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Showing 1 to 4 of 4 for “"H2B ubiquitylation"”.
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The Role of Histone H2B Ubiquitylation and its Related Factors in Transcriptional Regulation in Mammalian Cells
… and recent studies in yeast also have implicated H2B ubiquitylation in the transcription of specific genes. However, a systematic study of H2B ubiquitylation in mammalian cells has been hindered by the lack of information about mammalian homologues of the yeast enzymes responsible for H2B …
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Sortase-mediated ubiquitylation of Histone H2B and its biological consequences
… of cell biological processes. Histone 2B (H2B) ubiquitylation has been suggested to collaborate in the complex mechanisms that control the activation or silencing of genes. Here we try to explain how we could use the sortagging technique to control ubiquitylation events inside the nuclear …
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Mechanistic Insights into Direct Interactions that Mediate the Activity of DOT1L Complex in MLL-Rearranged Leukemia
… that H3K79 methylation is dependent upon histone H2B ubiquitylation (H2Bub). However, there is a lack of understanding of how these interactions stimulate MLL-fusion target genes. Besides its catalytic activity, DOT1L complex activity has been postulated to regulate transcriptional elongation on …
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Mechanistic Insights into the Stimulation of Dot1L-Mediated Methylation of Histone H3 by Semisynthetically Ubiquitylated Histone H2b
… structure and function. One such modification, ubiquitylation of histone H2B on lysine 120 (uH2B), has been correlated with enhanced methylation of lysine 79 (K79) of histone H3 by K79-specific methyltransferase, disruptor of telomeric silencing-like (Dot1L/KMT4). However, the specific function …