Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"H19"”.
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Oct4 and Sox2 regulate methylation at the Igf2/H19 imprinting control region
Mono-allelic expression of H19 and Igf2 depends on parental-specific methylation of an imprinting control region (ICR). Although CTCF sites maintain the absence of DNA methylation on maternal ICRs after fertilization, some Beckwith-Wiedemann patients showed maternal ICR methylation that correlated …
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The role of the Igf2/H19 locus in regulating murine placental endocrine capacity
… imprinted gene found in an imprinting locus with H19, a maternally expressed imprinted long noncoding RNA. In mice, manipulation of the expression of these genes or the differentially methylated imprinting control region (ICR1), which regulates their expression, leads to changes in fetoplacental …
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Molekulargenetische Analyse eines evolutionär konservierten Silencer-Elements aus dem murinen H19-Locus in Drosophila melanogaster
… Enhancer und Silencer zählen. Das murine H19-Gen ist einer der am intensivsten erforschten genomisch geprägten Loci. Eine zentrale Rolle in der monoallelischen Expression des H19-Gens spielt ein Silencer-Element, das die Repression des paternalen H19-Allels vermittelt. In transgenen …
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Imprinted Gene Expression and Phenotype of Bovine Concepti with Bos taurus and Bos indicus Genetics
… as their imprinted regulatory non-coding RNAs, H19 and AIRN, (ii) to analyse expression patterns of all identified transcripts in bovine pre- and postnatal tissues, and (iii) to investigate fetal genetic effects on gene expression and their association with heterotic phenotype. To this end, a …
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Tissue- specific DNA methylation profiles in newborns
… assess DNA methylation profiles of IGF2 DMR and H19 in DNA derived from four tissues of the newborn. We obtained from 6 newborns DNA from fetal placental tissue (n = 5), umbilical cord CD34+ hematopoietic stem cells (HSC) and CD34- mononuclear cells (MNC) (n = 6), and umbilical cord Wharton jelly …
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Establishment of a phenotypical model of adverse outcomes associated with assisted reproductive technologies
… on chromosome 11p15.5, namely the KvDMR1 and H19/IGF2. There is a similar overgrowth phenotype that is observed in ruminants as a result of embryo culture. This syndrome is known as large offspring syndrome (LOS). The genomic region/s associated with LOS have not yet been determined. We …
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Development and Application of Solid-State NMR Methods for Investigating Protein Structure and Dynamics
… orientation of water molecules above and below H19 and is associated with the charge state of H19.
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Evaluación de veinte híbridos de maíz (Zea mays L.) en cinco localidades de Nicaragua
… las localidades, superando al mejor testigo H19 (H-INTA 991) en 13 y 14 % respectivamente, no obstante, expresaron su mayor potencial en ambientes favorables. Los híbridos H11, H15 y H17 superaron en rendimiento a la media general y fueron identificados por AMMI como estables, por presentar …
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Epigenetic Response to Low-Dose Ionizing Radiation
… Second, three imprinted genes, Peg3, Nnat, and H19, were assessed for methylation changes in differentially methylated regions (DMRs) that regulate their parent-of-origin monoallelic expression using Sequenom technology. Lastly, it was postulated that the epigenetic changes at the Avy locus …
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Alterations in Genomic 5-Hydroxymethylcytosine Level in Hepatocellular Cancer
… analysis. Furthermore, specific regions of EGFR, H19, and 7SL loci also exhibited reduced 5-hmC levels in the tumor samples. Since aberrations in methylation can cause cancer including HCC, it would be important to identify differentially hydroxymethylated genes in the liver and the consequence of …
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AN ANALYSIS OF THE DIFFERENTIAL METHYLATION AND EXPRESSION OF IMPRINTED GENES IN M. M. MUSCULUS, M. M. DOMESTICUS, AND THEIR HYBRIDS
… parental samples. The genes I examined were <em>H19</em>, <em>Nap1l5</em>, <em>Igf2r</em>, <em>Mcts2</em>, and <em>Mest</em>. Differences in the expression levels of each of these genes were observed within the parental and hybrid samples.</p>
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Étude de l'influence de la température sur le fluage des conducteurs aériens de lignes de transport d'énergie électrique
… essais sur les brins, les fils d'aluminium 1350-H19 et d'almélec ont été testés en fluage pendant 1000 heures. Les fils ont été soumis à quatre niveaux de température d'opération : 20°C, 38°C, 55°C et 70°C et à quatre niveaux de contrainte : 15%, 25%, 35% et 47% RTA pour l'aluminium et 8%, 15%, …
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Lineage tracing of normal human development and childhood cancers
… represent an early clonal expansion driven by H19 hypermethylation. Lastly, using somatic mutations I discovered that the human placenta is made up of large clonal patches of closely related trophoblast cells. Comparing early embryonic mutations between placental lineages and umbilical cord …
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Paternal diet and exercise epigenetically program energy expenditure and glucose metabolism in mouse offspring
… such as: Ogt, Oga, Pdk4, Glut4, Ptpn1, Igf2, H19, and FoxO1. Furthermore, with the exception of Glut4, methylation patterns in fathers were preserved within male offspring. These novel findings suggest that offspring have a phenotype that is epigenetically programmed to thrive under the same …
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The epigenetics and role of Dopa Decarboxylase in heart development
… to be fundamental for imprinting of the Igf2/H19 locus through its binding to the germline differentially methylated region (gDMR). This thesis explores the occurrence of CTCF binding both genome-wide and at imprinting gDMRs in mouse brain in order to assess its relevance to the control of …
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The impact of mouse placental endocrine function on fetal resource allocation and adult offspring health
… we conditionally disrupted the imprinting of the H19-Igf2 locus in the mouse placental endocrine zone (junctional zone, Jz; maternally inherited Jz-ICR1). This is because this locus is important in controlling the formation and function of placental endocrine cells. Thus, the aims of this study …
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Impacts of low-water activity food type on inactivation kinetics and models of foodborne pathogens treated with low-temperature, vacuum-assisted steam processing
… stress. Thermal resistance of STEC strains (O121:H19 and O157:H7) were evaluated on the basis of strain variation, culture preparation, and water activity (D- and z-values). At the lowest treatment temperature (56°C), O121 displayed greater heat resistance than O157, and the broth-grown samples …
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Investigation of methods for reducing aflatoxin contamination in distillers grains
… converts the AFB1 to AFB2 and AFB 1-Citric (C23 H19 O13). Aflatoxin reduction was enhanced by adding more citric acid and prolonging the heating time.</p> <p>Performance of the HVACP system and generation of reactive species were characterized using optical emission spectroscopy and optical …