerevisiae. Jhd2 is a homologue of the human JARID1 family of histone demethylases, which has four members: JARID1A, B, C and D. JARID1B is of particular interest because it has been shown to be up regulated in 90 percent of …
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