Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"H1299 Cells"”.
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The Effects of Tarsh Overexpression on Lung Carcinomas
Lung cancer arises from epithelial cells that line the air passages of the lungs. It is the second most common malignancy in the United States; trends suggest that over 228,000 new patients will be diagnosed with lung cancer in 2013. Due to the fact that lung cancer is highly aggressive, it has …
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UNDERSTANDING THE RELATIONSHIP BETWEEN ONCOLYTIC AD5 DELETED E1b55KDA LYTIC INFECTION AND P53 IN MAMMALIAN CELLS
… to selectivity replicate in and kill tumor cells. The p53 molecule is a tumor suppressor protein that responds to viral infection through the activation of apoptosis, which is inhibited by adenovirus E1B55kDa protein leading to progressive viral lytic cycle. The non-specificity of …
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Influence of genotoxic drug-induced post-translational modifications on mutant p53 stability and oncogenic activities
… to chemotherapy of the p53-null cell line H1299. We also found that mutant p53 phosphorylation does not affect subcellular localisation of mutant p53 and mutant p53-mediated inhibition of p63. Interestingly, ectopically expressed mutant p53 enhanced cell migration in H1299 cells. Notably, …
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Observing the effects of acetylcholinesterase and brain-derived neurotrophic factor on the levels of soluble amyloid precusor protein α in lung cancer cell media
… studies in our lab found that media from H1299 cells have lower levels of acetylcholinesterase (AChE) and intact amyloid-β40/42 (Aβ), and higher levels of mature brain-derived neurotrophic factor (mBDNF) when compared to A549 cell media. In conjunction to this the levels of soluble amyloid …
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Role of MDM2 In Cell Growth Regulation
… the G1-S phase transition in MDM2-arrested cells. MDM2 overexpression does not prevent expression of cyclin D, cyclin D-CDK mediated phosphorylation of Rb or cyclin E in normal, immortal or tumor-derived cells. However, MDM2 down-regulates cyclin A expression specifically in normal cells, …
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An investigation of mutant p53 function.
… of cell lines was established in the p53 null, H1299 lung cancer cell line, expressing wild-type or various p53 hotspot mutants under the control of an inducible promoter. These cell lines were harnessed to investigate a range of wildtype and mutant p53 functions. The induced wild-type p53 …
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STUDYING THE INTERACTION OF NANO- & MICROPLASTICS WITH ENTEROVIRUS AND THEIR CYTOTOXICITY ON HUMAN LUNG CELL LINE
Uncontrolled plastic waste degrades into micro- and nanoplastic particles that can be ingested by living organisms, including humans. These particles are of concern due to their ability to adsorb contaminants and their potential long-term cellular effects. This study investigated the interaction …