Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"H2A.Z"”.
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Roles of H2A.z in Fission Yeast Chromatin
… Swr1 Complex which is known to exchange histone H2A variant H2A.z in nucleosomes. We purified H2A.z as a member of Swr1 Complex and its interaction with Swr1 Complex depends on Swr1. We’ve shown that histone H4 Lysine 20 trimethylation (H4 K20 Me3) is lost in h2A.z and msc1 deletion strains and …
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Functional analysis of the histone variant H2A.Z during lineage commitment
… In this thesis, we dissect the role of H2A.Z during lineage commitment. In particular, we focused on the Polycomb-mediated mono-ubiquitylation of H2A.Z. We found that this modification regulates the differentiation potential of mouse embryonic stem cells (mESCs). Loss of H2A.Z …
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H2A.Z : a molecular rheostat for gene regulation in embryonic stem cells
… development and differentiation. The histone H2A variant H2A.Z is highly conserved among eukaryotes and is of particular interest because it has an essential, yet unknown role in early development. H2A.Z is enriched at the promoter regions of most genes that harbor H3K4me3 in mouse embryonic …
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The Influence of DNA Methylation on Both H2A.Z Nucleosome Dynamics and the Zinc Finger and Homeoboxes Transcription Factor Family
… of chromatin proteins, the histone variant H2A.Z and the Zinc Finger and Homeoboxes (ZHX) family of transcription factors. DNA methylation and H2A.Z preferentially occupy exclusive areas of the genome, biasing against their colocalization in the same genomic space. However, exactly how this …
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Histone Variant H2A.Z Substitution Mediated by the SWR1-like Complex is a Novel Transcriptional Regulatory Mechanism Controlling Defense Genes and Immunity in Plants
… yeast homolog functions to exchange the histone H2A for its variant, H2A.Z. This replacement has been speculated to be involved in transcription regulation as it occurs in the promoter and/or genic region of actively transcribed genes. Interestingly, mutations in a few SWR1-like components led to …
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Étude du lien antagoniste existant entre la méthylation de l'ADN et le variant d'histoire H2A.Z : rôle du complexe TIP60/P400
… tumoral. De l’autre côté, le variant d’histone H2A.Z, qui permet de promouvoir la transcription des gènes, semble en mesure de protéger certains gènes de l’atténuation génique due à la méthylation de l’ADN. Dans la littérature, il a été démontré qu’il existait une relation antagoniste entre la …
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Analyzing the effects of Cis-elements and trans-factors on the stability of the Gal1 mRNP
… foci is chromatin-independent. Histone variant H2A.Z, likewise has been suggested to play a role in the post-transcriptional association of the yeast genes with the nuclear periphery. Our findings indicate that the loss of H2A.Z doesn’t alter gene-proximal mRNA retention, but has a differential …
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Regulation of Flo11p-dependent adhesion in <i>Saccharomyces cerevisiae</i>
… or remodeling identified the histone variant H2A.Z/Htz1p as yet unknown factor that is required to keep FLO11 in a silent state. The chromatin remodeler Rsc1p and the histone acetyl transferase Gcn5p are antagonists to H2A.Z/Htz1p and are required to overcome this silent state under glucose …
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MODES OF NUCLEOSOME INTERACTION AND MECHANISMS OF THE SACCHAROMYCES CEREVISIAE CHROMATIN REMODELERS INO80 AND ISW1A
… as catalyzes the exchange of histone variant H2A.Z for the canonical histone H2A, while SWR1 mediates the reverse exchange of H2A for H2A.Z, without being able to mobilize nucleosomes. We have found that INO80, in order to promote H2A-H2B dimer exchange, translocates along DNA at the H2A-H2B …
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Quiescence induces epigenetic changes in bovine fibroblasts and improves their reprogramming into cloned embryos
… abundance of RNA polymerase II, histone variant H2A.Z, as well as Polycomb group (PcG) proteins EED, SUZ12, PHC1 and RING2. Histone variant H3.3, PcG proteins EZH2 and histone deacetylase HDAC1 did not change compared to the G₁ controls. Following NT into metaphase-arrested oocytes, G₀ DNA …
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Structural and biochemical studies of the yeast linker histone, Hho1p
… in vitro. Hho1p and Htz1p, the yeast histone H2A.Z subtype, do not appear to interact directly in co-immunoprecipitation and chemical cross-linking assays, while chromatin immunoprecipitation studies show no evidence of colocalisation across the ADH2 and PHO5 genes. Hho1p and Sir2p cross-link …
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DYNAMICS OF NUCLEOSOME REMODELING BY ATP-DEPENDENT CHROMATIN REMODELERS
… centering and dimer exchange. INO80 exchanges H2A.Z-H2B dimer for H2A-H2B. We show that INO80 is incredibly slow at centering nucleosome compared to ISW2. We also provide evidence for a mechanism where INO80 persistently displaces DNA from the dimer interface, unlike ISW2, facilitating dimer …
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CHD Chromatin Remodelers Promote Epigenetic Control of Development in Arabidopsis thaliana
Chromatin remodeling is a vital biological process that facilitates activation and repression of gene expression as well as compaction of large eukaryotic genomes into compact nuclei. The CHD3 family of chromatin remodelers play key roles as epigenetic modifiers and transcriptional regulators in …